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Degree of blockiness
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Pectins have anti-inflammatory effects via Toll-like receptor (TLR) inhibition in a degree of methyl-esterification- (DM)-dependent manner. However, pectins also vary in distribution of methyl-esters over the galacturonic-acid (GalA) backbone (Degree of Blockiness - DB) and impact of this on anti-inflammatory capacity is unknown.
11p
viginny
30-12-2022
9
2
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Citrus pectins were studied by enzymatic fingerprinting using a simultaneous enzyme treatment with endopolygalacturonase (endo-PG) from Kluyveromyces fragilis and pectin lyase (PL) from Aspergillus niger to reveal the methyl-ester distribution patterns over the pectin backbone.
8p
viginny
30-12-2022
11
2
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These structure-dependent effects could derive from induced shifts in microbiota composition that differed between DM18(low-DB) pectin and the other pectins. T-cell-modulating effects were not short-chain-fatty aciddependent, but rather through an increase in Aryl-hydrocarbon-receptor-activating components.
12p
viginny
30-12-2022
7
2
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