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Desmoplastic small round cell tumor
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Desmoplastic small round cell tumor is a rare malignancy with poor prognosis, affecting young male patients. It frequently presents as a large abdominal mass with widespread peritoneal involvement at diagnosis. In late stages, metastases may be present.
6p
vilazada
31-01-2024
4
2
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Single-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell level. Classification of bulk tumors by their individual cel‑ lular constituents has also created new opportunities to generate single-cell atlases for many organs, cancers, and developmental models.
16p
visharma
20-10-2023
4
2
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Desmoplastic small round cell tumor (DSRCT) is characterized by the presence of a fusion protein EWS/WT1, arising from the t (11;22) (p13;q12) translocation. Here we examine the oncogenic properties of two splice variants of EWS/WT1, EWS/WT1-KTS and EWS/WT1 + KTS.
14p
vijennie2711
29-09-2020
15
1
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Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive disease, that can be described as a member of the family of small round blue cell tumors. The molecular diagnostic marker is the t(11; 22)(p13;q12) translocation, which creates an aberrant transcription factor, EWS-WT1, that underlies the oncogenesis of DSRCT.
9p
vimale2711
21-08-2020
9
1
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Desmoplastic small round cell tumor (DSRCT) is a rare malignant sarcoma with poor prognosis due to lack of effective treatments. Apatinib is a new potent oral small-molecule tyrosine kinase inhibitor, and targets the intracellular domain of vascular endothelial growth factor receptor 2 (VEGFR-2).
6p
vibaku2711
22-07-2020
10
0
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Desmoplastic small round cell tumor (DSRCT) is a rare malignancy with poor prognosis that generally involves the peritoneum. Its diagnosis can be achieved only by immunohistochemistry and cytogenetic studies.
5p
vikuala271
13-06-2020
10
1
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Table 79-3 Representative Oncogenes at Chromosomal Translocations Gene (Chromosome) Translocation Malignancy ABL BCR (22q11) (9q34.1)– (9;22)(q34;q11) Chronic myelogenous leukemia ATF1 EWS (22q12) (12q13)– (12;22)(q13;q12) Malignant melanoma of soft parts (MMSP) BCL1 IgH (14q32) (11q13.3)– (11;14)(q13;q32) Mantle lymphoma cell BCL2 IgH (14q32) (18q21.
5p
konheokonmummim
03-12-2010
66
3
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