Cellular processes

Clear cell renal cell carcinoma (ccRCC) is the prevailing histological subtype of renal cell carcinoma and has unique metabolic reprogramming during its occurrence and development. Cell senescence is one of the newly identified tumor characteristics. However, there is a dearth of methodical and all-encompassing investigations regarding the correlation between the broad-ranging alterations in metabolic processes associated with aging and ccRCC.

23p vishanshan 27-06-2024 2 1   Download

Most cancer patients ultimately die from the consequences of distant metastases. As metastasis formation consumes energy mitochondria play an important role during this process as they are the most important cellular organelle to synthesise the energy rich substrate ATP, which provides the necessary energy to enable distant metastasis formation.

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The primary aim of Cerebral Signal Transduction: From First to Fourth Messengers, therefore, is to offer a comprehensive picture of the recent advances made in the signaling field as it relates to neuronal and cere­ bral function. The current state of progress provides an exciting opportunity for such a comprehensive focus because molecular tools have become available to selectively remove, reduce, or enhance spe­ cific components in the signaling pathways, e. g. , by interfering with the genes encoding key proteins.

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This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin.

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Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor.

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In ebook "Biohybrid systems: Nerves, interfaces, and machines" the discipline of neurodesign is a highly interdisciplinary one, while at the same time in the process of maturing towards real-life applications. The breakthrough about to be achieved is to close the loop in communication between neural systems and electronic and mechatronic systems and actually let the nervous system adapt to the feedback from the man-made systems. To master this loop, scientists need a sound understanding of neurology, from the cellular to the systems scale, of man-made systems and how to connect the two.

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Ebook "Dyneins: Structure, biology and disease" offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. Broad-based up-to-date resource for the dynein class of molecular motors.

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Ebook "Growth of farm animals (Second edition)" continues to fill the important role of helping readers to understand how the basics of growth must be thoroughly understood if farm animals are to be used efficiently and humanely in producing food for mankind. Showing the progression from cell to tissue to entire animal, this comprehensive textbook provides an essential broad base for animal production, with key information on how animals grow and change in shape and composition, and factors that affect these processes.

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Part 2 book "Automotive engineering - Lightweight, functional, and novel materials" includes content: Formability of aluminum alloys, ductile magnesium, enhancement of crashworthiness in cellular structures, compressive properties of cellular metals, heavily deformable al alloy, stainless steel sandwich sheets with fibrous metals cores, welding and joining, titanium aluminide based intermetallic alloys, casting processes and simulation tools, damage tolerance in composite structures, high performance autosport surface treatments and composites.

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This study summarizes a sample of the managers of the Iraqi cellular communications company with 84 employees. The company is a service organization responsible for providing integrated telecommunications services. As a management system that uses human, technical, material and financial resources, its size and value increase in line with technical progress. The demand for telecommunication services is increasing for several factors, the most important being the only means available to the majority and to the increase in population.

6p longtimenosee10 26-04-2024 1 1   Download

Ebook "RNA interference from biology to therapeutics" addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers.

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Ebook "Stem cells & regenerative medicine: From molecular embryology to tissue engineering" is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications.

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Ebook "Systems biology of apoptosis" summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches.

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Ebook "Mitochondria and cell death" examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity.

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Ebook "CFTR and cystic fibrosis: From structure to function" is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular processes involved in this conformational disorder. Starting with a historical perspective on cystic fibrosis and its clinical features, the author departs into an in-depth description of the biology of the CFTR protein, ending with a discussion on the latest approaches aimed at developing corrective therapies for cystic fibrosis.

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High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult, preclude histopathological triage of samples, and limit the ability to perform batch processing.

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In ebook "Pore structure in food: Simulation, measurement and applications" the pore structure of foods directly affects the success of such food processes as drying, puffing, freeze-drying, and rehydration. Consequently, the pore structure of foods determines what types of food processes will work best with a particular food. This Brief will first discuss in depth the need to correctly measure the pore structure of foods and then will identify and describe in detail the current methods available to measure food porosity. Finally, it will review the applications of these various methods. ​

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Ebook "SUMO regulation of cellular processes (Second edition)" of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins.

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Ebook "Actin-monomer-bindingproteins (Molecular biology intelligence unit series)" summarizes the current knowledge on actin dynamics and presents examples of how actin monomer binding proteins regulate actin filament assembly and contribute to various cellular processes. It is important to note that many actin monomer binding proteins also display other activities besides interaction with unpolymerized actin.

127p duongthandue0501 28-02-2024 5 1   Download

Ebook "Zinc signals in cellular functions and disorders" describes the crucial role of "zinc signals" in biological processes on a molecular and physiological basis, discussing future directions and questions underlying this unique phenomenon. To accomplish this, a group of worldwide leaders in the field, who have made outstanding contributions, overview zinc signals from a professional standpoint.

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