Core residues
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Ebook "Electron density and chemical bonding II: Theoretical charge density studies" focuses on state-of-the-art, theoretically oriented advancements in the field and offers six very different, yet important contributions. In the first chapter, Koritsanszky and coworkers revisit the pseudoatom model, which together with the maximum entropy method constitutes the core of the discipline.
300p coduathanh1122 27-03-2024 6 1 Download
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This test method covers dc ballistic testing for the determination of basic magnetic properties of materials in the form of ring, toroidal, link, double-lapped Epstein cores, or other standard shapes which may be cut, stamped, machined, or ground from cast, compacted, sintered, forged, or rolled materials. It includes tests for normal induction and hysteresis taken under conditions of steep wavefront reversals of the direct-current magnetic field strength.
8p hth_hn_vn 10-12-2023 10 4 Download
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Histone deacetylases (HDACs) are the proteins responsible for removing the acetyl group from lysine residues of core histones in chromosomes, a crucial component of gene regulation. Eleven known HDACs exist in humans and most other vertebrates. While the basic function of HDACs has been well characterized and new discoveries are still being made, the transcriptional regulation of their corresponding genes is still poorly understood.
12p visilicon2711 20-08-2021 6 1 Download
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Distinguishing biologically relevant interfaces from lattice contacts in protein crystals is a fundamental problem in structural biology. Despite efforts towards the computational prediction of interface character, many issues are still unresolved.
16p viwyoming2711 16-12-2020 11 1 Download
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Residues in a protein might be buried inside or exposed to the solvent surrounding the protein. The buried residues usually form hydrophobic cores to maintain the structural integrity of proteins while the exposed residues are tightly related to protein functions.
11p vioklahoma2711 19-11-2020 9 1 Download
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This reutilization option is a potential candidate technique to make better use of the nuclear resources. Standard two step method is used to calculate node i.e. fuel assembly average burnup and then pin by pin h values are reconstructed to ascertain the residual reactivity in the used fuel pins. Fuel pins with h >1:0 are used to reconstruct to-be-reused fuel assemblies.
11p minhxaminhyeu3 12-06-2019 10 0 Download
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Selenoprotein P (SeP) is a plasma protein that contains up to 10 selenocysteine residues and accounts for about 50% of total selenium in human plasma. We have previously shown that SeP expression in the human liver cell line HepG2 is inhibited by transforming growth factor (TGF)-b1 on a transcriptional level. Smad proteins are the transcriptional mediators of TGF-b signalling and putative Smad-binding elements (SBE) comprising the core sequence CAGACA are present at two positions in the SeP promoter....
6p system191 01-06-2013 33 3 Download
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Decorin is a small leucine-rich chondroitin/dermatan sulfate proteoglycan reported to interact with ®brillar collagens through its protein core and to localize atdandebands of the collagen ®bril banding pattern. Using a solid-phase assay, we have determined the interaction of peptides derivedbyCNBr cleavage of type I and type II collagenwith decorin extracted from bovine tendon and its protein core and with a recombinant decorin preparation.
10p research12 29-04-2013 34 2 Download
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Defining the various tasks required of GDHit was essential before any visual brainstorming was approached. These tasks, once defined, helped clarify perceptions of layout and functionality. The main function of the timeline is to search content chronologically (span a set number of years), filter content (through the classification of various categories), read content (the most important single function of the timeline) and filter contextually rather than linearly (by filtering content through the Tags).
99p hoangphiyeah1tv 24-04-2013 86 22 Download
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The amino acid glycine is identified as a component of the inner core oligosaccharide in meningococcal lipopolysac-charide (LPS). Ester-linked glycine residues were consis-tently foundbymass spectrometry experiments tobe located on the distal heptose residue (HepII) in LPS from several strainsofNeisseriameningitidis.Nuclearmagnetic resonance studies confirmedand extended this observation locating the glycine residue at the 7-position of theHepIImolecule inL3 and L4 immunotype strains.
7p research12 23-04-2013 39 1 Download
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A sialylated lacto-N-neotetraose (Sial-lNnT) structural unit was identified and structurally characterized in the lipo-polysaccharide (LPS) from the genome-sequenced strain Road (RM118) of the human pathogenHaemophilus influ-enzaegrown in the presence of sialic acid. A combination of molecular genetics, MS and NMR spectroscopy techniques showed that this structural unit extended from the proximal heptose residue of the inner core regionof theLPSmolecule.
11p research12 23-04-2013 34 1 Download
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The interface between thec-subunit oligomer and the asubunit in the F0sector of the ATP synthase is believed to formthe core of the rotatingmotor powered by the protonic ¯ow. Besides the essential cAsp61 and aArg210 residues (Escherichia colinumbering), a few other residues at this interface, although nonessential, show a high degree of conservation, among these aGlu219.
