Coding sequences
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Ebook Fundamentals of cryptology: A professional reference & interactive tutorial presents the following content: Chapter 1 introduction, chapter 2 classical cryptosystems, chapter 3 shift register sequences, chapter 4 block ciphers, chapter 5 shannon theory, chapter 6 data compression techniques, chapter 7 public-key cryptography, chapter 8 discrete logarithm based systems, chapter 9 RSA based systems, chapter 10 elliptic curves based systems, chapter 11 coding theory based systems, chapter 12 knapsack based systems.
508p zizaybay1103 29-05-2024 5 2 Download
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In this study, we conducted sequencing of the entire gene coding region (WES) in the patient and identified a compound heterozygote variants (c.289C>G, p.Arg97Gly and c.433C>T, p.Arg145Trp) in the TNNI3 gene. These variants were inherited from the patient's father and mother, who were heterozygous variant carriers. These variants were also identified as the pathogenic variants in the ClinVar database (accession number VCV001331910.2 and VCV000012426.28, respectively) and were the cause of the patient's disease.
12p dianmotminh02 03-05-2024 1 1 Download
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Part 1 of ebook "Software engineering, artificial intelligence, networking and parallel/distributed computing 2011" includes the following main contents: analysis of ISSP environment II survey data using variable clustering; polar transformation system for offline handwritten character recognition; examining QoS guarantees for real-time CBR services in broadband wireless access networks; sin and sigmoid higher order neural networks for data simulations and predictions; a proposal of mouth shapes sequence code for Japanese pronunciation;...
90p khuynhlinhnguyet1009 05-04-2024 3 1 Download
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Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored.
19p vibransone 28-03-2024 3 2 Download
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The American College of Medical Genetics and Genomics (ACMG)/Association for Molecular Pathology (AMP) clinical variant interpretation guidelines established criteria for different types of evidence. This includes the strong evidence codes PS3 and BS3 for “well-established” functional assays demonstrating a variant has abnormal or normal gene/protein function, respectively.
12p vibransone 28-03-2024 3 2 Download
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The concentrations of the highly atherogenic lipoprotein(a) [Lp(a)] are mainly genetically determined by the LPA gene locus. However, up to 70% of the coding sequence is located in the complex so-called kringle IV type 2 (KIV-2) copy number variation, a region hardly accessible by common genotyping and sequencing technologies.
13p vibransone 28-03-2024 3 2 Download
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The identification of functional non-coding mutations is a key challenge in the field of genomics. Here we introduce μ-cisTarget to filter, annotate and prioritize cis-regulatory mutations based on their putative effect on the underlying “personal” gene regulatory network.
13p vioraclene 31-03-2024 4 2 Download
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Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the NaV1.1 sodium channel alpha subunit, is one such gene with two co-active promoters.
22p vibransone 28-03-2024 5 2 Download
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The majority of clinical genetic testing focuses almost exclusively on regions of the genome that directly encode proteins. The important role of variants in non-coding regions in penetrant disease is, however, increasingly being demonstrated, and the use of whole genome sequencing in clinical diagnostic settings is rising across a large range of genetic disorders.
19p viellison 28-03-2024 4 2 Download
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Structural variants (SVs) are implicated in the etiology of Mendelian diseases but have been systematically underascertained owing to sequencing technology limitations. Long-read sequencing enables comprehensive detection of SVs, but approaches for prioritization of candidate SVs are needed.
13p viellison 28-03-2024 5 1 Download
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Whole genome sequencing is increasingly being used for the diagnosis of patients with rare diseases. However, the diagnostic yields of many studies, particularly those conducted in a healthcare setting, are often disap‑ pointingly low, at 25–30%. This is in part because although entire genomes are sequenced, analysis is often confined to in silico gene panels or coding regions of the genome.
25p vicwell 29-02-2024 3 1 Download
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5’ untranslated regions (5’UTRs) are essential modulators of protein translation. Predicting the impact of 5’UTR variants is challenging and rarely performed in routine diagnostics. Here, we present a combined approach of a comprehensive prioritization strategy and functional assays to evaluate 5’UTR variation in two large cohorts of patients with inherited retinal diseases (IRDs).
21p vicwell 29-02-2024 3 1 Download
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Dose-limiting toxicities significantly impact the benefits/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities. Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting neurological toxicity of chemotherapies with no effective approach for prevention.
15p vicwell 29-02-2024 3 1 Download
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Immunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate into a wide array of neoepitopes; however, a systematic classifcation of the neoantigen repertoire in MMRd CRC is lacking.
17p vicwell 29-02-2024 4 1 Download
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The aim of this study is reach for better resolution and differentiation of strains and species within the B. subtilis species and to determine whether MLSA scheme show advantages in 16S rRNA gene-based studies.
12p vibego 02-02-2024 3 0 Download
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This paper has proposed a method of designing Polar codes by determining a synthetic channels reliability index sequence based on the Polarization Weights (PW) method called the Improved Polarization Weights (IPW) method. The simulation results show that the error correction performance of the code designed according to IPW is better than the code structure selected for 5G NR and designed according to the original PW method.
16p vigojek 02-02-2024 1 0 Download
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To investigate the prevalence and spectrum of BRCA1 and BRCA2 mutations in Chinese Hakka patients with breast and ovarian cancer. Methods: A total of 1,664 breast or ovarian cancer patients were enrolled for genetic testing at our hospital. Germline mutations of the BRCA gene were analysed by next-generation sequencing, including the coding regions and exon intron boundary regions.
14p vimichaelfaraday 28-12-2023 8 3 Download
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Ebook "Regulatory RNAs: Basics, methods and applications" is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.
549p lucchinguyen 28-12-2023 8 2 Download
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We aimed to describe the behavior among Chinese ovarian cancer patients with RAD51D germline mutations at our institution. Methods: Next-generation sequencing (NGS) was conducted for the entire coding regions and exon/intron boundaries of the RAD51D genes in 781 Chinese ovarian cancer patients treated at our institution from January 1, 2015 to August 1, 2021.
8p vileonardodavinci 23-12-2023 3 2 Download
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Liver cirrhosis is a well-known risk factor for hepatocellular carcinoma (HCC). However, some HCC cases can also originate from non-cirrhotic livers. The aim of this study was to identify key circular RNAs (circRNAs) associated with the tumorigenesis of non-cirrhotic liver disease.
15p vileonardodavinci 23-12-2023 7 5 Download