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Critical patient
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Paclitaxel is commonly used as a second-line therapy for advanced gastric cancer (AGC). The decision to proceed with second-line chemotherapy and select an appropriate regimen is critical for vulnerable patients with AGC progressing after first-line chemotherapy.
9p
vishanshan
27-06-2024
2
1
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Chemoradiotherapy is a critical treatment for patients with locally advanced and unresectable nonsmall cell lung cancer (NSCLC), and it is essential to identify high-risk patients as early as possible owing to the high incidence of radiation pneumonitis (RP). This study aimed to investigate the value of computed tomography (CT)-based radiomics combined with genomics in analyzing the risk of grade≥2 RP in unresectable stage III NSCLC.
10p
vishanshan
27-06-2024
1
1
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Intensive Care Unit (ICU) capacity management is essential to provide high-quality healthcare for critically ill patients. Yet, consensus on the most favorable ICU design is lacking, especially whether ICUs should deliver dedicated or non-dedicated care. The decision for dedicated or non-dedicated ICU design considers a trade-off in the degree of specialization for individual patient care and efficient use of resources for society.
9p
vishanshan
27-06-2024
1
1
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Health professionals in Colombian and many parts of the world, in some cases, work in precarious conditions and intend to migrate to other countries in search of better living conditions for themselves and their families, which results in inadequate distribution worldwide and in the quality of care throughout the health system, which can ultimately influence the quality of life of patients in their health-disease processes.
12p
vishanshan
27-06-2024
1
1
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Strong cultures of workplace safety and patient safety are both critical for advancing safety in healthcare and eliminating harm to both the healthcare workforce and patients. However, there is currently minimal published empirical evidence about the relationship between the perceptions of providers and staff on workplace safety culture and patient safety culture.
8p
vishanshan
27-06-2024
1
1
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Glycometabolism and lipid metabolism are critical in cancer metabolic reprogramming. The primary aim of this study was to develop a prognostic model incorporating glycometabolism and lipid metabolism-related genes (GLRGs) for accurate prognosis assessment in patients with endometrial carcinoma (EC).
21p
vishanshan
27-06-2024
2
1
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Combination therapy is the primary treatment for unresectable hepatocellular carcinoma (u-HCC). The hepatic functional reserve is also critical in the treatment of HCC. In this study, u-HCC was treated with combined hepatic arterial infusion chemotherapy (HAIC), tyrosine kinase inhibitors (TKIs), and programmed cell death protein-1 (PD-1) inhibitors to analyze the therapeutic response, progression-free survival (PFS), and safety.
10p
vishanshan
27-06-2024
2
1
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Tumor morphology, immune function, inflammatory levels, and nutritional status play critical roles in the progression of intrahepatic cholangiocarcinoma (ICC). This multicenter study aimed to investigate the association between markers related to tumor morphology, immune function, inflammatory levels, and nutritional status with the prognosis of ICC patients.
16p
vishanshan
27-06-2024
1
1
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Bladder cancer (BC) is among the most prevalent malignant urothelial tumors globally, yet the prognosis for patients with muscle-invasive bladder cancer (MIBC) remains dismal, with a very poor 5-year survival rate. Consequently, identifying more effective and less toxic chemotherapeutic alternatives is critical for enhancing clinical outcomes for BC patients.
15p
vikoch
27-06-2024
1
1
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Lung adenocarcinoma (LUAD) is a non-small cell carcinoma. Ribonuclease/angiogenin inhibitor 1 (RNH1) exerts multiple roles in virous cancers. E2F1 is a critical transcription factor involved in the LUAD development. Here, we analyze the expression of RNH1 in LUAD patients, investigate the biological function of RNH1 in LUAD, and demonstrate its potential mechanisms through E2F1 in LUAD.
17p
vikoch
27-06-2024
1
1
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Screening of cancer is the maximum effort and critical element for providing health related care in order to decrease cancer related dealt because of the disease burden is in its advanced stages. Unfortunately, advanced-stage presentation and late diagnosis of cancers endure a problem in low-income countries including Ethiopia. However, there is scarcity of published articles about the problem in Ethiopia.
8p
vikoch
27-06-2024
1
1
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Predicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for patients with breast cancer; however, there are no reliable biomarkers that can effectively assess tumor responses. Therefore, we aimed to evaluate the clinical feasibility of using extracellular vesicles (EVs) to predict tumor response after NAC.
12p
vikoch
27-06-2024
1
1
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This is a comprehensive, one-of-a-kind question-and-answer text for medical professionals and apprentices concentrating on the growing subspecialty of surgery in critical care and emergency surgery. Covering all surgical aspects of critical care and acute or emergency surgery, it is an ideal learning and review text for surgical residents and trainees who care for these patients and those taking the Surgical Critical Care Board Examination.
521p
vimeyers
29-05-2024
2
1
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In the time that has elapsed since the publication of the first edition, significant advances have altered the way we care for surgical patients. Continuing progress in surgical critical care enables us to operate an older and sicker patients. More effective means of maintaining adequate circulation and oxygenation in the face of sepsis and other complications continue to reduce surgical mortality.
901p
vimeyers
29-05-2024
3
2
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The aim of this study was to assess the safety of laparoscopic cholecystectomy using "The Critical View of Safety" (CVS) technique for the management of gallbladder stone disease. Prospective study, describing a series of cases of patients undergoing laparoscopic cholecystectomy with CVS applied to treat gallbladder stones at Binh Dan Hospital from January 2022 to October 2022.
10p
vicarlos
16-05-2024
1
1
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Part 1 book "Feline emergency and critical care medicine" includes contents: Approach to the critically ill cat, cardiopulmonary resuscitation (cpr), shock, trauma, anesthesia for critically ill feline patient, anesthetic protocols for systemically healthy cats, analgesia in the critically ill cat, fluid therapy, nutritional support for the critically ill feline patient, respiratory emergencies and pleural space disease, upper airway disease, lower airway disease,... and other contents.
288p
dianmotminh01
14-05-2024
0
0
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Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.
22p
vibransone
28-03-2024
3
2
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Solid tumors such as pancreatic ductal adenocarcinoma (PDAC) comprise not just tumor cells but also a microenvironment with which the tumor cells constantly interact. Detailed characterization of the cellular composition of the tumor microenvironment is critical to the understanding of the disease and treatment of the patient.
14p
vibransone
28-03-2024
4
2
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Understanding longitudinal variability of the microbiome in ill patients is critical to moving microbiomebased measurements and therapeutics into clinical practice. However, the vast majority of data regarding microbiome stability are derived from healthy subjects.
14p
vioraclene
31-03-2024
3
2
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Mutations in the DMD gene encoding dystrophin—a critical structural element in muscle cells— cause Duchenne muscular dystrophy (DMD), which is the most common fatal genetic disease. Clustered regularly interspaced short palindromic repeat (CRISPR)-mediated gene editing is a promising strategy for permanently curing DMD.
19p
vibransone
28-03-2024
5
2
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