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Demonstrate toxicity
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Ebook "Major impacts and plate tectonics: A model for the Phanerozoic evolution of the Earth’s lithosphere" presents evidence to show that impacts can cause significant and dramatic changes in track, which cannot be explained by current theories of plate tectonics. The book also demonstrates that such major impact events often coincide with the development of continental flood basalts and oceanic plateau basalts and frequently coincide with major stratigraphic stage boundaries and toxicity, which in turn can be associated with periods of extinction.
358p
duongthandue0501
28-02-2024
2
1
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Oxaliplatin is a chemotherapeutic agent with direct toxic action on deoxyribonucleic acid (DNA), which is known to cause an arrest in its synthesis and inducing cell death. It is a crucial medication for colorectal carcinoma, and in combination with other medications has demonstrated to exhibit synergism, managing to increase patients’ survival, especially when compared to monotherapy with 5-fluoracil.
3p
viintuit
26-09-2023
4
0
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The Camellia tamdaoensis Hakoda et Ninh contains many useful phenolic compounds for human health, among them, flavonoids showed many biological activities such as antibacterial, antiinflammatory. In this study, we used the recovery extract method to collect concentrated solutions with high flavonoid content from golden tea leaves, in which ethanol served as solvents at the temperature of 70°C for 1 hour.
9p
viberkshire
09-08-2023
7
2
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Populations of the earthworm, Lumbricus rubellus, are commonly found across highly contaminated former mine sites and are considered to have under-gone selection for mitigating metal toxicity. Comparison of adapted populations with those found on less contaminated soils can provide insights into ecological processes that demonstrate the long-term effects of soil contamination.
13p
vinarcissa
21-03-2023
1
1
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The purpose of this study was to determine if commercially available adamantane carboxylic acids act by mitrochondrial mechanisms similar to NAs found in OSPW. Mitochondria isolated from rainbow trout (Oncorhynchus mykiss) liver were exposed to commercially available adamantane acids, 3-hydroxyadamantane-1-carboxylic acid (CAS 42711-75-1) and 3,5-dimethyladamantane-1-carboxylic acid (CAS 14670-94-1), or to NAs extracted and purified from OSPW.
5p
thebadguys
15-01-2022
11
0
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Safety and efficacy of immune checkpoint inhibitors in advanced gastric or gastroesophageal junction (GEJ) cancer could be demonstrated in predominantly Asian cohorts, whereas data in Western patients outside of clinical trials are vastly missing.
10p
vielonmusk
21-01-2022
16
0
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The biocomposite demonstrated upgraded swelling and antibacterial activity. The addition of ZnHAP accomplished the antibacterial activity. Biocompatibility studies were carried out using osteoblast cells and thus we proved the non-toxic nature of the biocomposite. Osteoblast cell adhesion investigations demonstrated that the cells were appended and infiltrated into the inside of the biocomposite.
5p
meyerowitz
25-12-2021
5
0
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The evidence for a complete cellular remnant removal was shown through Hematoxylin and Eosin staining and DNA measurements. The AAM powder was prepared by mechanical disruption under reduced temperatures, which resulted in an AAM particle size in the range of 100 mm. In vitro cytotoxicity testing via extraction demonstrated that AAM had no toxicity on human adipose derived stem cells (hADSCs).
10p
meyerowitz
25-12-2021
9
0
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To evaluate the efficacy and safety of recombinant human serum albumin /granulocyte colonystimulating factor (rHSA/G-CSF) in breast cancer following receipt of cytotoxic agents. The prospective randomized controlled trials demonstrated that rHSA/G-CSF was efficacious and welltolerated with an approachable frequency and expense of application for prophylactic management of agranulocytosis.
11p
vianrose2711
27-04-2021
11
2
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Active vitamin D analogs that are less toxic than calcitriol can be useful in the combined treatment of patients suffering from colon cancer. In the present study we demonstrate, for the first time in an in vivo model system, the biological effect of combined therapy using 5-fluorouracil (5-FU) along with vitamin D analog PRI-2191 (tacalcitol, 1,24-dihydroxyvitamin D3) or PRI-2205 (5,6-trans-isomer of calcipotriol) on colon cancer.
19p
vijennie2711
29-09-2020
9
1
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Excellent dosimetric characteristics were demonstrated for volumetric modulated arc therapy (VMAT) in preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). In a single-center retrospective analysis, we tested whether these advantages may translate into significant clinical benefits.
8p
vimoscow2711
29-08-2020
21
2
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The natural compound triptolide has been shown to decrease cell proliferation and induce apoptosis and cellular senescence. We previously demonstrated that triptolide decreases tumor formation and metastasis of human non-small cell lung cancer cells (NSCLC). Due to the toxicity of triptolide, derivatives of the natural compound have been developed that show more favorable toxicity profiles and pharmacokinetics in animal models.
10p
vinaypyidaw2711
26-08-2020
9
2
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Alpha-tocopheryloxyacetic acid (α-TEA) is a semi-synthetic derivative of naturally occurring vitamin E (alpha-tocopherol) that can be delivered via an oral route. Preclinical in vitro and in vivo data demonstrated that α-TEA is a potent anti-tumor agent with a safe toxicity profile in mice.
16p
vinaypyidaw2711
26-08-2020
12
2
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No novel chemotherapeutic combinations have demonstrated superior efficacy to etoposide/cisplatin (EP), a standard treatment regimen for extensive-stage small cell lung carcinoma (ES-SCLC) over the past decade.
9p
vimale2711
25-08-2020
9
1
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Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/ bevacizumab compared with paclitaxel/bevacizumab.
8p
vimale2711
25-08-2020
5
1
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We designed a single-arm, open-label phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy. The study did not meet its primary objective of demonstrating the anti-tumor activity of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy.
6p
vimale2711
21-08-2020
18
2
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Prospective trials have demonstrated the advantage of dose-escalated radiotherapy for the biochemical and clinical control of intermediate risk prostate cancer. Dose escalation improves outcomes but increases risks of urinary and bowel toxicity.
6p
vibaku2711
22-07-2020
8
1
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Poly (ADP-ribose) Polymerase (PARP) inhibitors are promising novel radiosensitisers. Pre-clinical models have demonstrated potent and tumour-specific radiosensitisation by PARP inhibitors.
13p
vikuala271
13-06-2020
5
1
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Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free hemoglobin (Hb). Proof of concept studies have demonstrated efficacy of Hp in hemolysis associated with transfusion and sickle cell anemia.
13p
vihamax2711
21-04-2020
13
1
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Platinum derivatives are used widely for the treatment of many cancers. However, the toxicity that is observed makes imperative the need for new drugs, or new combinations. Anvirzel™ is an extract which has been demonstrated with experimental data that displays anticancer activity.
6p
vienzym2711
03-04-2020
13
1
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