Chiral specificities

Esterases are often overexpressed in cancer cells and can have chiral specificities different from that of the corresponding normal tissues. For this reason, ester prodrugs could be a promising approach in chemotherapy.

14p virose2711 25-09-2020 9 1   Download

Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodrug esters. Prodrug esters are inactive compounds that can be preferentially activated by esterase enzymes.

13p vilisa271 22-09-2020 8 1   Download

This concentration of industrial activity has stimulated a substantial economic boom in Jepara and surrounding areas and attracted local political support. For example, the need for container trucks to export furniture led the previous Bupati (district administrator) to have some major roads in the district reclassified as ‘provincial class’ roads. This allowed container trucks to reach most parts of the district, stimulating economic growth by attracting more people and activities, generating new trade and industry, and elevating economic activity around Jepara to a new level.

30p can_thai 10-12-2012 56 2   Download

Contracting authorities will have to indicate in the contract notice and tender documents how many additional points will be awarded for each award criterion. Environmental award criteria should, altogether, account for at least 10 to 15 % of the total points available. Where the award criterion is formulated in terms of “better performance as compared to the minimum requirements included in the technical specifications”, points will be awarded in proportion to the improved performance. ...

24p connhobinh 10-12-2012 31 2   Download