Concerted mechanism

Biological processes are controlled by groups of genes acting in concert. Investigating gene–gene interactions within different cell types can help researchers understand the regulatory mechanisms behind human complex diseases, such as tumors.

18p vicwell 29-02-2024 3 1   Download

Continued part 1, part 2 of ebook "Advanced organic chemistry - Part A: Structure and Mechanisms" has presents the following content: addition, condensation and substitution reactions of carbonyl compounds; aromaticity; aromatic substitution; concerted pericyclic reactions; free radical reactions; photochemistry; structure-reactivity relationships in hydrogen abstraction reactions;...

566p dieptieuung 19-07-2023 5 2   Download

This study demonstrated the kinetics of nucleophilic substitution reactions of butyl methyl chlorophosphate (2) with X-anilines (XC6H4NH2) and deuterated X-anilines (XC6H4ND2) in MeCN at 55.0 ± 0.1°C together with the general optimized method for the synthesis of 2 under mild conditions. Different spectroscopic characterizations revealed the formation of 2 with high purity. The free energy relationship with the substituents X in the anilines exhibited biphasic concavity upwards with a break point at X = H, which induced large negative ρX and small positive βX values.

16p tudichquannguyet 29-11-2021 8 1   Download

The mechanism as well the stereochemistry of cascade cycloisomerization of 15–membered triazatriacetylenic macrocycle was investigated theoretically by using M062X/6–31+G(d,p) and M062X/LANL2DZ calculations. The results showed that the mechanism and outcome of the reaction depended on the absence and presence of a transition metal catalyst. So that, in thermal-induced condition, the reaction had to experience several suprafacial concerted reactions including Ene-reaction (DG# =35.38 kcal/mol), Diels–Alder cycloaddition (DG# = 17.16 kcal/mol), and sigmatropic H-shift rearrangement (DG# = 56.

16p tudichquannguyet 29-11-2021 6 1   Download

Sparse principal component analysis (PCA) is a popular tool for dimensionality reduction, pattern recognition, and visualization of high dimensional data. It has been recognized that complex biological mechanisms occur through concerted relationships of multiple genes working in networks that are often represented by graphs.

12p viflorida2711 30-10-2020 19 3   Download

Reproductive characteristics are well-established risk factors for breast cancer, but the underlying mechanisms are not fully resolved. We hypothesized that altered DNA methylation, measured in tumor tissue, could act in concert with reproductive factors to impact breast carcinogenesis.

9p vikuala271 13-06-2020 8 1   Download

Pongamia (Millettia pinnata syn. Pongamia pinnata), an oilseed legume species, is emerging as potential feedstock for sustainable biodiesel production. Breeding Pongamia for favorable traits in commercial application will rely on a comprehensive understanding of molecular mechanism regulating oil accumulation during its seed development.

16p vichoji2711 29-04-2020 13 1   Download

(bq) part 2 book "advanced organic chemistry (part a: structure and mechanisms)" has contents: carbanions and other carbon nucleophiles, addition; condensation and substitution reactions of carbonyl compounds; aromaticity; aromatic substitution; concerted pericyclic reactions; free radical reactions; photochemistry.

616p bautroibinhyen20 06-03-2017 67 7   Download

The spirit of the DIT community of academic and non-academic members of staff is something which defines the Institute and has been key to its successful development throughout its history. Circa 2,500 people are employed in DIT in many different roles. Although currently dispersed across so many locations around the city, there has been a concerted effort to develop a ‘One DIT’ approach to delivery of teaching and support to students.

13p docvachiase 03-05-2013 56 7   Download

Although the role of arachidonic acid (AA) in the regulation of steroidogenesis is well documented, the mechanism for AArelease isnot clear.Therefore, theaimof this studywas to characterize the role of an acyl-CoA thioesterase (ARTISt) and an acyl-CoA synthetase as members of an alternative pathway in the regulation of the intracellular levels of AA in steroidogenesis. Purified recombinant ARTISt releases AA from arachidonoyl-CoA (AA-CoA) with a Kmof 2lM.

9p tumor12 22-04-2013 36 2   Download

The appropriate government may also constitute a State Commission for the Protection of Child Rights (SCPCR), to carry out these functions. It is important to note that several challenges related to infrastructure, capacities, mass information and awareness, teacher availability, training functional redressal mechanisms, and effective monitoring system will need to be addressed in a concerted manner to render these commitments effectively and ensure the realisation of the right of children in the age-group 6-14 years to free and compulsory education.

194p nhamnhiqa 01-03-2013 43 2   Download

No one of the mechanical processes carried on by the use of a given outfit of appliances is independent of other processes going on elsewhere. Each draws upon and presupposes the proper working of many other processes of a similarly mechanical character. None of the processes in the mechanical industries is self−sufficing. Each follows some and precedes other processes in an endless sequence, into which each fits and to the requirements of which each must adapt its own working. The whole concert of industrial operations is to be taken as a machine process, made up...

48p bi_ve_sau 05-02-2013 47 5   Download

Infection with HPV is highly prevalent among gay and bisexual men. This population also has a high incidence of HPV-associated anal lesions and cancer. Gay and bisexual men living with HIV have an even higher inci- dence and progression of disease. This is similar to the story for cervical cancer. However, with strong advocacy and a concerted effort by researchers, clinicians, and public health leaders, dramatic reductions in the incidence of cervical cancer have been achieved.

6p taisaokhongthedung 09-01-2013 54 2   Download

now is the time for all partners to join forces in a concerted effort. this means scaling up and prioritizing a package of high-impact interventions, strengthening health systems, and integrating efforts across diseases and sectors such as health, education, water, sanitation and nutrition. It also means promoting human rights, gender equality and poverty reduction. all actors should work to optimize current investments.

16p connhobinh 10-12-2012 42 0   Download

Automation is the use of control systems (such as numerical control, programmable logic control, and other industrial control systems), in concert with other applications of information technology (such as computer-aided technologies [CAD, CAM, CAx]), to control industrial machinery and processes, reducing the need for human intervention. In the scope of industrialization, automation is a step beyond mechanization.

360p 123859674 30-06-2012 113 38   Download