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Critical illness and injury
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Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury
Acute kidney injury (AKI) occurs frequently in critically ill patients and is associated with adverse out‑ comes. Cellular mechanisms underlying AKI and kidney cell responses to injury remain incompletely understood.
18p
viellison
28-03-2024
3
2
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There are significant differences in the incidence and risk factors of tumor patients, and there is no relevant statistical data. Therefore, this study aims to clarify the incidence and risk factors of acute kidney injury (AKI) in malignant tumor patients and compare critically ill patients with non-critically ill patients.
14p
vialfrednobel
23-12-2023
5
3
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Sequential physicochemical alterations in blood and urine in the course of acute kidney injury (AKI) development have not been previously described. We aimed to describe these alterations in parallel to traditional renal and acid–base parameters.
11p
viisaacnewton
26-04-2022
11
1
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Contrast medium used for radiologic tests can decrease renal function. However there have been few studies on contrast-associated acute kidney injury in intensive care unit (ICU) patients. The objective of this study was to evaluate the incidence, characteristics, and outcome of contrast-associated acute kidney injury (CA-AKI) patients using the Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) criteria in critically ill patients in the ICU.
8p
viisaacnewton
26-04-2022
10
1
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Hydroxyethyl starch (HES) is used for repletion of acute intravasal volume loss in surgical patients. However, in critically ill patients, HES is associated with acute kidney injury. We aimed to evaluate the effect of HES on perioperative cystatin C (cystC)-derived estimated glomerular filtration rates (eGFRcystC) in patients undergoing open and robot-assisted radical prostatectomy.
8p
viottohahn
30-03-2022
10
1
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Intradialytic hypotension is a serious complication during renal replacement therapy in critically ill patients. Early prediction of intradialytic hypotension could allow adequate prophylactic measures. In this study we evaluated the ability of peripheral perfusion index (PPI) and heart rate variability (HRV) to predict intradialytic hypotension.
5p
vizhangzhidong
29-12-2021
13
0
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Acute kidney injury (AKI) is strongly associated with high morbidity and mortality of critically ill patients. In the last years several different biological markers with higher sensitivity and specificity for the occurrence of renal impairment have been developed in order to promptly recognize and treat AKI.
7p
vizhangzhidong
29-12-2021
19
0
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Mechanical power (MP), defned as the amount of energy produced by mechanical ventilation and released into the respiratory system, was reportedly a determining factor in the pathogenesis of ventilator-induced lung injury. However, previous studies suggest that the efects of MP were proportional to their involvement in the total lung function size. Therefore, MP normalized to the predicted body weight (norMP) should outperform the absolute MP value.
9p
vidietmarhopp
29-12-2021
27
0
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Defined as the energy applied to the respiratory system by ventilator, mechanical power (MP) of ventilation defects the risk of ventilation-induced lung injury. This study aims to explore the relationship between dynamic changes in MP and prognosis in critically ill patients.
9p
vimackenziebezos
29-11-2021
14
1
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Acute lung injury (ALI) is characterized by a pro-coagulant state. Heparin is an anticoagulant with anti-inflammatory properties. Unfractionated heparin has been found to be protective in experimental models of ALI.
8p
vianthony2711
16-04-2021
9
1
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The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficiency (e.g. SCID with T and B cell deficiency) are particularly susceptible to the development of severe ARDS.
9p
vimontana2711
05-04-2021
8
2
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Studies investigating the role of hyperoxia in critically ill patients have reported conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients admitted to the intensive care unit (ICU).
11p
vimontana2711
05-04-2021
10
1
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Serum levels of N–terminal proB–type natriuretic peptide (NT–proBNP) are elevated in patients acute respiratory distress syndrome (ARDS). Recent studies showed a lower incidence of acute cor pulmonale in ARDS patients ventilated with lower tidal volumes. Consequently, serum levels of NT–proBNP may be lower in these patients.
7p
vimontana2711
05-04-2021
11
1
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Cardiac surgery is frequently complicated by an acute vascular lung injury and this may be mediated, at least in part, by the (soluble) receptor for advanced glycation end products (sRAGE).
7p
vimontana2711
05-04-2021
10
1
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The acute respiratory distress syndrome (ARDS) is a common, devastating complication of critical illness that is characterized by pulmonary injury and inflammation. The clinical diagnosis may be improved by means of objective biological markers.
9p
vimontana2711
05-04-2021
13
2
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Acute respiratory distress syndrome (ARDS) is potentially underrecognized by clinicians. Early recognition and subsequent optimal treatment of patients with ARDS may be facilitated by usage of biomarkers.
7p
vimaine2711
26-03-2021
9
2
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Hyperoxia is common early in the course of resuscitation of critically ill patients. It has been associated with mortality in some, but not all, studies of cardiac arrest patients and other critically ill cohorts.
7p
vimaine2711
26-03-2021
7
2
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The main aim of this study whether serum cystatin C can detect early changes in development of acute kidney injury compared to serum creatinine in critically ill patients and to study the confounding factors that normally can interfere in the analysis of serum creatinine. Serum cystatin C showed a faster increase in critically ill patients who were in the early stages of acute kidney injury compared to serum creatinine. Serum cystatin C showed superior sensitivity in adolescents, adults and in aged peoples compared to serum creatinine in detecting acute kidney injury.
7p
nguaconbaynhay6
24-06-2020
8
0
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Acute respiratory distress syndrome (ARDS) is among the most common causes of respiratory failure in critically ill patients. Despite extensive research, ARDS remains a major cause of morbidity and mortality, with no effective pharmacological treatment options. The present study was conducted to evaluate the efficacy of bone marrow-derived stem cells (BM-MSCs) compared with Dexamethasone (Dex) and Sodium bicarbonate (NaHCO3) against acute lung injury (ALI) induced by lipopolysaccharide (LPS) in rats.
15p
chauchaungayxua5
05-05-2020
21
2
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Dosing of antibiotics in critically ill patients is challenging. It becomes even more difficult if renal or hepatic impairment ensue. Modern means of renal replacement therapy are capable of removing antibiotics to a higher rate than decades ago, leaving clinicians with a high degree of uncertainty concerning the dose of antibiotics in this patient population.
5p
vienzym2711
03-04-2020
10
2
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