Chronic myelogenous leukemia

Abelson (ABL) tyrosine kinase inhibitors (TKIs) are effective against chronic myeloid leukemia (CML); however, many patients develop resistance during ABL TKI therapy. Vitamin K2 (VK2) is a crucial fat-soluble vitamin used to activate hepatic coagulation factors and treat osteoporosis.

11p vioracle 29-09-2023 4 2   Download

Synchronous or metachronous multiple primary malignancies (MPMs) are a known phenomenon. These occurrences may be spontaneous or related to environmental risk factors or genetic predisposition. Chronic myelogenous leukemia (CML) and Multiple myeloma (MM) are two uncommon hematologic malignancies, arises from two different cell lineage.

6p videadpool 05-05-2023 4 2   Download

Leukemic cells facilitate the creation of the tumor-favorable microenvironment in the bone marrow niche using their secreted factors. There are not comprehensive details about immunosuppressive properties of chronic myelogenous leukemia-derived exosomes in the bone marrow stromal and immune compartment.

11p vimahuateng 26-11-2021 6 0   Download

Atypical Myeloproliferative Neoplasms (aMPN) share characteristics of MPN and Myelodysplastic Syndromes. Although abnormalities in cytokine signaling are common in MPN, the pathophysiology of atypical MPN still remains elusive.

11p vimanila2711 25-06-2020 11 1   Download

The mechanism of EphB4/ephrinB2 in the resistance of chronic myelogenous leukemia to imatinib keeps unknown. The imatinib resistant chronic myelogenous leukemia cell line-K562-R, was established. EphB4 receptor expression was detected in patients and resistant cells. Cell migration and drug sensitivity were tested in the EphB4 knockdown cells and mouse models.

9p viwashington2711 04-12-2019 9 1   Download

part 1 book “handbook of hematologic malignancies” has contents: hematopathology diagnostic techniques and assays, polycythemia vera, essential thrombocythemia, primary myelofibrosis, chronic myelogenous leukemia, chronic neutrophilic leukemia, systemic mastocytosis,… and other contents.

176p tieu_vu14 15-08-2018 27 1   Download

Bài giảng Những rối loạn tăng sinh tủy (Myeloproliferative neoplasms) trình bày những nội dung chính như: Bạch cầu mạn dòng tủy (chronic myelogenous leukemia: CML), đa hồng cầu nguyên phát (Polycythemia vera: PV), tăng tiểu cầu nguyên phát (Essential thrombocythemia: ET), tăng tiểu cầu nguyên phát (Essential thrombocythemia: ET). Mời các bạn cùng tham khảo.

57p tangtuy04 23-03-2016 99 9   Download

Learners enrolled in all healthcare training programs need to have a basic understanding of medical genetics so that they can successfully transition from students to clinicians. The field of medical genetics is advancing at a fast pace and is becoming increasingly integral to all aspects of medicine. This fact emphasizes the need for every practicing clinician and faculty member to develop an in-depth knowledge of the principles of human genetics, given that they are applicable to such a wide variety of clinical presentations.

249p bachduong1311 07-12-2012 62 6   Download

The preparation of human karyotype for the first time in 1959 led to the identification of numerical aberrations in the following years associated with Down’s, Turner and Klinefelter syndromes which implied the need for routine screening for chromosomal anomalies in certain clinical conditions.

512p conquynho32 15-09-2012 62 8   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Improvement of platelet dysfunction in chronic myelogenous leukemia following treatment with imatinib: a case report...

4p thulanh25 07-12-2011 31 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Gender and ethnic differences in chronic myelogenous leukemia prognosis and treatment response: a single-institution retrospective study

8p toshiba24 06-12-2011 42 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Activation of the hedgehog pathway in chronic myelogeneous leukemia patients

5p toshiba22 21-11-2011 53 2   Download

Chronic Myelogenous Leukemia: Treatment The therapy of CML is changing rapidly because we have a proven curative treatment (allogeneic transplantation) that has significant toxicity and a new targeted treatment (imatinib) with excellent outcome based on 5-year follow-up data. Therefore, physician experience and patient preference must be factored into the treatment selection process. Discussion of both treatment options with a patient is indicated. The decision should focus on the outcomes, risks, and toxicities of the various approaches.

5p thanhongan 07-12-2010 72 3   Download

Chronic Myelogenous Leukemia Incidence The incidence of chronic myelogenous leukemia (CML) is 1.5 per 100,000 people per year, and the age-adjusted incidence is higher in men than in women (2.0 versus 1.2). The incidence of CML increases slowly with age until the middle forties, when it starts to rise rapidly. CML incidence for males decreased slightly (4.4%) between 1997 and 2003 as compared to 1977–1997. Definition The diagnosis of CML is established by identifying a clonal expansion of a hematopoietic stem cell possessing a reciprocal translocation between chromosomes 9 and 22.

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Table 79-3 Representative Oncogenes at Chromosomal Translocations Gene (Chromosome) Translocation Malignancy ABL BCR (22q11) (9q34.1)– (9;22)(q34;q11) Chronic myelogenous leukemia ATF1 EWS (22q12) (12q13)– (12;22)(q13;q12) Malignant melanoma of soft parts (MMSP) BCL1 IgH (14q32) (11q13.3)– (11;14)(q13;q32) Mantle lymphoma cell BCL2 IgH (14q32) (18q21.

5p konheokonmummim 03-12-2010 66 3   Download

The differential diagnostic possibilities are much fewer when the spleen is "massively enlarged," palpable more than 8 cm below the left costal margin or its drained weight is ≥1000 g (Table 60-3). The vast majority of such patients will have non-Hodgkin's lymphoma, chronic lymphocytic leukemia, hairy cell leukemia, chronic myelogenous leukemia, myelofibrosis with myeloid metaplasia, or polycythemia vera.

5p konheokonmummim 03-12-2010 76 3   Download