Cox regression analysis
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Lactate dehydrogenase (LDHs) is an enzyme involved in anaerobic glycolysis, including LDHA, LDHB, LDHC and LDHD. Given the regulatory role in the biological progression of certain tumors, we analyzed the role of LDHs in pan-cancers.
20p vikoch 27-06-2024 1 1 Download
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Tumor-specific growth factor (TSGF) is an immune-related factor that offers good performance in the clinical management of human cancers. However, the role of serum TSGF in esophageal squamous cell carcinoma (ESCC) has not been fully clarified.
8p vileonardodavinci 23-12-2023 4 2 Download
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To investigate the expression and prognostic value of c-Jun in hypopharyngeal squamous cell carcinoma (HPSCC). Methods: A retrospective study was performed on a cohort of 99 HPSCC patients. The expression of c-Jun and phosphorylated-c-Jun (p-c-Jun) was evaluated via immunohistochemistry (IHC) staining. Overall survival (OS) and progression-free survival (PFS) were assessed using Kaplan–Meier method and multivariate Cox regression analysis.
11p vialfrednobel 23-12-2023 5 3 Download
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This study aimed to build a signature on the basis of NRGs to evaluate the prognosis of HCC patients. In this study, using bioinformatic analyses of transcriptome sequencing data of HCC (n=370) from The Cancer Genome Atlas (TCGA) database, 63 differentially expressed NRGs between HCC and adjacent normal tissues were determined. 24 differentially expressed NRGs were found to be related with overall survival (OS).
16p vialfrednobel 23-12-2023 5 3 Download
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Recent studies have shown that deficient mismatch repair (dMMR) rectal cancer may be related to treatment resistance, resulting in a worse prognosis than proficient MMR (pMMR) rectal cancer. The purpose of this study was to explore whether surgery plus other treatments (radiotherapy and chemotherapy) can bring more benefits to these patients than surgery alone.
11p vialfrednobel 23-12-2023 5 3 Download
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The TROIKA trial established that HD201 and trastuzumab were equivalent in terms of primary end-points (total pathological complete response) following neoadjuvant treatment. The objective of the present analysis was to compare survival outcomes and final safety.
9p vischultz 20-10-2023 1 1 Download
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To explore the correlation of tumor necrosis factor-α-induced protein 8-like protein 3 (TIPE3) expressions in colorectal cancer (CRC) with tumor-immune infiltration and patient prognosis.
10p vischultz 20-10-2023 1 1 Download
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SPOCK3 is a secreted extracellular matrix proteoglycan. This study aimed to investigate the effect of SPOCK3 on the malignant progression of prostate cancer and to construct a prognostic model to predict DFS of patients with prostate cancer.
14p vioracle 29-09-2023 5 2 Download
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While depression and anxiety are common mental health issues, only a small segment of the population has access to standard one-on-one treatment. The use of smartphone apps can fill this gap. An app recommender system may help improve user engagement of these apps and eventually symptoms.
8p visteverogers 24-06-2023 3 2 Download
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Ebook Biostatistical methods in epidemiology: Part 2 presents the following chapters: Chapter 7: risk difference methods for closed cohort data, chapter 8: survival analysis, chapter 9: kaplan–meier and actuarial methods for censored survival data, chapter 10: poisson methods for censored survival data, chapter 11: odds ratio methods for case-control data, chapter 12: standardized rates and age–period–cohort analysis, chapter 13: life tables, chapter 14: sample size and power, chapter 15: logistic regression and cox regression.
231p runthenight08 12-04-2023 6 1 Download
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Immune checkpoint inhibitors (ICIs) have been used to successfully treat primary liver cancer (PLC); however, identifying modifiable patient factors associated with therapeutic benefits is challenging.
10p vikolindagrabar 27-07-2022 7 1 Download
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We collected information on patients with rectal adenocarcinoma in the United States from the Surveillance, Epidemiology, and EndResults (SEER) database. We used this information to establish a model that combined deep learning with a multilayer neural network (the DeepSurv model) for predicting the survival rate of patients with rectal adenocarcinoma.
14p vipriyankagandhi 27-07-2022 5 2 Download
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Hepatocellular carcinoma (HCC) is the most common primary liver cancer in the world. Although great advances in HCC diagnosis and treatment have been achieved, due to the complicated mechanisms in tumor development and progression, the prognosis of HCC is still dismal.
17p vipriyankagandhi 27-07-2022 5 1 Download
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Whether pioglitazone may affect breast cancer risk in female diabetes patients is not conclusive and has not been investigated in the Asian populations. This study suggests a null association between pioglitazone and breast cancer risk in female patients with type 2 diabetes mellitus.
11p viangelamerkel 27-07-2022 6 3 Download
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The pattern of opioid use after skeletal trauma is a neglected topic in pain medicine. The purpose of this study was to analyse the long-term prescriptions of potent opioids among patients with tibial shaft fractures.
6p viisaacnewton 26-04-2022 9 1 Download
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Ferroptosis is a newly discovered form of cell death characterized by iron-dependent lipid peroxida‑ tion. This study aims to investigate the potential correlation between ferroptosis and the prognosis of lung adenocar‑ cinoma (LUAD).
14p vimackenziebezos 29-11-2021 10 1 Download
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Ferroptosis is a newly discovered form of cell death characterized by iron-dependent lipid peroxidation. This study aims to investigate the potential correlation between ferroptosis and the prognosis of lung adenocarcinoma (LUAD).
10p vimackenziebezos 29-11-2021 7 0 Download
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There is evidence that long non-coding RNA (lncRNA) is related to genetic stability. However, the complex biological functions of these lncRNAs are unclear. Multivariate Cox proportional hazard regression analysis was applied to conduct lncRNA prognosis model.
13p vimahuateng 26-11-2021 3 0 Download
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Patients with gastric cancer have an increased nutritional risk and experience a significant skeletal muscle loss after surgery. We aimed to determine whether muscle loss during the first postoperative year and preoperative nutritional status are indicators for predicting prognosis.
11p vianrose2711 27-04-2021 7 1 Download
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The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. The purpose of this study was to determine the impact of surgery for the primary tumor in breast cancer patients with BM and to develop prognostic nomograms to predict the overall survival (OS) of breast cancer patients with BM.
18p vianrose2711 27-04-2021 9 2 Download