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Cell surface receptors
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Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic regulator of low-density lipoprotein (LDL) by interacting with low-density lipoprotein receptor (LDLR). Recent studies have shown that PCSK9 can affect the occurrence and development of tumors and can be used as a novel therapeutic target. However, a comprehensive pan-cancer analysis of PCSK9 has yet to be conducted.
13p
vishanshan
27-06-2024
1
1
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This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin.
261p
vimeyers
29-05-2024
5
1
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Ebook "The neuropilins: Role and function in health and disease" covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases.
236p
ladongphongthanh1008
22-04-2024
8
4
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Ebook "TNF receptor associated factors (TRAFs)" is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection.
222p
ladongphongthanh1008
22-04-2024
1
1
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Ebook "Viral entry into host cells" for a virus to invade a host cell it needs to penetrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized surface proteins to meet this challenge. These proteins facilitate delivery of the viral genetic information into the host cell by either fusing the viral envelope with a host cell membrane or by forming membrane pores. Membrane fusion and pore formation critically depend on the engagement of host cell receptors and receptor choice is a key determinant of viral tropism.
213p
cotieubac1004
15-03-2024
0
0
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Ebook "Biochemical roles of eukaryotic cell surface macromolecules" covered include: neurochemical and biochemical analysis of cell surface glycoconjugates; membrane skeletal organization; GPCRs and other receptors; biophysical approaches to study membrane interactions; glycoconjugate metabolism; dysregulation; molecular mechanisms involved in cell-cell and cell-matrix interaction; glycans in infectious and neurological diseases; cancer and glycosyltransferases as drug targets.
408p
nhanphanguyet
28-01-2024
4
2
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Part 2 book "Veterinary immunology" includes content: How antigen binding receptors are made; t-cells and the destruction of cell associated invaders; innate lymphoid cells; regulation of adaptive immunity; the microbiota and the immune system; immunity at body surfaces; immunity in the fetus and newborn; vaccines and their production; the use of vaccines; immunity to bacteria and fungi; immunity to viruses; immunity to parasites,... and other contents.
576p
muasambanhan03
02-01-2024
5
2
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Coagulation and fibrinolysis are distinct processes that are highly correlated. Cells control coagulation and fibrinolysis by expression of tissue factor and urokinase-type plasminogen activator receptor on their surface.
12p
vialfrednobel
23-12-2023
4
3
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Fibronectin is an abundant and ubiquitous extracellular matrix component that regulates a wide range of cell functions by directly interacting with cell surface integrin receptors. In a prior study, we observed that fibronectin can accelerate the autologous cellular repopulation of implanted decellularized grafts, enhancing their adhesion capacity and biocompatibility, through fibronectin fibrillogenesis.
4p
viargus
20-02-2023
0
0
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One of the most popular ornamental plants worldwide, roses (Rosa sp.), are very susceptible to Botrytis gray mold disease. The necrotrophic infection of rose petals by B. cinerea causes the collapse and death of these tissues in both the growth and post-harvest stages, resulting in serious economic losses.
10p
vihagrid
30-01-2023
6
3
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Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for high-affinity antibodies and low-affinity ligands can be unambiguously identified when used in pools or as individual binding probes.
16p
vigalileogalilei
27-02-2022
16
1
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CD40 is an important tumor necrosis factor receptor (TNFR) family protein for the development of antitumor response against cancer cells, apart from its role in the regulation of the immune system as a costimulatory molecule. It is broadly expressed on the surface of immune cells and in diverse cancer types, including breast cancer. Here, we analyzed both CD40/CD40 ligand expression in breast cancer cells and tissues using public data sets and overall survival analysis in ungrouped breast cancer patients, as well as in the triple-negative breast cancer subtype.
9p
thiencuuchu
27-11-2021
13
1
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G-protein coupled receptors (GPCRs) are ancient, ubiquitous, constitute the largest family of transducing cell surface proteins, and are integral to cell communication via an array of ligands/neuropeptides.
20p
vigiselle2711
30-08-2021
10
1
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The behavior of cells in vivo is complex and highly dynamic, as it results from an interplay between intercellular matrix proteins with surface receptors and other microenvironmental cues.
15p
vilichoo2711
23-06-2021
7
1
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The most common cystic fibrosis (CF) manifestation is the progressive chronic obstructive pulmonary disease caused by deficiency, dysfunction, or absence of the CFTR (Cystic Fibrosis Transmembrane Regulator) protein on the apical surface of the cells in the respiratory tract.
9p
vianthony2711
16-04-2021
10
1
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Insulin and its plasma membrane receptor constitute an ancient response system critical to cell growth and differentiation. Studies using intact Rana pipiens oocytes have shown that insulin can act at receptors on the oocyte surface to initiate resumption of the first meiotic division.
17p
vimariana2711
22-12-2020
8
1
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Influenza virus spreads infection by two main surface glycoproteins, namely hemagglutinin (HA) and neuraminidase (NA). NA cleaves the sialic acid receptors eventually releasing newly formed virus particles which then invade new cells. Inhibition of NA could limit the replication of virus to one round which is insufficient to cause the disease.
11p
vioklahoma2711
19-11-2020
6
0
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Trogocytosis is defined as the transfer of cell-surface membrane proteins and membrane patches from one cell to another through contact. It is reported that human epidermal growth factor receptor 2 (HER2) could be transferred from cancer cells to monocytes via trogocytosis; however, the clinical significance of this is unknown.
12p
vialabama2711
21-09-2020
11
0
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Multidrug resistance (MDR) is a major obstacle to the treatment of gastric cancer (GC). Using a phage display approach, we previously obtained the peptide GMBP1, which specifically binds to the surface of MDR gastric cancer cells and is subsequently internalized. Furthermore, GMBP1 was shown to have the potential to reverse the MDR phenotype of gastric cancer cells, and GRP78 was identified as the receptor for this peptide
14p
vialabama2711
21-09-2020
18
0
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Emerging data have suggested that cell surface GRP78 is a multifunctional receptor and has been linked to proliferative and antiapoptotic signaling cascades. Activated α2−macroglobin (α2M*) is a natural circulating ligand of cell surface GRP78.
14p
vialabama2711
21-09-2020
13
2
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