Cellular energetics

Ebook "Metabolism in cancer" presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field.

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Part 1 book "Molecular cell biology" includes content: Life begins with cells, chemical foundations, protein structure and function, basic molecular genetic mechanisms, biomembranes and cell architecture, integrating cells into tissues, transport of ions and small molecules across cell membranes, cellular energetics, molecular genetic techniques and genomics, molecular structures of genes and chromosomes, transcriptional control of gene expression.

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Part 1 book "Farm animal metabolism and nutrition" includes content: Amino acid and peptide transport systems, measurement and significance of protein turnover, inter organ amino acid flux, phenethanolamine repartitioning agents, lipid metabolism, glucose availability and associated metabolism, aspects of cellular energetics, trace element dynamics, use of near infrared reflectance spectroscopy.

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Part 1 book "Heart failure - A companion to Braunwald's heart disease" includes content: Evolving concepts in the pathophysiology of heart failure, molecular basis for heart failure, cellular basis for heart failure, cellular basis for myocardial repair and regeneration, energetic basis for heart failure, molecular and cellular mechanisms for myocardial recovery,... and other contents.

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Part 2 book "Molecular cell biology" includes content: Transmembrane transport of ions and small molecules; cellular energetics; moving proteins into membranes and organelles; vesicular traffic, secretion, and endocytosis; signal transduction and protein–coupled receptors; signaling pathways that control gene expression; cell organization and movement i: microfilaments; cell organization and movement II- microtubules and intermediate filaments; the eukaryotic cell cycle... and other contents.

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Transporter proteins mediate the translocation of substances across the membranes of living cells. Many transport processes are energetically expensive and the cells use 20 to 60% of their energy to power the transportomes. We hypothesized that there may be an evolutionary selection pressure for lower energy transporters.

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Deregulation of cellular energetic metabolism was recently pointed out as a hallmark of cancer cells. This deregulation involves a metabolic reprogramming that leads to a high production of lactate. Lactate efflux, besides contributing for the glycolytic flux, also acts in the extracellular matrix, contributing for cancer malignancy, by, among other effects, induction of angiogenesis.

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(BQ) Part 1 of the document GENOSYS–exam preparatory manual for undergraduates biochemistry presents the following contents: Cell and subcellular organelles, enzymology, carbohydrates, proteins and amino acids, lipids, cellular energetics.

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Corynebacterium ammoniagenesis an overproducer of xanthosine-5¢-monophosphate (XMP) by consuming either glcose (glc) or glutamic acid (glu). Its energymetabolismwas studiedin vivousing 31 P NMR spectroscopy coupled with a circulating fermentation system (CFS). CFS enabled us to validate directly the cellular dependency on carbon sources and changes in biomolecules produced according to altera-tions in the cellular energetic status.

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NA helicases are ubiquitous molecular motor proteins which harness the chemical free energy of ATPhydrolysis to catalyze the unwinding of energetically stable duplex DNA, and thus play important roles in nearly all aspects of nucleic acid metabolism, including replication, repair, recombina-tion, and transcription. They break the hydrogen bonds between the duplex helix and move unidirectionally along the bound strand. All helicases are also translocases and DNA-dependentATPases.Most contain conserved helicase motifs that act as an engine to power DNA unwinding. ...

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DNA helicases are molecular
motor enzymes that use the energy of NTP hydrolysis to separate transiently energetic-ally stable duplex DNA into single strands. They are there-fore essential in nearly all DNA metabolic transactions. They act as essential molecular tools for the cellular machinery. Since the discovery of the first DNA helicase in Escherichia coliin1976, several havebeen isolated fromboth prokaryotic and eukaryotic systems.

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