Damage patterns
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Exosomes are promising tools for improving cancer care, but conversely may also contribute to tumor progression. Here, we highlight recently discovered roles of exosomes in modulating immune responses in cancer, with emphasis on exosomal surface proteins and on RNA and DNA content. We also discuss how exosomes could be exploited as biomarkers and delivery vehicles in cancer therapy.
4p vibransone 28-03-2024 2 2 Download
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The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses in tumors with high mutational burden.
10p vibransone 28-03-2024 6 2 Download
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Older adults with hypertension face an increased risk of adverse cardiovascular outcomes, emphasizing the importance of target organ damage (TOD) in their treatment. The nondipping blood pressure (BP) pattern, characterized by inadequate reduction of nocturnal BP (less than 10-20%), is associated with a higher likelihood of TOD in individuals with essential hypertension. This study aimed to examine the characteristics of non-dipping BP patterns among elderly individuals with essential hypertension and evaluate their associations with TOD.
11p vigeorge 06-12-2023 1 1 Download
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The aim of the research was the processing of the vibration signatures from healthy and damaged composite beams acquired with the help of a Scanning Laser Vibrometer (SLV) upon excitation and analysis of the mode shapes acquired for damage detection. The displacement mode shapes acquired were then converted into curvature mode shapes with the help of a Central Difference Approximation method (CDA).
146p runthenight07 01-03-2023 5 2 Download
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(BQ) Ebook Transmission electron microscopy: A textbook for materials science - Part 1 includes the following content: The transmission electron microscope; scattering and diffraction; elastic scattering; inelastic scattering and beam damage; electron sources; lenses, apertures, and resolution; how to ‘see’ electrons; pumps and holders; the instrument; specimen preparation; diffraction in TEM; thinking in reciprocal space; diffracted beams; bloch waves; dispersion surfaces; diffraction from crystals; diffraction from small volumes; obtaining and indexing parallel-beam diffraction patterns; ...
318p runordie6 06-08-2022 6 0 Download
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Aspiration-induced lung injury can decrease gas exchange and increase mortality. Acute lung injury following acid aspiration is characterized by elevated pulmonary blood flow (PBF) in damaged lung areas in the early inflammation stage. Knowledge of PBF patterns after acid aspiration is important for targeting intravenous treatments. We examined PBF in an experimental model at a later stage (2 hours after injury).
9p viisaacnewton 26-04-2022 6 1 Download
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Plant domestication provides a unique model to study genome evolution. Many studies have been conducted to examine genes, genetic diversity, genome structure, and epigenome changes associated with domestication.
16p vigalileogalilei 27-02-2022 14 1 Download
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Tear film (TF) helps maintain and protect ocular function against damage to the ocular surface. Proteins are one of its main constituents, whose expression pattern can be used as a biomarker of ocular changes and systemic diseases.
16p vidarwin 22-02-2022 17 1 Download
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Homologous recombination (HR) repair deficiency arising from defects in BRCA1 or BRCA2 is associated with characteristic patterns of somatic mutations. In this genetic study, we ask whether inactivating mutations in further genes of the HR pathway or the DNA damage checkpoint also give rise to somatic mutation patterns that can be used for treatment prediction.
13p vielonmusk 30-01-2022 15 0 Download
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The 2020 Samos, M7.0 earthquake was characterized by an unusual bi-modal-type distribution of damage: limited damage in the nearfield (especially northern Samos coast) and serious localized damage in multi-story buildings in the far field (İzmir area). This pattern is not consistent with the typical distribution of isoseismal lines, and it seems not to represent an isolated effect; the 2014 Samothraki- Gökçeada M6.9 earthquake, for example, may in fact represent a parallel, though at smaller scale.
10p tanmocphong 29-01-2022 9 0 Download
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Contamination from present-day DNA is a fundamental issue when studying ancient DNA from historical or archaeological material, and quantifying the amount of contamination is essential for downstream analyses.
16p viarchimedes 26-01-2022 11 0 Download
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The dramatic increase in urban settlements and reduction in green cover and water bodies will damage the environmental sustainability of Rajshahi city by increasing temperature and heatwaves. This study will help the urban planners and policymakers to make proper sustainable development decisions by understanding the LU/LC changing pattern.
11p thebadguys 15-01-2022 14 0 Download
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Postoperative remote lung injury is a complication following various surgeries and is associated with short and long-term mortality and morbidity. The release of proinflammatory cytokines, damage-associated molecular patterns such as high-mobility group box-1, nucleotide-biding oligomerization domain (NOD)-like receptor protein 3 and heat shock protein, and cell death signalling activation, trigger a systemic inflammatory response, which ultimately results in organ injury including lung injury.
10p vampires36 30-12-2021 12 0 Download
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There is little knowledge, whether in patients with sepsis neutrophil extracellular trap (NET) formation and NET degrading nuclease activity are altered. Thus, we tested the hypotheses that 1) NET formation from neutrophils of septic patients is increased compared to healthy volunteers, both without stimulation and following incubation with mitochondrial DNA (mtDNA), a damage-associated molecular pattern, or phorbol 12-myristate 13-acetate (PMA; positive control) and 2) that serum nuclease activities are increased as well.
9p vizhangzhidong 29-12-2021 10 0 Download
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The aim of the current study was to examine the effect of black ash carbon nanofibers (CNFs) on gamma-aminobutyric acid (GABA) shunt pathway in germinating seeds of tomato (Lycopersicon esculentum Mill., c.v. Rohaba) under salt stress. Seed’s germination pattern, seed moisture content, GABA shunt metabolite levels (GABA, Glutamate and Alanine), total proteins and total carbohydrates, and the level of oxidative damage in response to sodium chloride (NaCl) treatments were determined.
16p tudichquannguyet 29-11-2021 12 3 Download
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Trees such as Populus are planted extensively for reforestation and afforestation. However, their successful establishment greatly depends upon ambient environmental conditions and their relative resistance to abiotic and biotic stresses. Polyphenol oxidase (PPO) is a ubiquitous metalloproteinase in plants, which plays crucial roles in mediating plant resistance against biotic and abiotic stresses.
15p vilarryellison 29-10-2021 6 1 Download
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The deubiquitinase (DUB) family constitutes a group of proteases that regulate the stability or reverse the ubiquitination of many proteins in the cell. These enzymes participate in cell-cycle regulation, cell division and differentiation, diverse physiological activities such as DNA damage repair, growth and development, and response to stress.
16p vijeeni2711 24-07-2021 15 0 Download
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Using the data from an original survey, we analyse energy use patterns and, in particular, energy use for cooking in households from Hawassa City, Southern Ethiopia. Cooking is the main energy-related activity on which households spend money. This expenditure represents 89% of total energy expenditure and a fifth of a household’s total budget. Expenditure on modern energy and electricity represents only about a fifth of an energy budget, whilst fuelwood, a potentially health damaging energy, still prevails as the main energy used for cooking in Hawassa.
10p caygaocaolon11 18-04-2021 16 2 Download
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MRI is the most accurate imaging modality for diagnosing knee pathologies. However, there is uncertainty concerning factors predicting false negative MRI, such as meniscal tear patterns as well as patient factors.
9p vianttinic2711 20-04-2021 7 2 Download
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Activation and polarization of circulating monocytes in severe chronic obstructive pulmonary disease
The ability of circulating monocytes to develop into lung macrophages and promote lung tissue damage depends upon their phenotypic pattern of differentiation and activation. Whether this phenotypic pattern varies with COPD severity is unknown.
10p vimontana2711 05-04-2021 12 2 Download