Claudin 1 protein

PIKfyve is an evolutionarily conserved lipid and protein kinase enzyme that has pleiotropic cellular functions. The aim of the present study was to investigate the effects of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) inhibitor, YM201636, on nonsmall cell lung cancer (NSCLC) cells growth, tumorigenicity, and claudin (CLDN) expressions. Three NSCLC cell lines (Calu-1, H1299 and HCC827) were used to compare the effects of YM201636. Cytotoxic effects of YM201636 were analysed using XTT assay.

9p thiencuuchu 27-11-2021 10 1   Download

Defects in tight junctions, gate-keepers of the integrity of the epidermal barrier function, are known to contribute to cancer development. As such, enhancing our understanding of how the expression of proteins involved in these junctions is regulated in cancer, remains a priority.

13p vijennie2711 29-09-2020 10 1   Download

Several studies have shown that the immunophenotype of distant breast cancer metastases may differ significantly from that of the primary tumor, especially with regard to differences in the level of hormone receptor protein expression, a process known as receptor conversion.

6p vilisa271 22-09-2020 10 1   Download

A novel hypoxically regulated intercellular junction protein (claudin-like protein of 24 kDa, CLP24) hasbeen identified that shows homology to the myelin protein 22/epithelial membrane protein 1/claudin family of cell junction proteins, which are involved in the modulation of paracellular per-meability. The CLP24 protein containsfour predicted transmembrane domains and a C-terminal protein–protein interaction domain.

9p dell39 03-04-2013 43 4   Download