Clinical research informatics
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Part 1 book "Mouse as a model organism" includes content: Genomic insulators in transgenic animals, the german mouse clinic running an open access platform, nature and nurture - impacts on mouse phenotypes and translational research, the informatics of high throughput mouse phenotyping - Eumodic and beyond.
104p muasambanhan03 25-12-2023 2 1 Download
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Our objective is to test the limits of the assumption that better learning from data in medicine requires more granular data. We hypothesize that clinical trial metadata contains latent scientific, clinical, and regulatory expert knowledge that can be accessed to draw conclusions about the underlying biology of diseases.
11p visteverogers 24-06-2023 4 2 Download
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Phenotyping algorithms applied to electronic health record (EHR) data enable investigators to identify large cohorts for clinical and genomic research. Algorithm development is often iterative, depends on fallible investigator intuition, and is time- and labor-intensive.
10p visteverogers 24-06-2023 11 4 Download
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To report on the state of the science of clinical decision support (CDS) for hospital bedside nurses. Materials and Methods: We performed an integrative review of qualitative and quantitative peer-reviewed original research studies using a structured search of PubMed, Embase, Cumulative Index to Nursing and Applied Health Literature (CINAHL), Scopus, Web of Science, and IEEE Xplore (Institute of Electrical and Electronics Engineers Xplore Digital Library).
10p visteverogers 24-06-2023 10 3 Download
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The field of biomedical informatics experienced a productive 2015 in terms of research. In order to highlight the accomplishments of that research, elicit trends, and identify shortcomings at a macro level, a 19-person team conducted an extensive review of the literature in clinical and consumer informatics.
6p visteverogers 24-06-2023 4 3 Download
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Hospital-acquired pressure ulcers (HAPUs) have a mortality rate of 11.6%, are costly to treat, and result in Medicare reimbursement penalties. Medicare codes HAPUs according to Agency for Healthcare Research and Quality Patient-Safety Indicator 3 (PSI-03), but they are sometimes inappropriately coded.
8p visteverogers 24-06-2023 3 3 Download
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Implementation of patient preferences for use of electronic health records for research has been traditionally limited to identifiable data. Tiered e-consent for use of de-identified data has traditionally been deemed unnecessary or impractical for implementation in clinical settings.
8p visteverogers 24-06-2023 2 2 Download
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The repurposing of electronic health records (EHRs) can improve clinical and genetic research for rare diseases. This paper presents a method to detect family history and negation in narrative reports and evaluates its impact on selecting populations from a clinical data warehouse (CDW).
7p visteverogers 24-06-2023 2 2 Download
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To assess and refine competencies for the clinical research data management profession. Materials and Methods: Based on prior work developing and maintaining a practice standard and professional certification exam, a survey was administered to a captive group of clinical research data managers to assess professional competencies, types of data managed, types of studies supported, and necessary foundational knowledge.
9p visteverogers 24-06-2023 3 2 Download
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To investigate time differences in recording observations and an early warning score using traditional paper charts and a novel e-Obs system in clinical practice. Methods: Researchers observed the process of recording observations and early warning scores across 3 wards in 2 university teaching hospitals immediately before and after introduction of the e-Obs system.
5p visteverogers 24-06-2023 2 2 Download
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It is critical to integrate and analyze data from biological, translational, and clinical studies with data from health systems; however, electronic artifacts are stored in thousands of disparate systems that are often unable to readily exchange data.
9p visteverogers 24-06-2023 4 2 Download
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Pragmatic (trial) informatics: A perspective from the NIH Health Care Systems Research Collaboratory
Pragmatic clinical trials (PCTs) are research investigations embedded in health care settings designed to increase the efficiency of research and its relevance to clinical practice. The Health Care Systems Research Collaboratory, initiated by the National Institutes of Health Common Fund in 2010, is a pioneering cooperative aimed at identifying and overcoming operational challenges to pragmatic research.
6p visteverogers 24-06-2023 4 2 Download
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To develop an open-source information extraction system called Eligibility Criteria Information Extraction (EliIE) for parsing and formalizing free-text clinical research eligibility criteria (EC) following Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) version 5.0.
10p visteverogers 24-06-2023 11 2 Download
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PEDSnet is a clinical data research network (CDRN) that aggregates electronic health record data from multiple children’s hospitals to enable large-scale research. Assessing data quality to ensure suitability for conducting research is a key requirement in PEDSnet.
8p visteverogers 24-06-2023 3 2 Download
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To describe nurses’ preferences for the design of a probability-based clinical decision support (PB-CDS) tool for in-hospital clinical deterioration. Methods: A convenience sample of bedside nurses, charge nurses, and rapid response nurses (n ¼ 20) from adult and pediatric hospitals completed participatory design sessions with researchers in a simulation laboratory to elicit preferred design considerations for a PB-CDS tool.
9p visteverogers 24-06-2023 8 3 Download
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Critical appraisal of clinical evidence promises to help prevent, detect, and address flaws related to study importance, ethics, validity, applicability, and reporting. These research issues are of growing concern. The purpose of this scoping review is to survey the current literature on evidence appraisal to develop a conceptual framework and an informatics research agenda.
12p visteverogers 24-06-2023 7 2 Download
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One promise of nationwide adoption of electronic health records (EHRs) is the availability of data for large-scale clinical research studies. However, because the same patient could be treated at multiple health care institutions, data from only a single site might not contain the complete medical history for that patient, meaning that critical events could be missing.
8p visteverogers 24-06-2023 6 2 Download
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T Objective: Alert fatigue limits the effectiveness of medication safety alerts, a type of computerized clinical decision support (CDS). Researchers have suggested alternative interactive designs, as well as tailoring alerts to clinical roles. As examples, alerts may be tiered to convey risk, and certain alerts may be sent to pharmacists.
9p visteverogers 24-06-2023 3 2 Download
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Complaints about electronic health records, including information overload, note bloat, and alert fatigue, are frequent topics of discussion. Despite substantial effort by researchers and industry, complaints continue noting serious adverse effects on patient safety and clinician quality of life.
6p visteverogers 24-06-2023 3 2 Download
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The study sought to design, pilot, and evaluate a federated data completeness tracking system (CTX) for assessing completeness in research data extracted from electronic health record data across the Accessible Research Commons for Health (ARCH) Clinical Data Research Network.
9p visteverogers 24-06-2023 6 2 Download