Cyclic lipodepsipeptide

Phomafungin is a recently reported broad spectrum antifungal compound but its biosynthetic pathway is unknown. We combed publicly available Phoma genomes but failed to find any putative biosynthetic gene cluster that could account for its biosynthesis.

18p visilicon2711 20-08-2021 12 1   Download

Daptomycin and A21987C antibiotics are branched, cyclic, nonribosomally assembled acidic lipodepsipeptides produced byStreptomyces roseosporus. The antibacterial activity of daptomycin against Gram-positive bacteria strongly depends on the nature of the N-terminal fatty acid moiety.

7p vinaphone15 28-02-2013 24 1   Download