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Cytotoxic activity
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Although immune cell therapy has long been used for treating solid cancer, its efficacy remains limited. Interferon (IFN)-producing killer dendritic cells (IKDCs) exhibit cytotoxicity and present antigens to relevant cells; thus, they can selectively induce tumor-associated antigen (TAA)-specific CD8 T cells and may be useful in cancer treatment.
12p
vishanshan
27-06-2024
2
1
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In this research, we fabricated α-mangostin-loaded liposomes from soybean lecithin and cholesterol to enhance the solubility in water of α-mangostin and reduce side effects in the treatment of cancer.
11p
viamancio
04-06-2024
2
0
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The present study reported the isolation, elucidation of compounds from the whole plant and their cytotoxic activities on Hep G2 (HB - 8065TM, hepatocellular carcinoma), A549 (CCL-185™, pulmonary adenocarcinoma), and MCF-7 (HTB - 22TM, breast cancer) cell lines. As a result, velutin exhibited the most significant cytotoxicity against Hep G2, A549, and MCF-7 cell lines with IC50 values of 34.00, 30.85, and 41.33 μg/mL, respectively.
4p
vicarlos
16-05-2024
1
0
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In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK-293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginseng sprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6-year old roots.
7p
dianmotminh02
03-05-2024
4
1
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Phytochemical study of Knema pachycarpa leaves led to the isolation of ten compounds. Their chemical structures were determined as (7''R, 8''R)-hydnocarpin D, (7''R, 8''R)-hydnocarpin, sinaicitin, (-)-globulol, β-caryolanol, phytol, biochanin A, chrysoeriol, tanoside II and astragalin using NMR and MS spectral data. Among the isolates, (7''R, 8''R)-hydnocarpin showed good cytotoxic activity against KB, HepG-2, Lu and MCF-7 cancer cell lines with IC50 values from 13.99±0.62 ug/mL to 30.65±1.44 ug/mL.
6p
dianmotminh02
03-05-2024
1
1
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The winged-helix domain within the N-terminus of human MUS81 has been considered as potential target for drug development since the inhibition of this protein might significantly enhance the sensitivity of various cancer cells towards anticancer drugs. Nine cytotoxic triterpenoids previously purified from Helicteres hirsuta and Pterospermum truncatolobatum were selected for the docking experiment.
6p
dianmotminh02
03-05-2024
1
1
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Alpinia vietnamica H.Ð. Tran, Luu & Skornick was identified as a new species in 2019, which is widely distributed in Thua Thien Hue, Quang Nam, and Kon Tum provinces, Vietnam. The current study wishes to report phytochemical investigation, and the biological activities (cytotoxic, antioxidative, and α-glucosidase inhibitory) of isolated compounds.
5p
dianmotminh02
03-05-2024
7
1
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The methanol extracts as well as some compounds from this plant exhibited anti-inflammatory, antimicrobial activity, antioxidant, hepatoprotective and anti-cancer effect, and antiosteoporotic. On going to search for bioactive components from the Vietnamese plant, this paper reported the isolation of seven phenolic compounds including one new from the aerial parts of A. ilicifolius. The cytotoxic activity of the isolates against two cancer cell lines (HepG2 and SK-LU1) were also screened and reported herein.
5p
dianmotminh02
03-05-2024
5
1
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The essential oils were also tested for their antioxidant, anti-imflammatory, antimicrobial and cytotoxic activities. The HD essential oil sample showed inhibitory activity against 6/8 tested microorganisms, i.e., Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus subtillis, Candida albicans, and Saccharomyces cerevisiae. The MHD and EHD exhibited the inhibitory activity against three strains E. coli, A. niger and F. oxysporum. The UHD inhibited E. coli and F. oxysporum.
9p
dianmotminh02
03-05-2024
7
1
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Zoanthid is a potential natural resource with many biological activities, such as antioxidant, antiviral, antiinflammatory, and cytotoxic activity. Therefore, this study aimed to evaluate the antioxidant activity of 70% ethanol crude extract and dichloromethane fraction from Zoanthus vietnamensis. The total polyphenol content of ethanol and dichloromethane extracts were 19.36 ± 1.37 and 24.95 ± 0.63 mg GAE/g extract, respectively.
