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Cisplatin in rats
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In study "Melatonin ameliorates cisplatin-induced neurodegeneration in medulla oblongata through the expressions of Aqp-1,-4, inflammation, and apoptosis pathway genes", the neuroprotective effects of melatonin (MEL) with changes in apoptosis, inflammation, and histopathological morphology were evaluated in the medulla oblongata of cisplatin (CIS) administered rats. Although the side effects of CIS are known in many tissues, its reaction on the medulla oblongata and the molecular association underlying this effect is unclear.
11p
lyhuyenthu
31-01-2023
8
2
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Gentamicin (GM) is a low-cost, low-resistance antibiotic commonly used to treat gram-negative bacterial diseases. Cisplatin (Csp) is a platinum-derived anti-neoplastic agent. This experiment aimed to identify the early signs of gentamicin and cisplatin-induced nephrotoxicity in rats.
9p
vidarwin
22-02-2022
12
1
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Cisplatin (CP) is considered one of the most effective and widely used anti-neoplastic drug in the treatment of different solid organ tumors. The present study was carried out to assess the hematological changes following CP administration in Wistar albino rats and its amelioration by extract of Andrographis paniculata (AP). The study included 60 Wistar albino rats were divided into 12 rats in each group. Group I served as normal control group.
8p
angicungduoc6
22-07-2020
8
1
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Cisplatin (CP), an effective anticancer agent, carries the risk of impairing testicular function leading to infertility. The present study aimed at evaluating the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP-induced oxidative stress and testicular injuries in rats.
14p
vibaku2711
22-07-2020
14
1
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The role of ethanolic extract of Andrographis paniculata (AP), in preventing cisplatin (CP) induced oxidative damage in rat liver was studied. The study included 60 Wistar albino rats were divided into 12 rats in each group. Group I served as normal control group. To group II rats, CP was administered at 7.5mg/kg body weight intraperitoneally for single dose. Rats in group III were administered AP at the dose of 500mg/kg body weight for 45 days. Group IV rats were pre-treated with AP 15 days prior to CP administration and followed by AP treatment for 45 days.
10p
chauchaungayxua4
18-03-2020
16
2
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Inhibiting ceramidase activity in cancer cells has been identified as a promising target for cancer therapy in recent studies. Thus, we examined the possible role of ceranib-2, a novel ceramidase inhibitor, on growth and apoptotic mechanisms of the human normal glia cell line (HNA), human glioma cell lines (T-98G and U-87MG), and a rat glioma cell line (C6).
7p
nutifooddau
27-01-2019
18
1
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