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Childhood leukemia
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Central nervous system (CNS) tumors are the most common solid tumors in children and the leading cause of cancer-related death in the latter. Currently, the incidence rate exceeds that of leukemia and ranks first in the incidence of malignant tumors in children.
10p
vikoch
27-06-2024
1
1
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In children, the central nervous system tumors are exceeded in incidence only by leukemia and are more common than any of the other malignancies of childhood. Childhood central nervous system tumors encompass a range of histologic varieties from the histologically benignappearing pilocytic astrocytoma to the extremely malignant-appearing glioblastoma multiforme and the undifferentiated primitive neuroectodermal tumors. Similarly, the biologic behavior of childhood brain tumors varies not only according to histology but also with location of the tumor and age.
518p
vimeyers
29-05-2024
2
2
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Tight regulatory loops orchestrate commitment to B cell fate within bone marrow. Genetic lesions in this gene regulatory network underlie the emergence of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The initial genetic hits, including the common translocation that fuses ETV6 and RUNX1 genes, lead to arrested cell differentiation.
25p
vibransone
28-03-2024
6
1
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Umbilical cord blood transplantation (UCBT) from unrelated donors is one of the successful treatments for acute leukemia in childhood. The most frequent side effect of UCBT is peri-engraftment syndrome (PES), which is directly associated with the greater prevalence of acute and chronic graft-versus-host-disease (aGvHD and cGvHD).
11p
vileonardodavinci
23-12-2023
4
2
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Many cytogenetic changes and gene mutations are associated with acute myeloid leukemia (AML) survival outcomes. CD56 is related to poor prognosis when expressed in adult AML patients. However, the prognostic value of CD56 in children with AML has rarely been reported. In this research, we aimed to evaluate the prognostic value of CD56 in childhood AML.
9p
vileonardodavinci
23-12-2023
5
2
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Part 1 book "The molecular basis of cancer" includes content: Molecular biology of childhood neoplasms, biology of adult myelocytic leukemia and myelodysplasia, biology of adult myelocytic leukemia and myelodysplasia, molecular mechanisms of esophageal cancer, molecular basis of lung cancer, colon and rectal cancer, molecular pathogenesis of pancreatic adenocarcinoma.
536p
oursky01
24-07-2023
3
2
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Down’s syndrome is the most common chromosomal abnormality in humans. It has been associated with central nervous system tumors such as primary acute lymphoblastic leukemia and germinomas, but desmoplastic infantile astrocytoma has not yet been reported with Down’s syndrome.
9p
vigamora
23-05-2023
5
2
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High-dose methotrexate (HD-MTX) is used in the treatment of different childhood cancers, including leukemia, the most common cancer type and is commonly defined as an intravenous dose of at least 1 g/m2 body surface area per application. A systematic review on late effects on different organs due to HD-MTX is lacking.
12p
vipriyankagandhi
27-07-2022
4
1
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This study was aimed to evaluate the value of DNA index (DI) among pediatric acute lymphoblastic leukemia (ALL) treated on Children’s Oncology Group (COG) protocols between 2000 and 2015.
10p
vimahuateng
26-11-2021
7
1
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The prognosis of childhood acute lymphoblastic leukemia (ALL) is optimistic with a 5-year event-free survival (EFS) rate of 70–85%. However, the major causes of mortality are chemotherapy toxicity, infection and relapse.
11p
vianrose2711
27-04-2021
4
0
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Acute lymphoblastic leukemia (ALL) represent about 77% of leukemia in children and it is one of the most common malignancies in children. Bone Sialoprotein-1 is a tumor – associated antigen that is highly expressed in many malignancies in human. This study was aimed to study the role of Bone Sialoprotein-1 and its receptors CD44 variant 6 in children’s with acute lymphoblastic Leukemia in Tanta University Hospital. This study was carried out in hematology unit, pediatric department and clinical pathology department, Tanta university hospital, Egypt.
8p
angicungduoc8
07-11-2020
21
2
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The MRE11, RAD50, and NBN genes encode proteins of the MRE11-RAD50-NBN (MRN) complex involved in cellular response to DNA damage and the maintenance of genome stability. In our previous study we showed that the germline p.I171V mutation in NBN may be considered as a risk factor in the development of childhood acute lymphoblastic leukemia (ALL) and some specific haplotypes of that gene may be associated with childhood leukemia.
8p
vijennie2711
29-09-2020
15
2
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Mercaptopurine (6-MP) plays a pivotal role in treatment of childhood acute lymphoblastic leukemia (ALL); however, interindividual variability in toxicity of this drug due to genetic polymorphism in 6-MP metabolizing enzymes has been described.
5p
virose2711
24-09-2020
22
1
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Acute leukemia in early age (EAL) is characterized by acquired genetic alterations such as MLL rearrangements (MLL-r). The aim of this case-controlled study was to investigate whether single nucleotide polymorphisms (SNPs) of IKZF1, ARID5B, and CEBPE could be related to the onset of EAL cases (
7p
virose2711
25-09-2020
14
1
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Previous studies have indicated that survivors of childhood acute lymphoblastic leukemia (ALL) have an increased morbidity measured in terms of health care utilization. However, earlier studies have several potentially important limitations.
9p
virose2711
22-09-2020
13
2
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A select number of relatively rare metastatic malignancies comprising trophoblast tumours, the rare childhood cancers, germ cells tumours, leukemias and lymphomas have been routinely curable with chemotherapy for more than 30 years. However for the more common metastatic malignancies chemotherapy treatment frequently brings clinical benefits but cure is not expected.
25p
vialabama2711
21-09-2020
10
1
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B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading causes of childhood cancer-related mortality. Its most common chromosomal aberration is the ETV6-RUNX1 fusion gene, with ~25 % of ETV6-RUNX1 patients also carrying PAX5 alterations.
6p
viamsterdam
18-09-2020
14
1
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The identification of oncogenic driver mutations has largely relied on the assumption that genes that exhibit more mutations than expected by chance are more likely to play an active role in tumorigenesis. Major cancer sequencing initiatives have therefore focused on recurrent mutations that are more likely to be drivers.
8p
viamsterdam
18-09-2020
10
1
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Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. While the multi-step model of pediatric leukemogenesis suggests interplay between constitutional and somatic genomes, the role of inherited genetic variability remains largely undescribed. Nonsyndromic familial ALL, although extremely rare, provides the ideal setting to study inherited contributions to ALL.
9p
viamsterdam
18-09-2020
11
1
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Acute lymphocytic leukemia (ALL) is the most common pediatric cancer. The exact cause is not known in most cases, but past epidemiological research has suggested a number of potential risk factors. This study evaluated associations between environmental and parental factors and the risk for ALL in Egyptian children to gain insight into risk factors in this developing country.
7p
vimale2711
25-08-2020
13
1
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