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Chronic viral hepatitis
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Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases. The confinement of HBV replication to the liver, which also acts as the central hub for metabolic and nutritional regulation, emphasizes the interlinked nature of host metabolism and the disease.
13p
vioraclene
31-03-2024
6
2
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Hepatocellular carcinoma (HCC) is a primary tumor of the liver. The majority of HCCs are associated most frequently with chronic B or C viral hepatitis, alcohol intake or aflatoxin exposure. Cirrhosis is a strong risk factor associated with HCC.
8p
vitiki
30-01-2024
9
2
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Introduction: Mother-to-child transmission is a major route of hepatitis B virus (HBV) transmission, particularly in highly endemic areas. The aim of our work was to determine the extent of HBV serological markers in pregnant women in the Mifi district (West Cameroon).
5p
viwolverine
07-07-2023
2
1
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The results obtained in this work demonstrate a high prevalence of CHB/OBI in the region and indicate the need for further large-scale studies of HBV in order to improve strategies for disease control and prevention in the Vietnam.
8p
vineville
08-02-2023
4
1
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Interferon-stimulated gene 20 (ISG20) plays an important role in viral infection and cancers. This study investigated the association between ISG20 rs4566136 polymorphism with HBV-related hepatocellular carcinoma.
10p
viangelamerkel
18-07-2022
4
2
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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in Africa. In Africa, the major causes of HCC include chronic infection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV). Knowledge of the changes in the incidence of viral hepatitis-associated HCC over time and the factors responsible for such changes is key in informing policies for the prevention of viral hepatitis-associated HCC in Africa.
13p
vimahuateng
26-11-2021
8
0
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Viral populations are complex, dynamic, and fast evolving. The evolution of groups of closely related viruses in a competitive environment is termed quasispecies. To fully understand the role that quasispecies play in viral evolution, characterizing the trajectories of viral genotypes in an evolving population is the key. In particular, longrange haplotype information for thousands of individual viruses is critical; yet generating this information is non-trivial.
12p
vilarryellison
29-10-2021
13
1
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To assess the association between serum HBsAg level, hepatitis B virus (HBV) viral load and transaminase enzymes in subjects with chronic HBV infection. Subjects and methods: Serum samples were collected from 256 participants with chronic HBV infection. The samples were obtained at the Gastroenterology Consulting Room, Outpatient Department, Bach Mai Hospital.
8p
visamoa2711
12-01-2021
13
2
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Interferon stimulated gene 20 (ISG20) plays an important role in viral infection and cancers. This study investigated the association between ISG20 rs4566136 polymorphism with HBV-related hepatocellular carcinoma (HCC).
8p
visamoa2711
12-01-2021
21
2
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This study was designed to investigate the impact of liver cirrhosis due to chronic hepatitis C virus (HCV) infection on the disease-free and overall survival of ovarian cancer patients undergoing a standard primary operation followed by standard chemotherapy.
7p
vimoscow2711
29-08-2020
12
1
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Approximately 250 million people worldwide are chronically infected with hepatitis B virus (HBV) and more than half of the hepatocellular carcinoma (HCC) cases are attributed to this infection. As HCC has a high mortality rate, and current treatment options are remarkably limited, the development of new therapeutic treatment strategies is warranted.
11p
vimale2711
21-08-2020
7
1
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Hepatitis B virus (HBV) is a DNA virus belonging to the Hepadnaviridae family that infect humans causing a disease infecting liver cells displaying a substantial hepatic tissue tropism, and inducing chronic liver damage and subsequent Hepato carcinogenesis. In Oncology patients receive packed red blood cell suspensions and other blood products regularly and they are in the high-risk group for infections due to these viruses.