9p research12 23-04-2013 19 1 Download
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The structure of the lipid A and core region of the lipo-polysaccharide (LPS) fromFrancisella tularensis(ATCC 29684) was analysed using NMR, mass spectrometry and chemical methods. The LPS contains a b-GlcN-(1–6)-GlcN lipid A backbone, but has a number of unusual structural features; it apparently has no substituent at O-1 of the reducing end GlcN residue in the lipid part in the major part of the population, no substituents at O-3 and O-4ofb-GlcN, and no substituent at O-4of the Kdo residue.
7p tumor12 22-04-2013 46 2 Download
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Signal sequences often containa-helix-destabilizing amino acids within the hydrophobic core. In the precursor of the Escherichia coliouter-membrane protein PhoE,the glycine residue at position)10 (Gly )10 ) is thought to be responsible for the break in the a-helix. Previously,we showed that substitution of Gly )10 bya-helix-promoting residues (Ala, Cys or Leu) reduced the proton-motive force dependency of the translocation of the precursor,but the actual role of the helix breaker remained obscure. ...
8p tumor12 22-04-2013 31 2 Download
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X-ray crystallography of the nonheme manganese catalase fromLactobacillus plantarum(LPC) [Barynin, V.V., Whit-taker, M.M., Antonyuk, S.V., Lamzin, V.S., Harrison, P.M., Artymiuk, P.J. & Whittaker, J.W. (2001)Structure9, 725–738] has revealed the structure of the dimanganese redox cluster together with its protein environment. The oxidized [Mn(III)Mn(III)] cluster is bridged by two solvent molecules (oxo and hydroxo, respectively) together with a l1,3bridging glutamate carboxylate and is embedded in a web of hydrogen bonds involving an outer sphere tyrosine residue (Tyr42). ...
15p tumor12 20-04-2013 25 4 Download
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Structural analysis of the lipopolysaccharide (LPS) from nontypeableHaemophilus influenzaestrain 981 has been achieved using NMRspectroscopy and ESI-MS on O-deacylatedLPSand core oligosaccharide (OS)material as well as by ESI-MS n on permethylated dephosphorylated OS. A heterogeneous glycoform population was identified, resulting from the variable length of the OS branches attached to the glucose residue in the common structural element of H. influenzae LPS, L-a-D-Hepp-(1fi2)-[PEtnfi6]-L-a-D-Hepp-(1fi3)-[b-D-Glcp-(1fi4)]-L-a-D-Hepp-(1fi5)-[PPEtnfi4]-a-Kdop-(2fi6)-Lipid A....
13p fptmusic 16-04-2013 44 2 Download
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We have isolated and characterized a second [Fe]-hydro-genasegene fromthegreenalga,Chlamydomonas reinhardtii. TheHydA2gene encodes a protein of 505 amino acids that is 74% similar and 68% identical to the known HydA1 hydrogenase fromC. reinhardtii.HydA2 contains all the conserved residues and motifs found in the catalytic core of the family of [Fe]-hydrogenases. We demonstrate that both theHydA1and theHydA2transcripts are expressed upon anaerobic induction, achieved either by neutral gas purging or by sulfur deprivation of the cultures. ...
9p fptmusic 16-04-2013 44 1 Download
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Peptides composed of leucyl and lysyl residues (LK pep-tides) with different compositions and sequences were compared for their antibacterial activities usingcell wall-less bacteria of the classMollicutes(acholeplasmas, mycoplas-mas and spiroplasmas) as targets. The antibacterial activity of the amphipathica-helical peptides varied with their size, 15 residues beingthe optimal length, independent of the membrane hydrophobic core thickness and the amount of cholesterol.
11p fptmusic 16-04-2013 34 1 Download
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The structure of the lipopolysaccharide (LPS) from three Neisseria meningitidisstrains was elucidated. These strains were nonreactive with mAbs that recognize common inner-core epitopes frommeningococcal LPS. It is well established that the inner core of meningococcal LPS consists of a diheptosyl-N-acetylglucosamine unit, in which the distal heptoseunit (Hep II) cancarryPEtnat the 3or 6positionor not at all, and the proximal heptose residue (Hep I) is sub-stituted at the 4 position by a glucose residue. ...
8p fptmusic 16-04-2013 36 2 Download
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Mucin type O-glycosylation is a widespread modification of eukaryotic pro-teins. The transfer of N-acetylgalactosamine to selected serine or threonine residues is catalyzed by a family of polypeptide N-acetylgalactosaminyl-transferases localized in the Golgi apparatus. The most abundant elonga-tion of O-glycans is the addition of a b1-3 linked galactose by the core-1 b1-3 galactosyltransferase (core-1b3GalT), thereby building the T-antigen or core-1 structure Gal(b1-3)GalNAc(a1-O).
11p fptmusic 11-04-2013 28 2 Download