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Contiguous genes
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Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome. In vitro studies in the laboratory have revealed their important role in parasite fitness phenotypes such as red cell invasion, transmissibility and cytoadherence. Studies of natural parasite populations indicate that CNVs are also common in the field and thus may facilitate adaptation of the parasite to its local environment.
15p
vibeauty
23-10-2021
10
0
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Natural and artificial selection leads to changes in certain regions of the genome resulting in selection signatures that can reveal genes associated with the selected traits. Selection signatures may be identified using different methodologies, of which some are based on detecting contiguous sequences of homozygous identical-bydescent haplotypes, called runs of homozygosity (ROH), or estimating fixation index (FST) of genomic windows that indicates genetic differentiation.
20p
visilicon2711
20-08-2021
8
1
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Brassica nigra (BB), also called black mustard, is grown as a condiment crop in India. B. nigra represents the B genome of U’s triangle and is one of the progenitor species of B. juncea (AABB), an important oilseed crop of the Indian subcontinent. We report the genome assembly of B. nigra variety Sangam.
12p
vilichoo2711
25-06-2021
11
1
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In chapter 7 we will explore one strategy bacteria employ to control the expression of their genes: by grouping functionally related genes together so they can be regulated together easily. Such a group of contiguous, coordinately controlled genes is called an operon.
49p
tangtuy05
30-03-2016
56
2
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Chapter 7 - Operons: Fine control of bacterial transcription. In this chapter we will explore one strategy bacteria employ to control the expression of their genes: by grouping functionally related genes together so they can be regulated together easily. Such a group of contiguous, coordinately controlled genes is called an operon.
47p
tangtuy02
08-03-2016
57
2
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HIC1(hypermethylated in cancer) is a tumour suppressor gene located in 17p13.3, a region frequently hypermethylated or deleted in many types of prevalent human tumour.HIC1is also a candidate for a contiguous-gene syndrome, the Miller–Dieker syndrome, a severe form of lissencephaly accompanied by developmental anomalies.
12p
inspiron33
25-03-2013
33
2
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Microdeletion Syndromes The term contiguous gene syndrome refers to genetic disorders that mimic a combination of single-gene disorders. They result from the deletion of a small number of tightly clustered genes. Because some are too small to be detected cytogenetically, they are termed microdeletions. The application of molecular techniques has led to the identification of at least 18 of these microdeletion syndromes (Table 63-4). Some of the more common ones include the Wilms' tumor–aniridia complex (WAGR), Miller Dieker syndrome (MDS), and velocardiofacial (VCF) syndrome.
5p
konheokonmummim
03-12-2010
72
2
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