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Confounder correction
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Nuclease-based technologies have been developed that enable targeting of specific DNA sequences directly in the zygote. These approaches provide an opportunity to modify the genomes of inbred mice, and allow the removal of strain-specific mutations that confound phenotypic assessment.
12p
vioraclene
31-03-2024
4
2
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To define confounding bias in difference-in-difference studies and compare regression- and matching-based estimators designed to correct bias due to observed confounders. This causal model will then guide the specification of an appropriate analytical model (eg, using regression or matching) that can produce unbiased treatment effect estimates. We emphasize the importance of thoughtful incorporation of covariates to address confounding bias in difference-in-difference studies.
10p
vigamora
25-05-2023
5
2
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Hyponatremia associated with a low serum osmolality is a common and confounding electrolyte disorder. Correcting hyponatremia is also complicated, especially in the setting of chronic hyponatremia. Here, we provide a rational approach to accurately detecting and safely treating acute on chronic euvolemic hyponatremia in the setting of acute polydipsia with a chronic reset osmostat.
6p
videadpool
05-05-2023
5
2
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Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the efficient discovery of cancer cell vulnerabilities. While several studies have focused on correcting for DNA cleavage toxicity biases associated with copy number alterations, the effects of sgRNAs co-targeting multiple genomic loci in CRISPR screens have not been discussed.
25p
vigalileogalilei
27-02-2022
16
1
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Based on an extensive simulation study, McGregor and colleagues recently recommended the use of surrogate variable analysis (SVA) to control for the confounding effects of cell-type heterogeneity in DNA methylation association studies in scenarios where no cell-type proportions are available.
3p
vialfrednobel
29-01-2022
9
0
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Expression quantitative trait loci (eQTL) mapping is a widely used tool to study the genetics of gene expression. Confounding factors and the burden of multiple testing limit the ability to map distal trans eQTLs, which is important to understand downstream genetic effects on genes and pathways.
13p
viaristotle
29-01-2022
12
0
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One challenge facing omics association studies is the loss of statistical power when adjusting for confounders and multiple testing. The traditional statistical procedure involves fitting a confounder-adjusted regression model for each omics feature, followed by multiple testing correction.
18p
viarchimedes
26-01-2022
11
0
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Population structure among study subjects may confound genetic association studies, and lack of proper correction can lead to spurious findings. The Genotype-Tissue Expression (GTEx) project largely contains individuals of European ancestry, but the v8 release also includes up to 15% of individuals of non-European ancestry.
20p
viarchimedes
26-01-2022
6
0
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This compositional bias confounds inference of absolute abundances. Commonly used count data normalization approaches like library size scaling/rarefaction/subsampling cannot correct for compositional or any other relevant technical bias that is uncorrelated with library size.
23p
vitzuyu2711
29-09-2021
8
1
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Genome editing by CRISPR-Cas9 technology allows large-scale screening of gene essentiality in cancer. A confounding factor when interpreting CRISPR-Cas9 screens is the high false-positive rate in detecting essential genes within copy number amplified regions of the genome.
16p
vitzuyu2711
29-09-2021
11
1
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Systematic technical effects-also called batch effects-are a considerable challenge when analyzing DNA methylation (DNAm) microarray data, because they can lead to false results when confounded with the variable of interest.
15p
vicolorado2711
22-10-2020
9
0
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Always controversial, Thomas DeGregori has released another classic volume that is sure to inform, confound, and present new perspectives on todays environmental issues. This time he is taking on the environmentalists, naturalists, green consumerists, and those that hail the natural lifestyle as the healthy, politically correct thing to do. DeGregori examines the economics of green consumerism, the reality of saving the environment, how historical cultures may have influenced environmental damage, and how being ecologically correct may have a more damaging effect on our environment....
253p
huetay_1
28-02-2013
87
18
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