Core materials on drug release

This work was envisaged to develop compression-coated tablets using a blend of Ca+2 ion crosslinked carboxymethyl xanthan gum (CMXG) and sodium alginate (SAL) for delayed release of immediate pulse release tablets of prednisolone (PDL) in the colon without the need of colonic bacterial intervention for degradation of the polysaccharide coat. The core tablets containing PDL and other compatible excipients were prepared by direct compression method and subsequently compression coated with different ratios of CMXG and SAL.

12p caothientrangnguyen 09-05-2020 18 0   Download