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Dependent modifications of chromatin
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DNA methylation is an epigenetic modification that mainly repress expression of genes essential during embryogenesis and development. There are key ATPase-dependent enzymes that read or write DNA methylation to remodel chromatin and regulate gene expression.
10p
vihagrid
30-01-2023
7
3
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A cell’s epigenome arises from interactions among regulatory factors—transcription factors and histone modifications—co-localized at particular genomic regions. We developed a novel statistical method, ChromNet, to infer a network of these interactions, the chromatin network, by inferring conditional-dependence relationships among a large number of ChIP-seq data sets.
19p
viaristotle
29-01-2022
8
0
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Chromatin modifications such as DNA methylation are targeted to transposable elements by small RNAs in a process termed RNA-directed DNA methylation (RdDM). In plants, canonical RdDM functions through RNA polymerase IV to reinforce pre-existing transposable element silencing.
19p
viaristotle
29-01-2022
5
0
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Regulation of transcription depends on interactions between cis-regulatory elements (CREs) and regulatory proteins. Active CREs are imbedded in open chromatin that are accessible to nucleases. Several techniques, including DNase-seq, which is based on nuclease DNase I, and ATAC-seq, which is based on transposase Tn5, have been widely used to identify genomic regions associated with open chromatin
17p
viarchimedes
26-01-2022
10
0
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Chromatin immunoprecipitation coupled with hybridization to a tiling array (ChIP-chip) is a cost-effective and routinely used method to identify protein-DNA interactions or chromatin/histone modifications. The robust identification of ChIP-enriched regions is frequently complicated by noisy measurements.
5p
viwyoming2711
16-12-2020
14
1
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Chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) and associated methods are widely used to define the genome wide distribution of chromatin associated proteins, post-translational epigenetic marks, and modifications found on DNA bases.
16p
viconnecticut2711
29-10-2020
15
2
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Observed levels of gene expression strongly depend on both activity of DNA binding transcription factors (TFs) and chromatin state through different histone modifications (HMs). In order to recover the functional relationship between local chromatin state, TF binding and observed levels of gene expression, regression methods have proven to be useful tools.
13p
vicolorado2711
23-10-2020
46
1
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DNA replication and transcription are dynamic processes regulating plant development that are dependent on the chromatin accessibility. Proteins belonging to the Agenet/Tudor domain family are known as histone modification “readers” and classified as chromatin remodeling proteins.
21p
vihashirama2711
21-05-2020
10
2
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(bq) part 2 book "handbook of vitamins" has contents: pantothenic acid, vitamin b6, biotin, folic acid, vitamin b12, choline, vitamin - dependent modifications of chromatin - epigenetic events and genomic stability, dietary reference intakes for vitamins.
306p
bautroibinhyen18
21-02-2017
53
8
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(bq) part 2 book "handbook of vitamins" has contents: vitamin b6, biotin, folic acid, vitamin b12, choline, vitamin - dependent modifications of chromatin - epigenetic events and genomic stability, dietary reference intakes for vitamins.
263p
bautroibinhyen18
21-02-2017
50
6
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Some limited understanding of self-renewal exists and, intriguingly, implicates gene products that are associated with the chromatin state, a high-order organization of chromosomal DNA that influences transcription. These include members of the polycomb family, a group of zinc finger–containing transcriptional regulators that interact with the chromatin structure, contributing to the accessibility of groups of genes for transcription.
6p
konheokonmummim
03-12-2010
79
4
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