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Cysteine Protein Domain
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Whey acidic protein (WAP) is a major protein identified in the milk of several mammalian species with cysteine-rich domains known as four-disulfide cores (4-DSC). The organization of the eutherian WAP genes is highly conserved through evolution.
10p
vihagrid
30-01-2023
3
3
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HA is a membrane bound homotrimer in the influenza virus envelope, and the purified rHA protein assembles into higher order rosette structures in the final formulation of the vaccine.
20p
viuchiha2711
21-04-2020
12
1
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Recombinant protein purification is a crucial step for biochemistry and structural biology fields. Rapid robust purification methods utilize various peptide or protein tags fused to the target protein for affinity purification using corresponding matrices and to enhance solubility.
11p
vihamax2711
21-04-2020
33
0
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The activity of m-calpain, a heterodimeric, Ca 2+ -dependent cysteine protease appears to be modulated by membrane interactions involving oblique-orientated a-helix formation by a segment, GTAMRILGGVI, in the protein’s smaller subunit. Here, graphical and hydrophobic moment-based analyses predicted that this segment may form ana-helix with strong structural resemblance to the influenza virus peptide, HA2, a known oblique-orientateda-helix former.
9p
tumor12
22-04-2013
30
1
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The goal of this study was to relate conformational changes in the N-terminal domain of chicken troponin I (TnI) to Ca 2+ activation of the actin–myosin interaction.The two cysteine residues in this region (Cys48 and Cys64) were labeled with two sulfhydryl-reactive pyrene-containing fluorophores [N-(1-pyrene)maleimide, and N-(1-pyrene)-iodoacetamide].The labeled TnI showed a typical fluores-cence spectrum: two sharp peaks of monomer fluorescence and a broad peak of excimer fluorescence arising from the formation of an excited dimer (excimer)....
9p
tumor12
20-04-2013
40
1
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PDZ domains are protein–protein interaction modules that are crucial for the assembly of structural and signalling complexes. They specifically bind to short C-terminal peptides and occasionally to internal sequences that structurally resemble such peptide termini. The binding of PDZ domains is dominated by the residues at the P 0 and P )2 position within these C-ter-minal targets, but other residues are also important in determining specific-ity.
11p
fptmusic
11-04-2013
31
1
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The tumor suppressor protein, p53, selectively binds to supercoiled (sc) DNA lacking the specific p53 consensus binding sequence (p53CON). Using p53 deletion mutants, we have previously shown that the p53 C-terminal DNA-binding site (CTDBS) is critical for this binding.
12p
awards
05-04-2013
40
4
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Metallothioneins are typically low relative molecular mass (6000–7000), sulfhydryl-rich metal-binding proteins with characteristic repeating cysteine motifs (Cys-X-Cys or Cys-Xn-Cys) and a prolate ellipsoid shape containing single a-andb-domains. While functionally diverse, they play important roles in the homeostasis, detoxification and stress response of metals. The originally reported metallothionein of the American oyster,Crassostrea virginicashowed the canonical molluscanab-domain structure. ...
11p
dell39
03-04-2013
46
3
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Collectins are a family of collagenous calcium-dependent defense lectins in animals. Their polypeptide chains consist of four regions: a cysteine-rich N-terminal domain,a colla-gen-like region,ana-helical coiled-coil neck domain and a C-terminal lectin or carbohydrate-recognition domain. These polypeptide chains form trimers that may assemble into larger oligomers. The best studied family members are the mannan-binding lectin,which is secreted into the blood by the liver,and the surfactant proteins A andD,which are secreted into the pulmonary alveolar and airway lining fluid....
21p
dell39
03-04-2013
41
4
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The protein ataxin-3 is responsible for spinocerebellar ataxia type 3, a neu-rodegenerative disease triggered when the length of a stretch of consecutive glutamines exceeds a critical threshold. Different physiologic roles have been suggested for this protein. More specifically, recent papers have shown that the highly conserved N-terminal Josephin domain of ataxin-3 binds ubiquitin and has ubiquitin hydrolase activity, thanks to a catalytic device specific to cysteine proteases.
10p
inspiron33
25-03-2013
30
3
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Snake venom metalloproteinases (SVMPs) have recently been shown to interact with proteins containing von Willebrand factor A (VWA) domains, including the extracellular matrix proteins collagen XII, collagen XIV, mat-rilins 1, 3 and 4, and von Willebrand factor (VWF) via their cysteine-rich domain.
11p
galaxyss3
19-03-2013
39
2
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In recent years, classical antibody-based affinity reagents have been challenged by novel types of binding proteins developed by combinatorial protein engineering principles. One of these classes of binding proteins of non-Ig origin are the so-called affibody binding proteins, functionally selected from libraries of a small (6 kDa), non-cysteine three-helix bundle domain used as a scaffold.
9p
galaxyss3
07-03-2013
40
3
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Metallothioneins (MTs) are cysteine-rich, metal-binding proteins known to provide protection against cadmium toxicity in mammals. Metal exchange of Zn 2+ ions for Cd 2+ ions in metallothioneins is a critical process for which no mechanistic or structural information is currently available.
13p
media19
06-03-2013
45
2
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Human Brox is a newly identified 46 kDa protein that has a Bro1 domain-like sequence and a C-terminal thioester-linkage site of isoprenoid lipid (CAAX motif) (C standing for cysteine, A for generally aliphatic amino acid, and X for any amino acid).
11p
media19
05-03-2013
28
1
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The determination of the receptor-binding region of Cry toxins produced byBacillus thuringiensisis expected to facilitate an improvement in their insecticidal ability through protein engineering. We analyzed the region on Cry1Aa molecules involved in interactions with the cadherin-like protein receptor BtR175 using cysteine-substituted mutant toxins and several syn-thetic peptides corresponding to the loops in domain 2.
11p
viettel02
20-02-2013
37
2
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The peptide antibiotic bacitracin is widely used as an inhibitor of protein disulfide isomerase (PDI) to demonstrate the role of the protein-folding catalyst in a variety of molecular pathways. Commercial bacitracin is a mixture of at least 22 structurally related peptides.
10p
cosis54
05-01-2013
41
3
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function
11p
dauphong7
13-01-2012
30
2
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