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Clinical finding
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Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are the two most common immune checkpoints targeted in triple-negative breast cancer (BC). Refining patient selection for immunotherapy is non-trivial and finding an appropriate digital pathology framework for spatial analysis of theranostic biomarkers for PD-1/PD-L1 inhibitors remains an unmet clinical need.
11p
vishanshan
27-06-2024
1
1
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In Africa, the delivery of HIV pre-exposure prophylaxis (PrEP) at public healthcare clinics is challenged by understaffing, overcrowding, and HIV-associated stigma, often resulting in low PrEP uptake and continuation among clients. Giving clients the option to refill PrEP at nearby private pharmacies, which are often more convenient and have shorter wait times, may address these challenges and improve PrEP continuation.
10p
vishanshan
27-06-2024
2
1
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This paper attempted to clarify the role and mechanism of vacuolar protein sorting-associated protein 72 homolog (VPS72) in the progression of prostate cancer (PCa). In summary our findings suggests that VPS72 could play a crucial role in the malignant progression of PCa, and its expression level can be employed as a possible biomarker of PCa prognosis.
11p
vikoch
27-06-2024
2
1
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Carcinoma of unknown primary origin (CUP) is a metastatic carcinoma in which the primary tumor remains elusive even after evaluation of the clinical history, physical examination, radiological findings, laboratory tests and other diagnostic investigations.
12p
vikoch
27-06-2024
2
1
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To compare some of clinical features, laboratory finding and treament of severe pneumonia caused by bacteria, virus and bacteria-virus coinfections based on PCR (Polymerase Chain Reaction) results NTA (Naso tracheal aspiration), and rapid test to finding RSV, AdV results in children from 2 months to 24 months hospitalized at the Respiratory Department of Children’s Hospital 1.
11p
vicarlos
11-06-2024
0
0
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A descriptive study was carried out in all B-NHL patients under 16 years old that start their treatment in VNCH since 01 January 2015 and end before 30 June 2021, excluding patients can’t follow up. This study aims to review some clinical characteristics and investigation findings of B-NHL patients at the Vietnam National Children’s Hospital.
8p
vicarlos
11-06-2024
0
0
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Ebook Adams and Victor's principles of neurology is truly the classic text in its discipline - a celebrated volume that guides clinicians to an in-depth understanding of the key aspects of neurologic disease, including both clinical and new scientific data. This meticulously revised and updated text remains the masterwork in its field, and the most readable reference available. Within its pages, you will find a disciplined presentation of clinical data and lucid descriptions of underlying disease processes.
823p
vimeyers
29-05-2024
3
1
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Established for more than 75 years, Ebook The Washington manual of medical therapeutics, 36th edition, provides concise, high-yield content that reflects today’s fast-changing advances in medical technology and therapeutics. In one convenient, portable resource, you’ll find complete coverage of every area of medicine and the core subspecialties—all at your fingertips for quick review and reference. Discover why housestaff and faculty worldwide depend on this best-selling resource for day-to-day clinical practice in internal medicine.
3623p
vimeyers
29-05-2024
4
2
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Duodenal diverticulum is a relatively common finding that can be incidentally found in upper gastrointestinal endoscopy in up to 20% of cases. Most duodenal diverticula are asymptomatic, and perforation of a duodenal diverticulum is extremely rare.
4p
viambani
21-05-2024
3
1
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To determine the correlation between clinical symptoms, computer tomography scan (CT-scan), and histopathologic findings of chronic rhinosinusitis (CRS). Methods: A prospective, case-by-case study on 33 patients with CRS who were diagnosed and treated by functional endoscopic sinus surgery at the Department of Otolaryngology, Military Hospital 103 from January 2022 to August 2022.
9p
vijaychest
16-05-2024
3
1
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Ebook "Targeted therapies in cancer: Myth or Reality?" contributes to improve our approach to cancer drug discovery and, ultimately, to find new, more efficacious and better tolerated drugs for cancer patients. It provides an overview of diverse approaches ranging from drug discovery to cellular therapy. Although this change in paradigm has been useful, its entry into the clinical arena was associates with unforeseen problems including the emergence of resistance, unexpected side effects and failures.
200p
ladongphongthanh1008
22-04-2024
7
1
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Ebook "Trends in stem cell biology and technology" highlight both of these aspects: that of understanding the “actual” and that of developing the “possible. ” In recognition of the growing excitement and potential of stem cells as models for both the advancement of basic science and future clinical applications, I felt it timely to edit this book in which forefront investigators would provide new findings for the use of stem cells to study various lineages and tissue types and some applications.
420p
ladongphongthanh1008
22-04-2024
6
2
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The specific objectives of this study are to have a better understanding of the current mental health status of primary caregivers of children with CP more specifically for depression, anxiety, quality of life, the coping strategies used by caregivers, the relations between caregivers’ mental health and coping as well as other associated factors. The research findings could serve as useful inputs for the development of relevant interventions to support caregivers of children with CP to improve their mental health.
254p
khanhchi0912
12-04-2024
5
1
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Clinical use of polygenic risk scores (PRS) will look very different to the more familiar monogenic testing. Here we argue that despite these differences, most of the ethical, legal, and social issues (ELSI) raised in the monogenic setting, such as the relevance of results to family members, the approach to secondary and incidental findings, and the role of expert mediators, continue to be relevant in the polygenic context, albeit in modified form.
10p
vibransone
28-03-2024
2
2
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We report the findings from 4437 individuals (3219 patients and 1218 relatives) who have been analyzed by whole genome sequencing (WGS) at the Genomic Medicine Center Karolinska-Rare Diseases (GMCKRD) since mid-2015.
15p
vibransone
28-03-2024
4
2
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Most two-group statistical tests find broad patterns such as overall shifts in mean, median, or variance. These tests may not have enough power to detect effects in a small subset of samples, e.g., a drug that works well only on a few patients.
19p
vibransone
28-03-2024
4
1
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The uptake of exome/genome sequencing has introduced unexpected testing results (incidental findings) that have become a major challenge for both testing laboratories and providers. While the American College of Medical Genetics and Genomics has outlined guidelines for laboratory management of clinically actionable secondary findings, debate remains as to whether incidental findings should be returned to patients, especially those representing pediatric populations.
17p
viellison
28-03-2024
4
2
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Ebook "Studies on periodontal disease (Oxidative stress in applied basic research and clinical practice series)" comprise four parts. Part 1 provides basic sciences from the general to the particular. The findings of cell culture and animal models supply the mechanism between periodontal disease and oxidative stress. In part 2, human clinical studies are mainly addressed. The effects of periodontal therapy on circulating oxidative stress are also discussed. The relationships between periodontal disease and systemic diseases are examined in part 3.
368p
manmanthanhla0201
26-02-2024
7
1
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Ebook Central pain syndrome: Pathophysiology, diagnosis, and management (Second edition) – Part 1 includes content: Introducing central pain, clinical features, somatosensory findings, central pruritus, natural history, diagnosing central pain, drug therapy,… and other contents.
199p
longtimenosee03
01-02-2024
7
0
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Ebook Bates’ poktet guide to physical examination and history taking (Seventh edition): Part 1 includes content: Clinical reasoning, assessment, and recording your findings; interviewing and the health history, behavior and mental status, the skin, hair, and nails, the cardiovascular system,… and other contents. Invite you to consult the details.
178p
longtimenosee03
01-02-2024
4
0
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