Clinical oncology
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Panel gene sequencing is an established diagnostic tool for precision oncology of solid tumors, but its utility for the treatment of cancers of the digestive system in clinical routine is less well documented.
10p vishanshan 27-06-2024 1 1 Download
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The rapid evolution, complexity, and specialization of oncology treatment makes it challenging for physicians to provide care based on the latest and best evidence. We hypothesized that physicians would use evidencebased trusted care pathways if they were easy to use and integrated into clinical workfow at the point of care.
8p vishanshan 27-06-2024 2 1 Download
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Patient-centredness has become a central quality indicator for oncology care. Elements include shared decision-making, patient navigation and integration of psychosocial care, which impact patient-reported and clinical outcomes. Despite efforts to promote patient-centred care in Germany in recent decades, implementation remains fragmented.
10p vishanshan 27-06-2024 2 1 Download
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The novel oncologic PET-tracer fibroblast activation protein inhibitor (FAPI) has demonstrated promising results in multiple cancer types, including ovarian cancer, and could overcome the limitations of [18F]FDG PET; however, high-quality clinical studies are lacking.
9p vikoch 27-06-2024 2 1 Download
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This paper responds to the recently published article by Wang et al. and will expand the discourse regarding management of localized MCC. Specifically, we will discuss the surgical excision approaches; alternative treatment options for MCC including radiotherapy, Mohs micrographic surgery and novel immunotherapy agents being investigated through several clinical trials.
3p vikoch 27-06-2024 2 1 Download
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High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting.
18p vikoch 27-06-2024 1 1 Download
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Part 2 book "Internal medicine" includes content: Hematology oncology, rheumatology, nephrology, endocrinology, infectious disease, dermatology, clinical vignettes review. All concepts are presented in a question and answer format that covers the key facts on hundreds of commonly tested internal medicine topics that may appear on the USMLE Step 2CK exam.
136p zizaybay1101 30-04-2024 3 2 Download
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Part 2 book "Essentials of internal medicine" includes content: Hepatology; hematology; oncology; palliative medicine; immunology; musculoskeletal medicine; neurology; psychiatry for the internist; clinical infectious diseases; immunization; dermatology for the physician; medical ophthalmology; women’s health for the physician; obstetric medicine; geriatric medicine.
438p muasambanhan10 11-04-2024 3 1 Download
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Part 2 book "Molecular diagnostics - Fundamentals, methods, and clinical applications" includes content: DNA polymorphisms and human identifi cation, detection and identifi cation of microorganisms; molecular detection of inherited diseases, molecular oncology, DNA based tissue typing, quality assurance and quality control in the molecular laboratory.
303p muasambanhan10 06-04-2024 3 0 Download
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Although large-scale, next-generation sequencing (NGS) studies of cancers hold promise for enabling precision oncology, challenges remain in integrating NGS with clinically validated biomarkers. To overcome such challenges, we utilized the Database of Evidence for Precision Oncology (DEPO) to link druggability to genomic, transcriptomic, and proteomic biomarkers.
20p vibransone 28-03-2024 3 2 Download
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A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting genomic data is hindering the implementation of high-throughput technologies in the clinical context: increasing evidence on gene–drug interactions complicates the task of assigning clinical significance to genomic variants.
15p vibransone 28-03-2024 3 2 Download
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Circulating tumour DNA (ctDNA) detection and monitoring have enormous potential clinical utility in oncology. We describe here a fast, flexible and cost-effective method to profile multiple genes simultaneously in low input cell-free DNA (cfDNA).
14p vibransone 28-03-2024 5 2 Download
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Circulating tumor (ct) DNA is a powerful tool that can be used to track cancer beyond a single snapshot in space and time. It has potential applications in detecting minimal residual disease and predicting relapse, in selecting patients for tailored treatments, and in revealing mechanisms of response or resistance. Here, we discuss the incorporation of ctDNA into clinical trials.
4p vibransone 28-03-2024 4 2 Download
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Precision oncology involves analysis of individual cancer samples to understand the genes and pathways involved in the development and progression of a cancer. To improve patient care, knowledge of diagnostic, prognostic, predisposing, and drug response markers is essential.
16p vibransone 28-03-2024 4 2 Download
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High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remaining uncertainty on its originating tissue has hampered the discovery of molecular oncogenic pathways and the development of effective therapies.
20p vibransone 28-03-2024 7 2 Download
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The diversity of clinical tumor profiling approaches (small panels to whole exomes with matched or unmatched germline analysis) may engender uncertainty about their benefits and liabilities, particularly in light of reported germline false positives in tumor-only profiling and use of global mutational and/or neoantigen data.
10p vioraclene 31-03-2024 2 2 Download
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To truly achieve personalized medicine in oncology, it is critical to catalog and curate cancer sequence variants for their clinical relevance. The Somatic Working Group (WG) of the Clinical Genome Resource (ClinGen), in cooperation with ClinVar and multiple cancer variant curation stakeholders, has developed a consensus set of minimal variant level data (MVLD).
9p vioraclene 31-03-2024 3 1 Download
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Molecular characterization has the potential to advance the management of pediatric cancer and high-risk hematologic disease. The clinical integration of genome sequencing into standard clinical practice has been limited and the potential utility of genome sequencing to identify clinically impactful information beyond targetable alterations has been underestimated.
19p vioraclene 31-03-2024 4 2 Download
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Profiling the somatic mutations of genes which may inform about tumor evolution, prognostics and treatment is becoming a standard tool in clinical oncology. Commercially available cancer gene panels rely on manually gathered cancer-related genes, in a “one-size-fits-many” solution.
9p vioraclene 31-03-2024 3 2 Download
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Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy.
22p vioraclene 31-03-2024 2 2 Download