Coagulation activity
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Coagulation and fibrinolysis are distinct processes that are highly correlated. Cells control coagulation and fibrinolysis by expression of tissue factor and urokinase-type plasminogen activator receptor on their surface.
12p vialfrednobel 23-12-2023 4 3 Download
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Abelson (ABL) tyrosine kinase inhibitors (TKIs) are effective against chronic myeloid leukemia (CML); however, many patients develop resistance during ABL TKI therapy. Vitamin K2 (VK2) is a crucial fat-soluble vitamin used to activate hepatic coagulation factors and treat osteoporosis.
11p vioracle 29-09-2023 4 2 Download
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Antithrombin III (AT III) is a critical component of the coagulation cascade that functions primarily to inhibit activated coagulation factors IIa and Xa. AT III deficiency is a disorder that predisposes patients to thromboemboli. Antiphospholipid syndrome (APS) is an autoimmune disorder that predisposes patients to vascular and microvascular thrombosis, which can often be devastating and lead to multiorgan involvement.
5p viintuit 26-09-2023 2 0 Download
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The Peuhl cheese (Waragashi, Warangachi, Wagashi, or Wara in local language) is a soft cheese with a high nutritional value, prepared by coagulation of whole milk under the action of calotropaïne, a plant enzyme from Calotropis procera. In this study, Plumeria alba latex has been used as an alternative source of enzymes for the production of Waragashi cheese.
6p viisac 23-09-2023 2 1 Download
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The clotting or hemostasis system is a meticulously regulated set of enzymatic reactions that occur in the blood and culminate in formation of a fibrin clot. The precisely calibrated signaling system that prevents or initiates clotting originates with the activated Factor Seven (FVIIa) complexed with tissue factor (TF) formed in the endothelium.
9p videadpool 05-05-2023 4 2 Download
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This work demonstrated the potential of US for mitigating membrane fouling. However, the integration of the US transducers within the membrane system will be a major challenge for the application of US in membrane cleaning. It is more appropriate that US is used as pre-treatment to the membrane system, the transducers can be placed prior to the coagulant feed line. Further work on the determination of the detailed mechanisms associated with enhancing coagulation would enable optimisation of the system with regard to process, cost and energy efficiency.
108p runthenight05 01-03-2023 5 2 Download
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Ideal wound dressings should be biocompatible, exhibit high antibacterial activity, and promote blood coagulation. To impart these imperative functions, carboxymethyl-kappa-carrageenan was incorporated into poly (vinyl alcohol) nanofibers (PVA-CMKC).
12p viginny 30-12-2022 10 2 Download
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Previous studies have shown that sugammadex resulted in the prolongation of prothrombin time and activated partial thromboplastin time. In this study, we aimed to investigate the in vitro effects of exogenous sugammadex on the coagulation variables of whole blood in healthy patients who underwent orthopedic surgery.
6p vampires36 30-12-2021 6 0 Download
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Hemostasis is the dynamic equilibrium between coagulation and fibrinolysis. During pregnancy, the balance shifts toward a hypercoagulative state; however placental abruption and abnormal placentations may lead to rapidly evolving coagulopathy characterized by the increased activation of procoagulant pathways.
8p vizhangzhidong 29-12-2021 11 0 Download
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The disease is characterized by necrotizing inflammation of small vessels causing tissue ischemia in a variety of organs. The aim of the present study was an evaluation of inflammation, coagulation and fibrinolysis biomarkers, and their possible associations with various clinical and laboratory parameters in GPA patients.
5p lazzaro 30-12-2021 5 0 Download
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Abnormal activation of the coagulation system has been reported in patients with malignancies, but its prognostic significance in biliary tract cancer (BTC) remains unclear. This study aims to analyze and compare the prognostic value of coagulation indices in patients with BTC.
15p vimahuateng 26-11-2021 6 1 Download
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The purposes of the dissertation: Preparation of low molecular weight sodium alginate from brown algae in Nha Trang Bay which has anticoagulant activity as a raw material for functional food production.
36p tunelove 11-06-2021 20 2 Download
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The tissue factor (TF)-dependent extrinsic pathway has been suggested to be a central mechanism by which the coagulation cascade is locally activated in the lungs of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) and thus represents an attractive target for therapeutic intervention.
8p vianthony2711 16-04-2021 12 2 Download
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Inhalation of particulate matter, as part of air pollution, is associated with increased morbidity and mortality. Nanoparticles (< 100 nm) are likely candidates for triggering inflammatory responses and activation of coagulation pathways because of their ability to enter lung cells and pass bronchial mucosa.
10p vimaine2711 26-03-2021 8 1 Download
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The procoagulant state in cancer increases the thrombotic risk, but also supports tumor progression. To investigate the molecular mechanisms controlling cancer and hemostasis, we conducted a case-control study of genotypic and phenotypic variables of the tissue factor (TF) pathway of coagulation in breast cancer.
11p vilisa271 22-09-2020 14 1 Download
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Coagulation and fibrinolysis activation is frequently observed in cancer patients, and the tumors in these cases are thought to be associated with a higher risk of invasion, metastasis, and worse long-term outcome.
12p vilisa271 22-09-2020 6 0 Download
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Tissue Factor (TF) forms a proteolytically active complex together with coagulation factor VIIa (FVIIa) and functions as the trigger of blood coagulation or alternatively activates cell signaling. We recently described that EphA2 of the Eph tyrosine kinase receptor family is cleaved directly by the TF/FVIIa complex.
14p vinaypyidaw2711 26-08-2020 11 2 Download
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Although Asian population was recognized to have a lower risk of venous thromboembolism (VTE), its increasing prevalence and incidence remain unclear in patients with malignancies. We attempted to predict VTE development using activation markers of coagulation and fibrinolysis.
8p vidhaka2711 31-07-2020 16 1 Download
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Microvesicles are small vesicles expressing specific antigens from their cells of origin. Elevated levels of microvesicles have been shown to be associated with coagulation disorders as well as with different types of malignancies.
11p vidhaka2711 31-07-2020 8 1 Download
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In dairy industry whey is a by-product during the manufacture of coagulated milk products such as paneer, channa, casein etc. Bioactive peptides produced by the fermentation of the whey have various biofunctional properties. The ACE inhibitory activity of cultured buttermilk prepared by addition of 40% fermented whey (RT3), 30% fermented whey (RT4) and control (RT5) were found to be 69.24, 64.50 and 57.63 per cent respectively.
13p nguaconbaynhay6 24-06-2020 11 1 Download