9p
dianmotminh02
03-05-2024
4
1
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In this work, a new sulfated polysaccharide was isolated from green seaweed Caulerpa racemosa harvested at Nha Trang sea. The structure of obtained polysaccharide was determined and its cytotoxic activity was evaluated. The results showed that structure of the polysaccharide has a main chain of (1→4)-β-D-galactopyranose residues and branches are (1→3)-α-L-glucopyranose-2,4-disulfate residues linked to the main chain at C-6 position.
6p
dianmotminh02
03-05-2024
2
1
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This compound converted to Mannich base which interne illustrated as tridentate ligand of NO2-type. Meanwhile, the organic synthesis of the compounds is not an easy task, especially lactonization; hint naphthafuran-2-one has never been prepared from amino nitrile previously. Selected metal ions of known anticancer activity interacted with the ligand to present novel complexes to figure out the cytotoxicity effect of both organic and inorganic parts against cancer cell line.
10p
dianmotminh02
03-05-2024
1
1
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The synthesized compounds' enzyme inhibition potential was tested against a-glucosidase, AChE, and BChE enzymes. As illustrated from the results of IC50, these compounds are observed as the active inhibitory potential for these enzymes. The cytotoxic activity by hemolytic Assay revealed that these compounds have mild exposure to cytotoxicity on RBCs.
10p
visergey
02-04-2024
0
0
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Ebook "Natural compounds as inducers of cell death: Volume 1" gives a multi-disciplinary approach into the anti-cancer research field related to natural products and dietary compounds. Mainly, it covers the area of antitumor activity through an in-depth description of the cytotoxic, anti-inflammatory and anti-oxidant properties in cancer, inflammatory and cardio-vascular diseases.
512p
manmanthanhla0201
26-02-2024
5
1
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Ebook "Q’eqchi’ maya reproductive ethnomedicine" have an extensive pharmacopoeia of medicinal plants used traditionally for reproductive health and fertility, utilizing more than 60 plant species for these health treatments. Ten species were selected for investigation of their estrogenic activity using a reporter gene assay. Nine of the species were estrogenic, four of the species were also antiestrogenic, and two of the extracts were cytotoxic to the MCF-7 breast cancer cell line.
134p
manmanthanhla0201
26-02-2024
2
1
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This study aimed to determine the cytotoxic activity on cancer cells of A549, Hep3B, MCF-7 of lignans, and monoterpenoids isolated from the male Carica papaya flowers in Quangnam - Danang.
6p
vigojek
02-02-2024
0
0
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Liver cancer and breast cancer have high death rates and tend to increase rapidly in recent years in Vietnam and over the world. Currently, the study of bioactive compounds isolated from plants for killing cancer cells is of interest. The study aims to identify the cytotoxicity using MTT assay of Combretum quadrangulare Kurz fractions against MCF-7 cells.
10p
vibego
02-02-2024
0
0
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Several novel of polymethoxyquercetin Mannich base derivatives (2-7) were synthesized through O-methylation and based on Mannich reaction with various secondary amines and formaldehyde, starting from abundant and inexpensive natural sources quercetin.
8p
vimarillynhewson
02-01-2024
1
1
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In the last few decades, pyrazoline-based substances have emerged as potential antimicrobial and anticancer candidates. In concern with antimicrobial activity, this study aims to build a docking model to predict the structure of potential 2-pyrazoline derivatives. The cytotoxicity of some compounds was also evaluated to get insight into the structure–anticancer activity relationship of the 2- pyrazoline derivatives.
8p
vikissinger
21-12-2023
2
1
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Hepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alterations in telomerase reverse transcriptase promoter (TERTp) and β-catenin (CTNNB1) genes and immune cell activation in the tumor microenvironment. As a novel approach, we wanted to assess patient survival influenced by combined presence of mutations and densities of CD8+ cytotoxic T cells.
10p
vialfrednobel
23-12-2023
4
3
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