Complex workflow

To diagnose the full spectrum of hereditary and congenital diseases, genetic laboratories use many different workfows, ranging from karyotyping to exome sequencing. A single generic high-throughput workflow would greatly increase efciency. We assessed whether genome sequencing (GS) can replace these existing workflows aimed at germline genetic diagnosis for rare disease.

11p vicwell 29-02-2024 4 2   Download

Bioinformatics publications typically include complex software workflows that are difficult to describe in a manuscript. We describe and demonstrate the use of interactive software notebooks to document and distribute bioinformatics research.

9p visteverogers 24-06-2023 8 2   Download

As clinical trials evolve in complexity, clinical trial data models that can capture relevant trial data in meaningful, structured annotations and computable forms are needed to support accrual.

10p vighostrider 25-05-2023 7 2   Download

The increasing complexity of data streams and computational processes in modern clinical health information systems makes reproducibility challenging. Clinical natural language processing (NLP) pipelines are routinely leveraged for the secondary use of data. Workflow management systems (WMS) have been widely used in bioinformatics to handle the reproducibility bottleneck.

12p vighostrider 25-05-2023 2 2   Download

Our study documented communication workflows across adult day care centers (ADCs) and primary care providers (PCPs) around complex needs of persons living with dementia (PLWD). We also identified barriers and facilitators to productive communication in clinical decision support and clinical information systems.

9p vighostrider 25-05-2023 7 2   Download

High-throughput sequencing (HTS) technologies are increasingly applied to analyse complex microbial ecosystems by mRNA sequencing of whole communities, also known as metatranscriptome sequencing. This approach is at the moment largely limited to prokaryotic communities and communities of few eukaryotic species with sequenced genomes. For eukaryotes the analysis is hindered mainly by a low and fragmented coverage of the reference databases to infer the community composition, but also by lack of automated workflows for the task.

17p vilarryellison 29-10-2021 11 1   Download

A common class of biomedical analysis is to explore expression data from high throughput experiments for the purpose of uncovering functional relationships that can lead to a hypothesis about mechanisms of a disease. We call this analysis expression driven, −omics hypothesizing.

12p vikentucky2711 26-11-2020 7 0   Download

Gene and protein interaction experiments provide unique opportunities to study the molecular wiring of a cell. Integrating high-throughput functional genomics data with this information can help identifying networks associated with complex diseases and phenotypes.

22p vikentucky2711 24-11-2020 18 3   Download

Reproducibility is one of the tenets of the scientific method. Scientific experiments often comprise complex data flows, selection of adequate parameters, and analysis and visualization of intermediate and end results.

12p vioklahoma2711 19-11-2020 9 2   Download

There has been an enormous expansion of use of chromatin immunoprecipitation followed by sequencing (ChIP-seq) technologies. Analysis of large-scale ChIP-seq datasets involves a complex series of steps and production of several specialized graphical outputs.

13p vioklahoma2711 19-11-2020 15 1   Download

Genotyping-by-sequencing (GBS), a method to identify genetic variants and quickly genotype samples, reduces genome complexity by using restriction enzymes to divide the genome into fragments whose ends are sequenced on short-read sequencing platforms.

12p viconnecticut2711 29-10-2020 9 2   Download

The consensus emerging from the study of microbiomes is that they are far more complex than previously thought, requiring better assemblies and increasingly deeper sequencing. However, current metagenomic assembly techniques regularly fail to incorporate all.

8p viconnecticut2711 28-10-2020 17 1   Download

Metagenomics caused a quantum leap in microbial ecology. However, the inherent size and complexity of metagenomic data limit its interpretation. The quantification of metagenomic traits in metagenomic analysis workflows has the potential to improve the exploitation of metagenomic data.

13p vicolorado2711 23-10-2020 13 3   Download

Handicraft production has complexity in its product, as well as manufacturing processes. Especially in case of Small and Medium Enterprises (SMEs), the production characteristics are chaotic and hard to control. Several problems can be pointed out, e.g. line unbalance, excessive stock, improper work assignment, ambiguous workflow,… Such a production system with these flaws incorporated cannot be reliable and effective. However; in Vietnam, this situation is common due to the small size of business operation, large number of workers, and cheap price for labour hour.

7p quenchua5 14-05-2020 32 1   Download

Surface View a topic Four Point Surface From Point Cloud Sheets From Curves Ribbon Builder Bounded Plane Midsurface Transition Patch Openings Through Points and From Poles 1. Four Point Surface Use the Four Point Surface command to create a surface by specifying four points. This is useful for creating base surfaces that support the surface based Class-A workflow. You can easily modify such a surface by increasing the degree and patch into a more complex surface with the desired shape. You must follow these point specifying conditions:...

37p allspackht 13-06-2013 66 12   Download

Metadata associated with each document indicate its status in the process, and it changes as each task is completed: first draft, edited, final draft, translated, published. In this example the sequence of tasks is linear, even if the document edited must be revised by the Author before going to the next step. Workflow processes can be more complex; for example, they can include parallel flows, multiple feedback or control loops.

16p hoangyen999 05-05-2013 48 1   Download

Autodesk Robot™ Structural Analysis Professional software is a collaborative, versatile, and faster software application that can help you compete and win in the global economy. Purpose-built for BIM, Autodesk Robot Structural Analysis Professional calculates even your more complex models with powerful finite element auto-meshing, nonlinear algorithms, and a comprehensive collection of design codes to help you achieve results in minutes, not hours.

6p nguyennam129 23-03-2013 188 32   Download

Designed for video-production professionals, Final Cut Server sets the standard for intuitive media asset management, making it easy to manage large collections of media files efficiently. In this Apple-authorized reference guide, system integrator Drew Tucker takes you on a comprehensive tour of the software, covering everything from tools for tracking, reviewing, and approving jobs to automating complex sequences of tasks in a busy post environment. Along the way, Tucker shares essential workflows that will shave hours from your post-production jobs....

125p ken333 07-06-2012 88 11   Download

Part IV Getting Art Out of Illustrator Clicking the little camera icon in the upper left of the panel allows you to capture a data set. Data sets are stored in Illustrator as XML data, and you can both import and export variables and data sets from the Variables panel menu. Because XML is a standard format, Illustrator can very easily integrate into complex workflows and back-end systems. Understanding scripting A script is a list of commands that are contained in a single file. When you run a script, your computer follows the commands that are contained within the script.

83p myngoc8 15-10-2011 47 4   Download

If there’s one thing I’ve learned as a developer, it’s this: complexity happens; simplicity, you have to strive for. Nowhere is this truer than in education. Our role as teachers, by definition, is to simplify subjects so that they can be easily understood. A good teacher dispels trepidation with anecdote, abstraction with analogy, superstition and magic with knowledge.

640p vcongpham 21-06-2009 415 136   Download