Cell type specification

PANoptosis is a specific type of inflammatory programmed cell death (PCD) modality that can be involved in three key modes of cellular programmed cell death-pyroptosis, apoptosis and necroptosis.

13p vishanshan 27-06-2024 1 1   Download

Ebook "Handbook of industrial cell culture: Mammalian, microbial, and plant cells" attempts to link these common approaches, while also delineating those specific aspects of cell types, to give the reader not only an overview of the best current practices, but also of today’s evolving technologies, with examples of both their practical applications and their future potential.

548p dongmelo 27-05-2024 5 3   Download

Ebook "Adult stem cells (Second edition)" takes a critical look at issues concerning the developmental or differentiation potential for a variety of tissue types and for specific adult stem cell types. Since the first edition appeared a decade ago, our understanding of adult stem cells, and more specifically tissue-specific adult stem cells, has advanced tremendously. And an increased interest in regenerative medicine and potential stem cell applications has driven a quest for better understanding of stem cell biology.

433p ladongphongthanh1008 22-04-2024 2 1   Download

Ebook "Stem cells in modeling human genetic diseases" examples of the use of iPS cell technology, a recent Nobel Prize-winning scientific breakthrough, to obtain patient-specific pluripotent cells from which many types of specialized cells involved in a particular disease can be generated, including psychiatric and neurodegenerative disorders, muscular dystrophies, laminopathies, among others.

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Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored.

19p vibransone 28-03-2024 3 2   Download

The genetic and immunological factors that contribute to differences in susceptibility and progression between sub-types of inflammatory and autoimmune diseases continue to be elucidated. Inflammatory bowel disease and juvenile idiopathic arthritis are both clinically heterogeneous and known to be due in part to abnormal regulation of gene activity in diverse immune cell types.

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Only a small fraction of patients respond to the drug prescribed to treat their disease, which means that most are at risk of unnecessary exposure to side effects through ineffective drugs. This inter-individual variation in drug response is driven by differences in gene interactions caused by each patient’s genetic background, environmental exposures, and the proportions of specific cell types involved in disease.

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Measures of the adaptive immune response have prognostic and predictive associations in melanoma and other cancer types. Specifically, intratumoral T cell density and function have considerable prognostic and predictive value in skin cutaneous melanoma (SKCM).

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Patient stratification based on molecular subtypes is an important strategy for cancer precision medicine. Deriving clinically informative cancer molecular subtypes from transcriptomic data generated on whole tumor tissue samples is a non-trivial task, especially given the various non-cancer cellular elements intertwined with cancer cells in the tumor microenvironment.

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Expression quantitative trait loci (eQTL) databases represent a valuable resource to link diseaseassociated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under investigation.

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Preclinical studies require models that recapitulate the cellular diversity of human tumors and provide insight into the drug sensitivities of specific cellular populations. The ideal platform would enable rapid screening of cell type-specific drug sensitivities directly in patient tumor tissue and reveal strategies to overcome intratumoral heterogeneity.

15p vibransone 28-03-2024 3 2   Download

Genome-wide association studies (GWASs) have identified thousands of variants associated with asthma and other complex diseases. However, the functional effects of most of these variants are unknown. Moreover, GWASs do not provide context-specific information on cell types or environmental factors that affect specific disease risks and outcomes.

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Part 2 book "Chemical engineering of polymers - Production of functional and flexible materials" includes content: Study of temperature dependence of specific resistance of nickel tungsten coating on copper; topology of formation of latexes in heterogeneous static monomer water systems; synthesis and research of some phtalocyaninic dyes with Cu, Zn for testing in the systems of solar cells type; polymeric recording media based on carbazole containing copolymers and benzoxyphthalocyanines of transition metalsnment,... and other contents.

246p muasambanhan09 16-03-2024 1 1   Download

Efficient presentation of mutant peptide fragments by the human leukocyte antigen class I (HLA-I) genes is necessary for immune-mediated killing of cancer cells. According to recent reports, patient HLA-I genotypes can impact the efficacy of cancer immunotherapy, and the somatic loss of HLA-I heterozygosity has been established as a factor in immune evasion.

12p vicwell 29-02-2024 3 1   Download

The rapid advancement of single-cell transcriptomics in neurology has allowed for profiling of post-mortem human brain tissue across multiple diseases. Over the past 3 years, several studies have examined tissue from donors with and without diagnoses of Alzheimer’s disease, highlighting key changes in cell type composition and molecular signatures associated with pathology and, in some cases, cognitive decline.

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Biological processes are controlled by groups of genes acting in concert. Investigating gene–gene interactions within different cell types can help researchers understand the regulatory mechanisms behind human complex diseases, such as tumors.

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Ebook "The sticky synapse: Cell adhesion molecules and their role in synapse formation and maintenance" are responsible for the functional differences between the various types of neuronal synapses, have become one of the central themes of modern neurobiology. It is becoming increasingly clear that a misregulation of synaptogenesis and synaptic remodeling and dysfunctional neuronal synapses are at the heart of several human diseases, both neurological disorders and psychiatric conditions.

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In this study, new polyclonal antibodies detecting four TGM2 variants encoding protein from ENSEMBL database are produced and their specificities are confirmed by western blot analysis with E.coli overexpressing TGM2-002 protein, HEK293T cells overexpressing TGM2-S protein and human colon cancer samples.

11p vimarillynhewson 02-01-2024 6 2   Download

Part 2 book "Veterinary immunology" includes content: Immunity to bacteria and fungi, immunity to viruses, immunity to parasites, type I hypersensitivity, red cell antigens and type ii hypersensitivity, immune complexes and type III, hypersensitivity, type IV hypersensitivity; organ graft rejection; resistance to tumors; autoimmunity; organ specific autoimmune diseases; systemic immunological diseases; primary immunodeficiencies; secondary immunological defects; drugs and other agents that affect the immune system,...and other contents.

291p muasambanhan03 02-01-2024 5 2   Download

Ebook "Lipidomics of stem cells" combines the current knowledge on the role of lipids in stem cell pluripotency and differentiation. It showcases various approaches to the study of lipids and focuses on various types of stem cells and specific lipids driving maintenance or differentiation. The volume includes chapters reviewing roles of specific lipids in pluripotency, neurogenesis and exocytosis as well as in cancer stem cells.

217p lamquandat 28-12-2023 3 2   Download