6p
angicungduoc5
12-06-2020
17
0
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Viral infections account for significant proportion of CLD. Hepatitis C virus is the major cause of non-A, non-B hepatitis worldwide. HCV can lead to chronic liver disease causing cirrhosis, hepatocellular carcinoma and end stage liver disease among 5-20% of infected persons. In India about 20 million people are known to have HCV infection and a quarter of them are expected to develop chronic liver disease in the next 10-15 years. 1) To determine prevalence of Hepatitis C virus infection in chronic liver disease patients. 2) To identify the risk factor for HCV infection.
9p
nguathienthan5
04-06-2020
17
1
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The term viral hepatitis refers to primary infection of liver by any one of the heterogeneous group of hepatitis virus which currently consists of types A, B, C, D, E and G Hepatitis virus infection occurs as an acute illness. HBsAg (Hepatitis B surface antigen) is the most common marker of infection, which is present in high concentrations in early acute infections and is continued to be produced in chronic disease. The present study is undertaken because there is paucity of data indicating prevalence of Hepatitis B and Hepatitis C among pre-operative patients admitted in our hospital.
5p
nguaconbaynhay1
04-12-2019
23
0
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In this review, the clinical manifestations of urinary schistosomiasis are displayed from a pathogenetic perspective. According to the prevailing host’s immune response profile, urinary schistosomiasis may be broadly categorized into cell-mediated and immune-complex-mediated disorders. The former, usually due to Schistosoma haematobium infection, are attributed to the formation of granulomata along the entire urinary tract. As they heal with excessive fibrosis, they may lead to strictures, calcifications and urodynamic abnormalities.
7p
kethamoi1
17-11-2019
23
0
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Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Currently, combined pegylated interferon and ribavirin therapy are the standard treatment. The biological activity of interferon (IFN) is mediated by the induction of intracellular antiviral proteins, such as 20 –50 oligoadenylate synthetase, and dsRNA-activated protein kinase. IFN-inducible doublestranded RNA-activated protein kinase (PKR) is thought to play a key antiviral role against HCV. Some studies observed that PKR expression was higher in sustained viral responders compared with the non-responders.
7p
kethamoi1
17-11-2019
14
1
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Both Helicobacter pylori (HP) and hepatitis C virus (HCV) infections are endemic in Egypt. This work aimed to investigate the presence of HP in the liver of patients with chronic hepatitis C (CHC) and explore the relation between HP infection, liver histopathology and HCV viral load. The study included 60 patients with CHC. Virological, biochemical, liver biopsy and testing for anti-Hp and anti-schistosomal antibodies in serum were done. Liver tissues were examined for histopathological and presence of Hp by detection of HP 16S rRNA gene by PCR and sequence analysis.
7p
kethamoi1
17-11-2019
22
0
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Chronic hepatitis C virus (HCV) infection is a systemic disease that leads to increased risks of cirrhosis and its complications, as well as extrahepatic disturbances, including immune-related disorders and metabolic alterations such as insulin resistance and steatosis. Recent accumulating evidence suggests that HCV infection can increase cardiovascular risk, and that viral eradication can improve cardiovascular outcomes in the clinical setting. These data are strengthened by evidence identifying potential mechanisms (in)directly linking HCV infection to vascular damage.
8p
kequaidan1
16-11-2019
12
0
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Most chronic hepatitis B (CHB) patients in China are primitively treated with a combination of lamivudine (LAM) and adefovir dipivoxil (ADV). Although antiviral resistance can be avoided with this combination therapy, using it can have harmful side effects related to ADV, specifically kidney and bone injury.
6p
vinasaki2711
12-11-2019
8
0
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Hepatitis delta virus (HDV) is a defective virus that requires the hepatitis B virus (HBV) to complete its life cycle in human hepatocytes. HDV virions contain an envelope incorporating HBV surface antigen protein and a ribonucleoprotein containing the viral circular single-stranded RNA genome associated with both forms of hepatitis delta antigen, the only viral encoded protein. Replication is mediated by the host cell DNA-dependent RNA polymerases. HDV infects up to72 million people worldwide and is associated with an increased risk of severe and rapidly progressive liver disease.
13p
caygaocaolon1
13-11-2019
39
1
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