Chromosome elimination

The CRISPR/Cas9 system has become an efficient gene editing method for generating cells carrying precise gene mutations, including the rearrangement and deletion of chromosomal segments. However, whether an entire chromosome could be eliminated by this technology is still unknown.

18p vialfrednobel 29-01-2022 14 0   Download

The lower Dipteran fungus fly, Sciara coprophila, has many unique biological features that challenge the rule of genome DNA constancy. For example, Sciara undergoes paternal chromosome elimination and maternal X chromosome nondisjunction during spermatogenesis, paternal X elimination during embryogenesis, intrachromosomal DNA amplification of DNA puff loci during larval development, and germline-limited chromosome elimination from all somatic cells.

23p vitzuyu2711 29-09-2021 12 1   Download

Artificial synthesis of octoploid rapeseed double haploid (DH) induction lines Y3380 and Y3560 was made possible by interspecific hybridization and genome doubling techniques. Production of pure lines by DH induction provides a new way to achieve homozygosity earlier in B.napus.

13p vijichea2711 28-05-2021 19 1   Download

The possibility of obtaining dihaploid durum wheat (Triticum durum L.) plants by interspecific hybridization with Imperata cylindrica L. was studied. Ten local varieties and 1 commercial durum wheat variety (Triticum durum L., 2n = 4x = 28; AABB) were used as maternal lines.

7p danhdanh11 11-01-2019 21 1   Download

Alterations in chromatin packing are not the only physical manifestations of cancer. A cluster of tumour cells will also usually display gross structural changes that pathologists use for diagnosis: cells look visibly deformed and are often enlarged, with swollen and misshapen nuclei; and the chromosomes are distri- buted eccentrically. In an attempt to study these chan- ges more accurately, researchers at ASU’s Biodesign Institute have developed an optical computerized tomography (CT) scan for individual cells.

7p taisaokhongthedung 09-01-2013 38 4   Download

Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I. As such, HR is indispensable for the maintenance of genome integrity and the avoidance of cancers in humans. The HR reaction is mediated by a conserved class of enzymes termed recombinases.

32p taytrang001 25-12-2012 71 7   Download