Cox proportional hazards model
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Part 2 of ebook "Regression modeling strategies: With applications to linear models, logistic and ordinal regression, and survival analysis (Second edition)" provides readers with contents including: Chapter 15 - Regression models for continuous Y and case study in ordinal regression; Chapter 16 - Transform-both-sides regression; Chapter 17 - Introduction to survival analysis; Chapter 18 - Parametric survival models; Chapter 19 - Case study in parametric survival modeling and model approximation; Chapter 20 - Cox proportional hazards regression model; Chapter 21 - Case study in cox regressi...
301p daonhiennhien 03-07-2024 2 1 Download
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Cancer survivors have a high risk of mortality, and vitamin D (VD) is associated with the risk of mortality. This study is aim to examine the impact of VD on mortality in cancer survivors.
12p vishanshan 27-06-2024 1 1 Download
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As biomarkers, microRNAs (miRNAs) are closely associated with the occurrence, progression, and prognosis of non-small cell lung cancer (NSCLC). However, the prognostic predictive value of miRNAs in NSCLC has rarely been explored. In this study, the value in prognosis prediction of NSCLC was mined based on data mining models using clinical data and plasma miRNAs biomarkers.
10p vikoch 27-06-2024 1 1 Download
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We propose DEGAS (Diagnostic Evidence GAuge of Single cells), a novel deep transfer learning framework, to transfer disease information from patients to cells. We call such transferrable information “impressions,” which allow individual cells to be associated with disease attributes like diagnosis, prognosis, and response to therapy.
23p viellison 28-03-2024 3 2 Download
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High-sensitivity C-reactive protein (hs-CRP) levels and metabolic syndrome (MetS) are known to be associated with an increased incidence of different cancers. We aimed to evaluate the effect of MetS combined with high hs-CRP levels on the risk of primary liver cancer (PLC).
12p vimichaelfaraday 28-12-2023 6 3 Download
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While PD-L1 expression and neutrophil-to-lymphocyte ratio (NLR) are prognostic biomarkers for lung cancer, few studies have considered their interaction. We hypothesized that the product of PD-L1 expression (tumor proportion score) and the NLR (PD-L1×NLR) might be a postoperative prognostic marker refecting the immune microenvironment of lung cancer.
10p vileonardodavinci 23-12-2023 4 2 Download
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There is limited real-world evidence that describes patients with newly diagnosed multiple myeloma (NDMM) treated with the bortezomib, lenalidomide, and dexamethasone (VRd) triplet regimen. We evaluated patient characteristics and treatment outcomes among nontransplanted NDMM patients who received VRd as their first line of therapy (LOT) in US oncology practice settings.
9p vialfrednobel 23-12-2023 9 5 Download
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No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population.
11p vialfrednobel 23-12-2023 5 4 Download
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Recurrence and metastases are still frequent outcomes after initial tumour control in women diagnosed with breast cancer. Although therapies are selected based on tumour characteristics measured at baseline, prognostic biomarkers can identify those at risk of poor outcomes.
9p vischultz 20-10-2023 4 1 Download
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The current National Comprehensive Cancer Network (NCCN) guidelines recommend that at least 16 lymph nodes should be examined for gastric cancer patients to reduce staging migration. However, there is still debate regarding the optimal management of examined lymph nodes (ELNs) for gastric cancer patients.
11p vioracle 29-09-2023 2 2 Download
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Heart failure (HF) is a severe clinical syndrome caused by diverse etiologies. Classically left ventricle ejection fraction (LVEF) has been used as a diagnostic marker as well as to subdivide HF into 3 groups (HFpEF, HFmEF and HFrEF).
6p vigamora 23-05-2023 3 2 Download
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We collected information on patients with rectal adenocarcinoma in the United States from the Surveillance, Epidemiology, and EndResults (SEER) database. We used this information to establish a model that combined deep learning with a multilayer neural network (the DeepSurv model) for predicting the survival rate of patients with rectal adenocarcinoma.
14p vipriyankagandhi 27-07-2022 7 2 Download
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Although survival based outcomes of lung cancer patients have been well developed, institutional transition of cancer care, that is, when patients transfer from primary visiting hospitals to other hospitals, and mortality have not yet been explored using a large-scale representative population-based sample.
10p viangelamerkel 27-07-2022 1 1 Download
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Adjuvant chemotherapy (ACT) plays an important role in improving the survival of stage II-III colorectal cancer (CRC) patients after curative surgery. However, the prognostic role of irregular delay of ACT (IDacT) for these patients has been less studied.
11p visusanwojcicki 28-06-2022 9 2 Download
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Assessment the impact of disability on mortality among the elderly is vital to healthy ageing. The present study aimed to assess the long-term influence of disability on death in the elderly based on a longitudinal study.
9p vinobelprisen 26-03-2022 13 4 Download
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Diabetes is a major concern for the global health burden. This study aimed to investigate the relationship between handgrip strength (HGS) and the risk of new-onset diabetes and to compare the predictive abilities between relative HGS and dominant HGS.
9p vinobelprisen 26-03-2022 17 5 Download
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Fibrotic hypersensitivity pneumonitis (HP) is a chronic interstitial lung disease caused by allergic responses to repeated exposures to a causative antigen. Therapeutic evidence of the use of corticosteroids to treat fibrotic HP remains lacking, although corticosteroids are recognized as a major treatment option.
12p vimackenziebezos 29-11-2021 4 1 Download
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Diabetes mellitus (DM) is a well-known risk factor for tuberculosis (TB). Metformin, which is an essential anti-diabetic drug, has been shown to exhibit anti-TB efects in patients with DM. Its effect on preventing the development of TB among patients who are newly diagnosed with DM remains unclear.
11p vimackenziebezos 29-11-2021 5 1 Download
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There is evidence that long non-coding RNA (lncRNA) is related to genetic stability. However, the complex biological functions of these lncRNAs are unclear. Multivariate Cox proportional hazard regression analysis was applied to conduct lncRNA prognosis model.
13p vimahuateng 26-11-2021 3 0 Download
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The 21-gene recurrence score (RS) can predict chemotherapy benefit in estrogen receptor-positive, human epidermal growth factor receptor-2-negative (ER+/HER2-) early breast cancer patients. Age would influence the interaction between RS and chemotherapy effect. The current study aimed to determine RS thresholds which were predictive of chemotherapy benefit in young and old women, respectively
10p vimahuateng 26-11-2021 9 1 Download