Cell cycle control

YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers. In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies.

18p vishanshan 27-06-2024 1 1   Download

A high expression pattern of minichromosome maintenance 2 (MCM2) has been observed in various cancers. MCM2 is a protein involved in the cell cycle and plays a role in cancer growth and differentiation by binding to six members of the MCM subfamily. The MCM protein family includes MCM2 through MCM7.

12p vishanshan 27-06-2024 1 1   Download

The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle control. Recent insights into how myocytes can be coaxed into duplicating in vivo might inform emerging therapeutics.

3p vibransone 28-03-2024 2 2   Download

Ebook "Natural compounds as inducers of cell death: Volume 1" gives a multi-disciplinary approach into the anti-cancer research field related to natural products and dietary compounds. Mainly, it covers the area of antitumor activity through an in-depth description of the cytotoxic, anti-inflammatory and anti-oxidant properties in cancer, inflammatory and cardio-vascular diseases.

512p manmanthanhla0201 26-02-2024 5 1   Download

Part 2 book "Molecular cell biology" includes content: Post transcriptional gene control and nuclear transport, signaling at the cell surface, signaling pathways that control gene activity, integration of signals and gene controls, moving proteins into membranes and organelles, vesicular traffic, secretion and endocytosis, metabolism and movement of lipids, microfilaments and intermediate filaments, microtubules, regulating the eukaryotic cell cycle, cell birth, lineage and death, cancer.

477p muasambanhan07 18-02-2024 5 1   Download

Ebook "Centromeres and kinetochores: Discovering the molecular mechanisms underlying chromosome inheritance" presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring.

552p lamquandat 28-12-2023 3 2   Download

Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our previous studies have suggested that tumor cell-derived connective tissue growth factor (CTGF) regulates the proliferation of MM cells as well as the tumor growth in mouse xenograft models.

12p vialfrednobel 23-12-2023 6 4   Download

Part 2 book "Molecular cell biology" includes content: Transmembrane transport of ions and small molecules; cellular energetics; moving proteins into membranes and organelles; vesicular traffic, secretion, and endocytosis; signal transduction and protein–coupled receptors; signaling pathways that control gene expression; cell organization and movement i: microfilaments; cell organization and movement II- microtubules and intermediate filaments; the eukaryotic cell cycle... and other contents.

448p oursky06 17-10-2023 3 1   Download

This study aimed to assess the effects of simulated microgravity (SMG) on senescent human fibroblasts (HFs). The HFs were treated with 150 µM H2O2 in a culture medium for 90 minutes for senescent induction. The senescent HFs were induced SMG for 72 hours by a Gravity simulator, while the control group was treated in the same CO2 incubator.

8p vicaptainmarvel 21-04-2023 5 2   Download

In a prospective randomized controlled trial, 70 patients undergoing elective thoracoscopic lobectomy were randomly allocated to the HPC group or the control group. Three cycles of 5-min hypoxia and 3-min ventilation applied to the nondependent lung served as the HPC intervention. Hypoxic preconditioning (HPC) may protect multiple organs from various injuries. We hypothesized that HPC would reduce lung injury in patients undergoing thoracoscopic lobectomy.

6p vizhangzhidong 29-12-2021 8 0   Download

Molecular targeted therapy for non-small cell lung carcinoma (NSCLC) is restricted due to resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). This study evaluated the efects of dual targeting of MEK and PI3K in human EGFR-TKI resistant NSCLC cell lines.

12p vimackenziebezos 29-11-2021 4 1   Download

Resistance to therapeutic agents and the highly toxic side effects of synthetic drugs has spurred new research in the treatment of colon cancer, which has high morbidity and mortality ratios. This study aims to clarify the molecular mechanisms of the anticarcinogenic properties of methanol extract of Viburnum opulus L. (EVO)and its main active compound, trans-p-coumaric acid (p-CA), on human colon cancer cells (DLD-1, HT-29, SW-620, Caco-2) and healthy colon epithelial cells (CCD-18Co).

12p thiencuuchu 27-11-2021 4 0   Download

This study aimed to estimate the effects of simulated microgravity (SMG) on mesenchymal stem cells (MSCs). The 3D clinostat was applied to induce to simulated microgravity on MSC. The results showed that the MSC density in control group was higher than the SMG group. The cell cycle analysis demonstrated that the MSC ratio in G0/G1 phase in SMG group was higher than that of the control group, while the MSC ratio in S phase and G2/M phase in SMG group was lower than those of the control group.

8p spiritedaway36 25-11-2021 10 0   Download

Flagella have been lost in the vegetative phase of the diatom life cycle, but they are still present in male gametes of centric species, thereby representing a hallmark of sexual reproduction. This process, besides maintaining and creating new genetic diversity, in diatoms is also fundamental to restore the maximum cell size following its reduction during vegetative division. Nevertheless, sexual reproduction has been demonstrated in a limited number of diatom species, while our understanding of its different phases and of their genetic control is scarce.

11p vilarryellison 29-10-2021 8 0   Download

Evolutionarily conserved RFX transcription factors (TFs) regulate their target genes through a DNA sequence motif called the X-box. Thereby they regulate cellular specialization and terminal differentiation. Here, we provide a comprehensive analysis of all the eight human RFX genes (RFX1–8), their spatial and temporal expression profiles, potential upstream regulators and target genes.

15p vibeauty 23-10-2021 10 0   Download

E2F/DP proteins have been shown to regulate genes implicated in cell cycle control and DNA repair. However, to date, research into the potential role of the Moso bamboo E2F/DP family has been limited.

15p vijichea2711 28-05-2021 7 1   Download

Forkhead transcription factors control cell growth in multiple cancer types. Foxd1 is essential for kidney development and mitochondrial metabolism, but its significance in renal cell carcinoma (ccRCC) has not been reported.

15p vianrose2711 27-04-2021 8 1   Download

The present study investigated how mouse fibroblasts changed under microgravity (SMG) conditions (< 10-3 G) simulated by 3D clinostat. Results showed that SMG condition markedly reduced the proliferation of mouse fibroblasts, significantly reducing the nuclear area and intensity. Compared to the control group, the mouse fibroblasts ratio of the SMG group was higher in the G0/G1 phase but lower in the S phase and G2/M phase...

6p nguaconbaynhay10 20-02-2021 6 2   Download

This chapter presents the following content: Most cell division results in genetically identical daughter cells, the mitotic phase alternates with interphase in the cell cycle, the eukaryotic cell cycle is regulated by a molecular control system.

51p tradaviahe14 27-01-2021 16 3   Download

In the male germ line of Drosophila chromatin remains decondensed and highly transcribed during meiotic prophase until it is rapidly compacted. A large proportion of the cell cycle-regulated histone H3.1 is replaced by H3.3, a histone variant encoded outside the histone repeat cluster and not subject to cell cycle controlled expression.

14p vimariana2711 22-12-2020 8 1   Download