Comparative genomic analysis
-
The genetic and immunological factors that contribute to differences in susceptibility and progression between sub-types of inflammatory and autoimmune diseases continue to be elucidated. Inflammatory bowel disease and juvenile idiopathic arthritis are both clinically heterogeneous and known to be due in part to abnormal regulation of gene activity in diverse immune cell types.
16p vibransone 28-03-2024 2 2 Download
-
Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analysis of the roles of T cell immunity in humans by comparing before and after gene correction.
14p vibransone 28-03-2024 5 2 Download
-
The 2015 American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) guidelines for clinical sequence variant interpretation state that “well-established” functional studies can be used as evidence in variant classification.
19p vibransone 28-03-2024 3 1 Download
-
A key step in cancer genome analysis is the identification of somatic mutations in the tumor. This is typically done by comparing the genome of the tumor to the reference genome sequence derived from a normal tissue taken from the same donor.
18p vioraclene 31-03-2024 2 1 Download
-
Klebsiella pneumoniae (Kp) Gram-negative bacteria cause nosocomial infections and rapidly acquire antimicrobial resistance (AMR), which makes it a global threat to human health. It also has a comparatively rare hypervirulent phenotype that can lead to severe disease in otherwise healthy individuals.
12p vicwell 29-02-2024 4 1 Download
-
The objective of this study was to analyze the features of FtsZ proteins in the Bacillus and Lactococcus genus groups. By exploring the available genomes, we identified and characterized FtsZ proteins in 19 Bacillus and 22 Lactococcus species.
12p vigojek 02-02-2024 4 0 Download
-
Ebook "Root genomics" examines how various new genomic technologies are rapidly being applied to the study of roots, including high-throughput sequencing and genotyping, TILLING, transcription factor analysis, comparative genomics, gene discovery and transcriptional profiling, post-transcriptional events regulating microRNAs, proteome profiling and the use of molecular markers such as SSRs, DArTs, and SNPs for QTL analyses and the identification of superior genes/alleles.
328p tachieuhoa 28-01-2024 5 2 Download
-
Part 1 book "Sturkie's avian physiology" includes content: The importance of avian physiology; avian genomics; transcriptomic analysis of physiological systems; avian proteomics; avian metabolomics; mitochondrial physiology—sturkie's book chapter; evolution of birds; domestication of poultry; the avian somatosensory system - a comparative view; avian vision; avian hearing; chemesthesis and olfaction; taste in birds; avian nociception and pain,... and other contents.
791p muasambanhan03 02-01-2024 9 2 Download
-
Endometrial carcinoma (EC) is one of the most common gynecological malignancies in China and globally, accounting for the fourth-prevalent cancer in women. Although numerous studies have confirmed prognostic value of The Cancer Genome Atlas (TCGA) molecular subgroups, it is unclear how they are combined with histological features.
13p vischultz 20-10-2023 5 2 Download
-
In this paper, we present the results of sequencing, analysis and comparison of changes in the genome betweenthe attenuated virus strain Hanvet1.vn and the original pathogenic strain 02HY in order to evaluate the genetic changes related to the virulence and immunogenicity of the vaccine.
8p vimulcahy 18-09-2023 4 3 Download
-
Part 1 book "Equine genomics" includes content: Defining the equine genome - The nuclear genome and the mitochondrial genome, genetic linkage maps, physical and comparative maps, the Y-chromosome, unexpected structural features of the equine major histocompatibility complex, assembly and analysis of the equine genome sequence, genomic tools and resources - Development and applications of an equine SNP genotyping array, functional genomics, coat color genomics.
167p oursky04 14-09-2023 4 2 Download
-
Striped catfish or Vietnamese catfish mainly contributes to national aquaculture exports. However, bacterial diseases result in the decrease of striped catfish production efficiency and the most popular disease is hemorrhagic septicemia caused by Aeromonas hydrophila. Bacteriophages or bacterial viruses have been investigated as alternative biological agents to control pathogenic bacterial infections in aquaculture for many decades.
17p vicaptainmarvel 21-04-2023 6 2 Download
-
Although copy number variation (CNV) has received much attention, knowledge about the characteristics of CNVs such as occurrence rate and distribution in the genome between populations and within the same population is still insufficient.
8p vinarcissa 21-03-2023 5 1 Download
-
Head spot is one of the phenotypes identified in the KFRS4/Kyo rat strain. Although previous linkage analysis suggested that Ednrb, which is frequently involved in coat color variations in various animals, could be the gene responsible for this phenotype, no mutations have been identified in its coding region.
8p vinarcissa 21-03-2023 3 1 Download
-
Grain zinc and iron concentration is a complex trait that is controlled by quantitative trait loci (QTL) and is important for maintaining body health. Despite the substantial effort that has been put into identifying QTL for grain zinc and iron concentration, the integration of independent QTL is useful for understanding the genetic foundation of traits.
15p vinarcissa 21-03-2023 4 1 Download
-
The Poaceae family is of great importance to human beings since it comprises the cereal grasses which are the main sources for human food and animal feed. With the rapid growth of genomic data from Poaceae members, comparative genomics becomes a convinent method to study genetics of diffierent species.
8p vinarcissa 21-03-2023 7 1 Download
-
Two genetic marker-based methods are compared for use in breed prediction, using a New Zealand sheep resource. The methods were a genomic selection (GS) method, using genomic BLUP, and a regression method (Regp) using the allele frequencies estimated from a subset of purebred animals.
15p vinarcissa 21-03-2023 3 1 Download
-
MYB family proteins are one of the most abundant transcription factors in the cotton plant and play diverse roles in cotton growth and evolution. Previously, few studies have been conducted in upland cotton, Gossypium hirsutum. The recent release of the G. hirsutum genome sequence provides a great opportunity to identify and characterize the entire upland cotton MYB protein family.
12p vinarcissa 21-03-2023 2 1 Download
-
Feed intake plays an important economic role in beef cattle, and is related with feed efficiency, weight gain and carcass traits. However, the phenotypes collected for dry matter intake and feed efficiency are scarce when compared with other measures such as weight gain and carcass traits.
8p vinarcissa 21-03-2023 3 1 Download
-
The Nordic Red Cattle (NRC) consists of animls belonging to the Danish Red, Finnish Ayrshire, and Swedish Red breeds. Compared to the Holstein breed, NRC animals are smaller, have a shorter calving interval, lower mastitis incidence and lower rates of stillborn calves, however they produce less milk, fat and protein.
11p vinarcissa 21-03-2023 2 1 Download