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Damaging family
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The genetic risk for pancreatic cancer is often shared with breast cancer susceptibility genes, most notably BRCA2, PALB2, ATM and BRCA1. Therefore, we hypothesized that additional shared genetic etiologies might be uncovered by studying families presenting with both breast and pancreatic cancer.
9p
vikoch
27-06-2024
2
1
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In ebook "Synthetic and biophysical studies on the tridachiahydropyrone family of natural products" methodology for the palladium-catalysed cyanation of vinyl halides with acetone cyanohydrin was developed. Conditions were optimised using β-bromostyrene, and shown to be applicable to a range of diverse substrates.
147p
tracanhphuonghoa1007
22-04-2024
4
3
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Sudden unexpected death in children is a tragic event. Understanding the genetics of sudden death in the young (SDY) enables family counseling and cascade screening. The objective of this study was to characterize genetic variation in an SDY cohort using whole genome sequencing.
13p
vicwell
29-02-2024
4
2
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Monitoring of power transmission lines plays an important task in high voltage transmission systems. The problem of damaged insulator causes bad effects on an electrical power grid. To make sure the power grid worked properly, electrical personnel usually need to be climbed on the electric post to inspect them which consists of risk latent in occupational safety.
9p
vicaptainmarvel
21-04-2023
14
4
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(BQ) Ebook Studies on renal disorders: Part 1 presents the following content: Oxidative stress injury in glomerular mesangium; transition metals and other forms of oxidative protein damage in renal disease; cyclooxygenase in the kidney and oxidative stress; renin-angiotensin system in the kidney and oxidative stress: local renin-angiotensin-aldosterone system and nadph oxidase-dependent oxidative stress in the kidney; thiamine in diabetic renal disease: dietary insufficiency, renal washout, antistress gene response, therapeutic supplements, risk predictor, and link to genetic susceptibility...
426p
runordie7
30-08-2022
5
2
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Sevoflurane is commonly usedin pediatric anesthesia due to its non-irritating airway properties, and rapid induction and emergence. However, it is associated with emergence agitation (EA) in children. EA may cause injury to the child or damage to the surgical site and is a cause of stress to both caregivers and families.
7p
viottohahn
30-03-2022
9
1
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CRISPR/Cas has recently been transferred to plants to make them resistant to geminiviruses, a damaging family of DNA viruses. We discuss the potential and the limitations of this method.
4p
viaristotle
29-01-2022
7
0
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Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chromatin interactions in mitosis. These compact chromatin and create mechanically stable chromosomes.
25p
viarchimedes
26-01-2022
5
0
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Inflammasomes are supramolecular protein complexes implicated in the detection of pathogens or danger-associated molecules and are responsible for mounting the first line of innate immune response to counteract these signals and restore tissue homeostasis. Among different inflammasomes identified so far, NLRP3 is of main interest since mutations in Nlrp3 gene are associated with autoinflammatory diseases such as Muckle–Wells syndrome, neonatal onset multisystem inflammatory disease, and familial cold urticaria/autoinflammatory syndrome.
11p
thiencuuchu
27-11-2021
9
1
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Trees such as Populus are planted extensively for reforestation and afforestation. However, their successful establishment greatly depends upon ambient environmental conditions and their relative resistance to abiotic and biotic stresses. Polyphenol oxidase (PPO) is a ubiquitous metalloproteinase in plants, which plays crucial roles in mediating plant resistance against biotic and abiotic stresses.
15p
vilarryellison
29-10-2021
6
1
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Understanding the genetic basis of frost tolerance (FT) in wheat (Triticum aestivum L.) is essential for preventing yield losses caused by frost due to cellular damage, dehydration and reduced metabolism. FT is a complex trait regulated by a number of genes and several gene families. Availability of the wheat genomic sequence opens new opportunities for exploring candidate genes diversity for FT.
24p
vibeauty
23-10-2021
13
1
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The deubiquitinase (DUB) family constitutes a group of proteases that regulate the stability or reverse the ubiquitination of many proteins in the cell. These enzymes participate in cell-cycle regulation, cell division and differentiation, diverse physiological activities such as DNA damage repair, growth and development, and response to stress.
16p
vijeeni2711
24-07-2021
15
0
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Insect pests that damage Dai Loan mango trees were preliminarily surveyed in some regions in Cao Lanh city, Dong Thap Province, Vietnam. The results of the survey recorded twenty-nine species of insect pests belonging to sixteen families, and fi ve orders. Bactrocera dorsalis (fruit fly), Idioscopus nitidulus (leafhopper) and Deanolis albizonalis (fruit borer) were very abundant, while Alcidodes frenatus had the lowest numbers in all surveyed sites.
9p
nguaconbaynhay12
03-06-2021
12
1
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Banana (Musa paradisiaca) is herbaceous plant belonging to the family Musaceae of the genus Musa and is native to the tropical region of South East Asia. Viral diseases have been causing considerable damage to banana production in banana growing areas due to their systemic invasion and common spread through vegetatively propagated planting materials.
6p
trinhthamhodang1218
26-02-2021
11
2
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Viral diseases cause greatest economic damage to the tomato crop among them Tospovirus belonging to the family of Bunyaviridae causes devastating diseases to many economically important crops including tomato. Many plant species are known to synthesize proteins with antiviral properties. The genes encoding anti viral proteins (AVPs) have been isolated and cloned from many plants. The study was conducted on synthesis of engineered Bougainvillea antiviral gene and its expression in tomato plant.
9p
trinhthamhodang1215
23-09-2020
8
1
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Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic susceptibility to breast cancer, of which CHEK2 is a plausible candidate. CHEK2 encodes a checkpoint kinase, involved in response to DNA damage.
7p
vijennie2711
29-09-2020
9
1
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Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and in vivo efficacy of a new maltol derived molecule (maltonis), belonging to the family of molecules named hydroxypyrones.
14p
virose2711
25-09-2020
19
1
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Individual susceptibility to endogenous and/or exogenous DNA damage depends on DNA repair efficiency and can be evaluated using the comet assay with bleomycin as genotoxic agent. The aim of the study was to evaluate baseline and bleomycin-induced DNA damage and DNA repair capacity in peripheral blood lymphocytes (PBLs) of endometrial cancer (EC) patients considering a family history of cancer.
6p
vilisa271
22-09-2020
15
0
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MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. Synthetic lethality provides an opportunity for therapeutic intervention of MYC-driven cancers.
13p
vialabama2711
21-09-2020
7
1
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BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susceptibility in high-risk Finnish hereditary breast and ovarian cancer (HBOC) families. EMSY is located in the breast cancerassociated chromosomal region 11q13.
8p
vidhaka2711
31-07-2020
10
1
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