Chromosome replication

Part 1 book "Essential cell biology" includes content: Cells - The fundamental units of life, chemical components of cells energy, catalysis and biosynthesis, protein structure and function, DNA and chromosomes, DNA replication and repair, from DNA to protein - How cells read the genome, control of gene expression, how genes and genomes evolve, analyzing the structure and function of genes.

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Ebook "DNA replication: From old principles to new discoveries" eviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field.

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Ebook "Genome instability: Methods and protocols" presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches.

654p lucchinguyen 28-12-2023 5 2   Download

Part 1 book "Alberts - Essential cell biology" includes content: Cells - the fundamental units of life; chemical components of cells; energy, catalysis, and biosynthesis; protein structure and function; DNA and chromosomes; DNA replication, repair, and recombination; from DNA to protein - how cells read the genome; control of gene expression; how genes and genomes evolve; modern recombinant DNA technology.

383p muasambanhan01 13-12-2023 4 2   Download

Part 1 book "Molecular biology of the cell" includes content: Cells and genomes; cell chemistry and bioenergetics; proteins DNA, chromosomes, and genomes; DNA, replication, repair, and recombination; how cells read the genome - from DNA to protein; control of gene expression; analyzing cells, molecules, and systems; visualizing cells.

599p oursky02 06-08-2023 4 2   Download

The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract the shortening of telomere repeats during replication for their unlimited proliferation by reactivating the reverse transcriptase telomerase or by using the alternative lengthening of telomeres (ALT) pathway.

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Vacuolar protein sorting-associated protein 4B (VPS4B) is a member of the ATP enzyme AAA protein family, and is mainly involved in protein degradation and cell membrane fusion. Recently, a dominant mutation in this gene was identified in human dentin dysplasia type I (DD-I).

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POLG, located on nuclear chromosome 15, encodes the DNA polymerase γ(Pol γ). Pol γ is responsible for the replication and repair of mitochondrial DNA (mtDNA). Pol γ is the only DNA polymerase found in mitochondria for most animal cells. Mutations in POLG are the most common single-gene cause of diseases of mitochondria and have been mapped over the coding region of the POLG ORF.

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Capture Hi-C (CHi-C) is a new technique for assessing genome organization based on chromosome conformation capture coupled to oligonucleotide capture of regions of interest, such as gene promoters. Chromatin loop detection is challenging because existing Hi-C/4C-like tools, which make different assumptions about the technical biases presented, are often unsuitable.

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To facilitate indefinite proliferation, stem cells and most cancer cells require the activity of telomerase, which counteracts the successive shortening of telomeres caused by incomplete DNA replication at the very end of each chromosome.

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Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in germ line cells it causes a condition called inherited chromosomally integrated HHV-6 (iciHHV-6). Only two complete genomes are available for replicating HHV-6B, leading to numerous conflicting annotations and little known about the global genomic diversity of this ubiquitous virus.

17p vibeauty 23-10-2021 5 1   Download

The development of chromosomal conformation capture techniques, particularly, the Hi-C technique, has made the analysis and study of the spatial conformation of a genome an important topic in bioinformatics and computational biology. Aided by high-throughput next generation sequencing techniques, the Hi-C technique can generate genome-wide, large-scale intra- and inter-chromosomal interaction data capable of describing in details the spatial interactions within a genome.

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Aneuploidy, or abnormal chromosome numbers, severely alters cell physiology and is widespread in cancers and other pathologies. Using model cell lines engineered to carry one or more extra chromosomes, it has been demonstrated that aneuploidy per se impairs proliferation, leads to proteotoxic as well as replication stress and triggers conserved transcriptome and proteome changes.

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DNA replication in trypanosomatids operates in a uniquely challenging environment, since most of their genomes are constitutively transcribed. Trypanosoma cruzi, the etiological agent of Chagas disease, presents high variability in both chromosomes size and copy number among strains, though the underlying mechanisms are unknown.

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The genome of Vibrionaceae bacteria, which consists of two circular chromosomes, is replicated in a highly ordered fashion. In fast-growing bacteria, multifork replication results in higher gene copy numbers and increased expression of genes located close to the origin of replication of Chr 1 (ori1).

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Molecular interactions between proteins and DNA molecules underlie many cellular processes, including transcriptional regulation, chromosome replication, and nucleosome positioning. Computational analyses of protein-DNA interactions rely on experimental data characterizing known protein-DNA interactions structurally and biochemically.

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Antibiotic resistance and the particular emergence of multi - resistant bacterial strains are clinically relevant issue involving serious threats to public health worldwide. DNA methylation, which changes the affinity and interaction of regulatory proteins with DNA, is an epigenetic mechanism that regulates numerous bacterial physiological processes, including chromosome replication, DNA segregation, mismatch repair, transposition and transcription.

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Different from the linear chromosomes of eukaryotes, most chromosomes of bacteria are circular. In this paper, we investigated the arrangement of trimers in Bacillus cereus chromosome by recording physical positions of individual trimers along the single-stranded sequence of this chromosome in the 5’ to 3’ direction. Our very first finding was that numbers of individual trimers in this chromosome were very much not the same. In an attempt to find out how the trimers were arranged along the chromosome, we found that every trimer was distributed unevenly and throughout the chromosome.

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(bq) part 1 book "biology" has contents: the chemical basis of life, general features of cells; membrane structure, synthesis, and transport; photosynthesis; cell communication; multicellularity; nucleic acid structure, dna replication, and chromosome structure; gene expression at the molecular level,... and other contents.

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(BQ) Part 1 of the document High-Yield cell and molecular biology - Cell and molecular biology presents the following contents: Chromosomal DNA, chromosome replication, meiosis and genetic recombination, the human nuclear genome, the human mitochondrial genome, protein synthesis, control of gene expression, mutations of the dna sequence.

75p thangnamvoiva3 28-06-2016 44 5   Download