Curative therapy
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CCRT is presently the standard treatment for LA-NSCLC. RP is one of the main obstacles to the completion of thoracic radiation therapy, resulting in limited survival benefits in NSCLC patients. This research aims to explore the role of Endostar in the occurrence of grade≥2 RP and clinical curative effect in LA-NSCLC patients.
10p vikoch 27-06-2024 1 1 Download
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Chemotherapy is included in treatment regimens for many solid cancers, but when administered as a single agent it is rarely curative. The addition of immune checkpoint therapy to standard chemotherapy regimens has improved response rates and increased survival in some cancers.
11p vikoch 27-06-2024 1 1 Download
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Surgical resection of gallbladder cancer with negative margins is the only potentially curative therapy. Most patients with gallbladder cancer are diagnosed in an advanced stage and, despite the availability of several chemotherapies, the prognosis remains dismal.
8p vigojek 02-02-2024 2 1 Download
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For patients with oesophagogastric adenocarcinoma, surgery is the only curative option and despite the use of multimodality therapy, which combines it with chemotherapy and/or radiotherapy, more than 50% of patients will relapse and die. Many UK patients present with advanced disease which is already inoperable or metastatic at diagnosis.
13p vileonardodavinci 23-12-2023 5 3 Download
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Surgical resection followed by indicated adjuvant therapy offers potential curative treatment in colonic adenocarcinoma. Beyond the well-established seed and soil theory of colon cancer progression, the ’normal-appearing’ tissues near the tumor are not genuinely normal and remain as remnants in patients following surgery.
14p vileonardodavinci 23-12-2023 9 2 Download
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A majority of patients undergoing curative-intent surgery for pancreatic ductal adenocarcinoma (PDAC) will unfortunately develop recurrent disease. Treatment outcomes for patients with metastatic disease remain suboptimal. In this study, we evaluated clinical outcomes of patients with recurrent PDAC who received systemic therapy and compared outcomes to patients with de novo metastatic PDAC undergoing systemic therapy.
8p vialfrednobel 23-12-2023 4 3 Download
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Little is known about predictive factors for survival outcomes of esophageal carcinoma (EC) patients who developed recurrence after undergoing multimodal therapies. We aimed to investigate long-term outcomes and identify prognostic factors in patients with relapsed EC, focusing especially on those with oligometastasis (OM).
11p vialfrednobel 23-12-2023 3 2 Download
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Prostate cancer patients with locoregional lymph node disease at diagnosis (N1M0) still have a limited prognosis despite the improvements provided by aggressive curative intent multimodal locoregional external beam radiation therapy (EBRT) with systemic androgen deprivation therapy (ADT).
13p vischultz 20-10-2023 4 1 Download
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The role of ATF2 in colon cancer (CC) is controversial. Recently, we reported that low ATF2 expression is characteristic of highly invasive tumors, suggesting that ATF2 might also be involved in therapy resistance. 5-Fluoro-uracil (5-FU) is the best-known chemotherapeutic drug for CC, but drug resistance affects its curative effect.
15p visharma 20-10-2023 5 2 Download
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The goal of therapy for many patients with advanced stage malignancies, including those with metastatic gastric and esophageal cancers, is to extend overall survival while also maintaining quality of life. After weighing the risks and benefts of treatment with palliative chemotherapy (PC) with non-curative intent, many patients decide to pursue treatment.
9p vioracle 29-09-2023 5 3 Download
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In hepatocellular carcinoma (HCC), locoregional therapy (LRT) included transarterial chemotherapy embolization - TACE is performed as a bridging or downstaging treatment, improved overall survival, or a curative treatment. Liver Imaging Reporting and Data Systems (LI-RADS) Treatment Response was created to evaluate each lesion post-TACE, which has localized and is suitable for determining whether the tumor is still viable or non-viable.
8p vigamora 23-05-2023 5 2 Download
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Adrenal insufficiency is a life-threatening condition, and advanced gastric cancer is associated with very poor prognosis. Adrenalectomy and/or metastatic invasion of the adrenal glands can cause primary adrenal insufficiency, which in turn can present with symptoms mimicking advanced cancer.
5p vidoctorstrange 06-05-2023 5 2 Download
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Borderline resectable pancreatic cancer (BRPC) is a category of pancreatic cancer that is anatomically widely spread, and curative resection is uncommon with upfront surgery. Intensity-modulated radiation therapy (IMRT) is a form of radiation therapy that delivers precise radiation to a tumor while minimizing the dose to surrounding normal tissues.
11p vipriyankagandhi 27-07-2022 10 1 Download
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We aimed to investigate response and prognostic factors in patients with human epidermal growth factor receptor 2 (HER2) positive metastatic colorectal cancer (mCRC) and compare the curative effects on patients who received different therapy regimens (including chemotherapy and chemotherapy combined with targeted drugs).
9p viangelamerkel 27-07-2022 3 1 Download
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The only curative therapy for renal cell carcinoma is the complete removal of malignant tissue. Surgical bleeding during radical nephrectomy may require blood transfusion. Blood transfusion, however, is associated with postoperative morbidity and mortality.
7p viisaacnewton 25-04-2022 7 1 Download
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The mixed-lineage leukemia (MLL) gene is located on chromosome 11q23. The MLL gene can be rear‑ ranged to generate partial tandem duplications (MLL-PTD), which occurs in about 5-10% of acute myeloid leukemia (AML) with a normal karyotype and in 5-6% of myelodysplastic syndrome (MDS) patients. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently one of the curative therapies available for AML and MDS with excess blasts (MDS-EB).
11p vielonmusk 21-01-2022 9 0 Download
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Palliative care is patient and family-centered care that optimizes quality of life by anticipating, preventing, and treating suffering when “curative” therapies are futile. In the Intensive Care Unit (ICU), critically ill patients receive life-sustaining therapies with the goal of restoring or maintaining organ function.
6p vampires36 30-12-2021 20 0 Download
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Despite extensive pharmacological approaches, there is no curative therapy for Alzheimer’s disease (AD) or other types of dementias. While current pharmacological options alleviate some symptoms of AD, they can lead to various adverse effects. Hence, nonpharmacological treatment options for AD are often considered with the assumption that they are safe, effective, and economic in managing patients.
9p dolomite36 30-12-2021 12 0 Download
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Locally recurrent rectal cancer (LRRC) remains a major problem after curative resection of primary rectal cancer. A noninvasive, prognostic biomarker with which to accurately evaluate disease status and assess the treatment response is critically needed to optimize treatment plans. This study assesses the effectiveness of PET/CT evaluation of preoperative chemoradiation therapy (CRT) in patients with LRRC.
10p vimahuateng 26-11-2021 12 2 Download
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The role of muscle depletion and visceral adiposity in HCC patients aged 65 and over undergoing TACE
The incidence of hepatocellular carcinoma (HCC) has been increasing among the elderly populations. Trans-arterial chemoembolization (TACE), a widely used first-line non-curative therapy for HCCs is an issue in geriatrics. We investigated the prognosis of elderly HCC patients treated with TACE and determined the factors that affect the overall survival.
11p vimahuateng 26-11-2021 12 3 Download