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Clinical trial registry
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Aboriginal and Torres Strait Islander peoples (hereafter respectfully referred to as Indigenous Australians) represent about 3% of the total Australian population. Major health disparities exist between Indigenous and Non-Indigenous Australians. To address this, it is vital to understand key health priorities and knowledge gaps in the current landscape of clinical trial activity focusing on Indigenous health in Australia.
11p
viferrari
28-11-2022
10
2
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Acute promyelocytic leukemia (APL) is considered a hematologic emergency due to high risk of bleeding and fatal hemorrhages being a major cause of death. Despite lower death rates reported from clinical trials, patient registry data suggest an early death rate of 20%, especially for elderly and frail patients.
11p
vikolindagrabar
27-07-2022
6
2
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We report here the first population-based incidence rates and prognosis of primary central nervous system lymphoma (PCNSL) in Finland. Methods: Finnish Cancer Registry data by histological diagnosis and tumor location (2007–2017) for cases with diffuse large B-cell lymphoma.
8p
vikolindagrabar
27-07-2022
5
2
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Real-world data (RWD) is increasingly being embraced as an invaluable source of information to address clinical and policy-relevant questions that are unlikely to ever be answered by clinical trials. However, the largely unrealised potential of RWD is the value to be gained by supporting prospective studies and translational research.
9p
visusanwojcicki
28-06-2022
10
2
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We have performed a head to head comparison of all-oral triplet combination of ixazomib, lenalidomide and dexamethasone (IRD) versus lenalidomide and dexamethasone (RD) in patients with relapsed and refractory multiple myeloma (RRMM) in the routine clinical practice.
13p
vianrose2711
27-04-2021
15
1
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Spinal stenosis is a clinical diagnosis in which the main symptom is pain radiating to the lower extremities, or neurogenic claudication. Radiological spinal stenosis is commonly observed in the population and it is debated whether patients with no lower extremity pain should be labelled as having spinal stenosis.
8p
vivermont2711
28-01-2021
10
1
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Clinical trial registries may allow for producing a global mapping of health research. However, health conditions are not described with standardized taxonomies in registries. Previous work analyzed clinical trial registries to improve the retrieval of relevant clinical trials for patients.
14p
vioklahoma2711
19-11-2020
6
1
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Few targeted therapies (TTs) are registered for sarcoma treatment despite numerous phase II studies and yet there are potential treatment options for patients after standard treatment escape. The French Sarcoma Group - Bone Tumor Study Group (GSF-GETO) created a national registry to evaluate the outcome of patients treated with off-label TTs.
11p
vilisa271
22-09-2020
12
1
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It is well known that patient characteristics and survival outcomes in randomized trials may not necessarily be similar to those in real-life clinical practice. The aim of the present study was to analyse second line treatment strategies in the real-world practice and to estimate the outcomes of patients treated with second-line targeted therapy for metastatic renal cell carcinoma (mRCC).
8p
vibaku2711
22-07-2020
13
3
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Population-based estimates of the long-term risk of loco-regional recurrence and distant metastases of breast cancer (BRC) patients are scant, as most published studies used hospital-based cohorts or participants of clinical trials.
14p
vikuala271
13-06-2020
8
1
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Registering clinical trials (CTs) in public domains enhances transparency, increases trust in research, improves participation and safeguards against publication bias. This work was done to study the profile of clinical research in Egypt in three CT registries with different scopes: the WHO International CT Registry Platform (ICTRP), the continental Pan-African CT Registry (PACTR) and the US clinicaltrials.gov (CTGR). In March 2014, ICTRP, PACTR and CTGR were searched for clinical studies conducted in Egypt. It was found that the number of studies conducted in Egypt (percentage) was 686 (0.
9p
kequaidan1
16-11-2019
9
1
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Risk of hospitalized infections under biologics among patients suffering from chronic inflammatory autoimmune diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PSA), or psoriasis was investigated using administrative data. The hospital discharge records database, the medical prescription database, and the database of exemptions from medical charges were linked at the individual patient level.
7p
trinhthamhodang1
14-11-2019
16
0
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Survival statistics can be produced by population-based cancer reg- istries that follow up their cases, either actively or passively. Although survival analysis of data from population-based registries cannot evaluate specific treatments (this can be done only in clinical randomized trials), it provides a useful evaluation of cancer care in the area covered by the registry, since all cancer cases will be included regardless of the type of treatment they may have received. The methods used in survival analyses are those discussed in Chapter 12.
11p
taisaokhongthedung
09-01-2013
63
2
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Neither randomized clinical trials nor meta- analysis are available and evidence is based on a number of retrospective studies with multivariate for mortality risk factors or data from national cancer registries (Gilliland et al., 1997; Hundahl et al., 1998). Unfortunately, very remarkable differences in patient’s selection, staging systems, and clinical management affect the available studies. In particular, radioiodine treatment is not routinely carried out in a standard manner and outcome results of different studies are thus not comparable (Sciuto et al., 2009).
180p
wqwqwqwqwq
20-07-2012
82
6
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Sources of Evidence: Clinical Trials and Registries The notion of learning from observation of patients is as old as medicine itself. Over the last 50 years, our understanding of how best to turn raw observation into useful evidence has evolved considerably. Case reports, personal anecdotal experience, and small single-center case series are now recognized as having severe limitations to validity and have no role in formulating modern standards of practice. The major tools used to develop reliable evidence consist of the randomized clinical trial and the large observational registry.
6p
tubreakdance
26-11-2010
91
7
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