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Descending modulation
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Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold.
14p
vienzym2711
03-04-2020
11
3
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In the past decade several studies have reported that in some brain areas, particularly, in the midbrain periaqueductal gray matter, rostral ventro-medial medulla, central nucleus of amygdala, nucleus raphe magnus, and dorsal hippocampus, microinjections of non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception with distinct development of tolerance.
7p
vimax2711
30-03-2020
11
1
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Drugs for the Suppression of Pain (Analgesics) ing, or burning character, i.e., pain that can be localized only poorly. Impulse traffic in the neo- and paleospinothalamic pathways is subject to modulation by descending projections that originate from the reticular formation and terminate at second-order neurons, at their synapses with first-order neurons, or at spinal segmental interneurons (descending antinociceptive system).
10p
bigbaby87
04-09-2010
88
15
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