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Cytotoxic TNFα
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Photodynamic therapy (PDT) applications enable light-controlled activation of drug candidates instead of their constitutive activities to prevent undesired side effects associated with their constant activities. A specific wavelength of light is utilized to enable electron mobility in the chemical structure, which results in differential activities that may alter cell viability and cellular functions. Canonical photodynamic therapy applications mostly focus on cytotoxicity-based antimicrobial and anticancer properties of the PDT agents.
9p
langthannam
29-12-2021
10
1
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MicroRNAs have been shown to be important regulators of the immune response and the development of the immune system. It was reported that microRNA-125b (miR-125b) was down-regulated in macrophages challenged with endotoxin.
10p
vinaypyidaw2711
26-08-2020
7
2
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Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been well characterized in MCF7 luminal A breast cancer cells.
17p
viputrajaya2711
22-06-2020
11
1
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Study indicated that F. lini was able to catalyze dehydrogenation reactions selectively. Structures of compounds 1–14 were determined through NMR, HRFAB-MS, and IR spectroscopic data. Compounds 1–14 were identified as non-cytotoxic against BJ human fibroblast cell line (ATCC CRL-2522). Metabolite 5 (81.0 ± 2.5%) showed a potent activity against TNF-a production, as compared to the substrate 1 (62.5 ± 4.4%). Metabolites 2 (73.4 ± 0.6%), 8 (69.7 ± 1.4%), 10 (73.2 ± 0.3%), 11 (60.1 ± 3.3%), and 12 (71.0 ± 7.2%), also showed a good inhibition of TNF-a production. Compounds 3 (IC50 = 4.4 ± 0.
10p
partimesinhvien
08-05-2020
12
1
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Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is amember of theTNFfamilyandapotent inducer of apoptosis. TRAIL has been shown to effectively limit tumor growthin vivowithout detectable cytotoxic side-effects. Interferon (IFN)-coften modulates the anticancer activities of TNF family members including TRAIL. How-ever, little is known about the mechanism. To explore the mechanism, A549, HeLa, LNCaP, Hep3B andHepG2 cells were pretreated with IFN-c, and then exposed to TRAIL.
7p
awards
05-04-2013
46
2
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