
Controversially
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aIIbb3, a member of the integrin family of adhesive protein receptors, is the most abundant glycoprotein on platelet plasma-membranes and binds to adhesive proteins via the recognition of short amino acid sequences, for example the ubiquitous RGD motif.However, elucidation of the ligand-binding domains of the receptor remains controversial, mainly owing to the fact that integrins are conformationally labile during purification and storage.
8p
tumor12
20-04-2013
49
3
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The intracellular role of placental protein 17b (PP17b)/ TIP47has been controversial, because it is considered tobe a protein required for mannose 6-phosphate receptor trans-port from endosome totrans-Golgi as well as a neutral lipid droplet-associatedprotein.The similaritybetween theamino acid sequences of PP17 variants, adipophilin and perilipins, andbetween their gene structures indicate that PP17baswell as other alternatively spliced PP17 variants belong to the lipid storage droplet protein family, containing also some differentiation factors....
13p
tumor12
20-04-2013
44
3
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White and brown adipocytes are usually located in distinct depots; however, in response to cold, brown adipocytes appear in white fat. This response is mediated by b-adrenoceptors but there is a controversy about the sub-type(s) involved. In the present study, we exposed to cold b3 -adrenoceptor knockout mice (b3KO) on a C57BL/6J geneticbackgroundandmeasured inwhiteadipose tissue the density of multilocular cells and the expression of the brown adipocyte marker uncoupling protein-1 (UCP1).
7p
tumor12
20-04-2013
37
4
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Although belonging to the widely investigated peroxidase superfamily, lactoperoxidase (LPO) and myeloperoxidase (MPO) share structural and functional features that make them peculiar with respect to other enzymes of the same group. A survey of the available literature on their catalytic intermediates enabled us to ask some questions that remained unanswered. These questions concern controver-sial features of theLPOandMPOcatalytic cycle, suchas the existence of Compound I and Compound II isomers and the identification of their spectroscopic properties....
10p
fptmusic
12-04-2013
41
2
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Although highly controversial just a few years ago, the idea that G-pro-tein-coupled receptors (GPCRs) may undergo homo-oligomerization or hetero-oligomerization has recently gained considerable attention. The recognition that GPCRs may exhibit either dimeric or oligomeric structures is based on a number of different biochemical and biophysical approaches.
8p
fptmusic
11-04-2013
54
2
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There is still a controversy over the mechanism of promoter DNA strand separation upon open transcription complex (RPo) formation by Escheri-chia coli RNA polymerase: is it a single or a stepwise process controlled by Mg 2+ ions and temperature? To resolve this question, the kinetics of pseudo-first-order oxidation of thymine residues by KMnO4 in the )11…+2 DNA region of RPo at thekPRpromoter was examined under single-hit conditions as a function of temperature (13–37C) in the absence or presence of 10 mmMgCl2....
16p
awards
06-04-2013
50
2
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Malonyl-CoA, a potent inhibitor of carnitine pamitoyl transferase-I (CPT-I), plays a pivotal role in fuel selection in cardiac muscle. Malonyl-CoA decarboxylase (MCD) cata-lyzes the degradation of malonyl-CoA, removes a potent allosteric inhibition on CPT-I and thereby increases fatty acid oxidation in the heart. Although MCDhas several Ser/ Thr phosphorylation sites, whether it is regulated by AMP-activated protein kinase (AMPK) has been controversial. We therefore overexpressed MCD(Ad.MCD) and consti-tutively active AMPK (Ad.
10p
dell39
03-04-2013
41
3
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The molecular chaperone Grp94 (gp96) of the endoplasmic reticulum (ER) lumen plays an essential role in the structural maturation and⁄or secretion of proteins destined for transport to the cell surface. Its proposed role in binding and transferring peptides for immune recognition is, however, controversial.
10p
dell39
27-03-2013
43
3
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The biochemical nature and the replication of infectious prions have been intensively studied in recent years. Much less is known about the cellular events underlying neuronal dysfunction and cell death. As the cellular func-tion of the normal cellular isoform of prion protein is not exactly known, the impact of gain of toxic function or loss of function, or a combination of both, in prion pathology is still controversial.
6p
galaxyss3
21-03-2013
63
5
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The structure of human telomeric DNA is controversial; it depends upon the sequence contexts and the methodologies used to determine it. The solution structure in the presence of K + is particularly interesting, but the structure is yet to be elucidated, due to possible conformational heterogen-eity.
12p
galaxyss3
19-03-2013
39
3
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We investigated the soluble forms of the earliest activation antigen of human leukocyte CD69. This receptor is expressed at the cell surface as a type II homodimeric membrane protein. However, the elements necessary to prepare the soluble recombinant CD69 suitable for structural studies are a matter of controversy.
18p
vinaphone15
28-02-2013
39
3
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Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of tumour cells, but not in most normal cells, and has attracted considerable attention for its potential use in cancer therapy. Recently, increasing evidence has shown that TRAIL is involved in inflam-mation, although much of this evidence is controversial.
13p
vinaphone15
27-02-2013
37
2
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PLANNING AN INTERNATIONAL AUDIT: AN EMPIRICAL INVESTIGATION OF INTERNAL AUDITOR JUDGEMENT With nearly as long a pedigree is the idea that these family background effects may operate above the individual level. The school-level association between average student background and average performance is typically much stronger than is the same association at the individual level.
247p
mualan_mualan
25-02-2013
73
10
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In many laboratories, the requirement of microtubule-associated proteins (MAPs) and the stabilization of microtubules for the elongation of neurites has been intensively investigated, with controversial results being obtained. We have observed that the neurite microtubules of Cath.a-differentiated (CAD) cells, a mouse brain derived cell, are highly dynamic structures, and so we analyzed several aspects of the cytoskeleton to investigate the molecu-lar causes of this phenomenon.
14p
vinaphone15
25-02-2013
46
4
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could resolve the controversies
9p
panasonic02
15-12-2011
63
4
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Many drugs have unknown, controversial or multiple mechanisms of action. Four recent ‘chemical genomic’ studies, using genome-scale collections of yeast gene deletions that were either arrayed or barcoded, have presented complementary approaches to identifying gene-drug and pathwaydrug interactions. deposited research The fact that much of modern drug research is target-oriented obscures the long history during which the effects of drugs were discovered prior to identification of their targets. There remain many...
4p
thulanh19
09-11-2011
58
5
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Bằng chứng sẵn có phù hợp với quan sát các nhà quản lý tin Các cổ đông muốn có một tiến triển đều đặn cổ tức. Đối với các nhà quản lý của rủi ro công ty có thu nhập dao động lớn
10p
nhungngaytuoidep
06-11-2011
37
7
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Etomidate and adrenal insufficiency: the controversy continues...
2p
thulanh18
05-11-2011
35
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Selection of patients with severe pelvic fracture for early angiography remains controversial
6p
toshiba18
31-10-2011
58
2
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Penetrating abdominal injuries: management controversies
7p
toshiba18
31-10-2011
33
2
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