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Despite extensive
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This paper presents an enriched variation of the original Vehicle Routing Problem (VRP), in which traffic zones, CO2 emissions and heterogeneity of vehicles are all taken into consideration. Despite the extensive research already focused at VRP, its applicability in Supply Chain Management, has pushed researchers in investigating richer, and more realistic versions of VRP with various business constraints.
12p
longtimenosee07
29-03-2024
2
2
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Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive.
21p
vioraclene
31-03-2024
2
2
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Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in prostate cancer metastasis, the emergence and evolution of cancer clones at this early stage of expansion and spread are poorly understood.
18p
vicwell
29-02-2024
2
1
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Probiotics are gaining increasing attention due to their significant benefits to the host. Despite their potential advantages, probiotic dosage forms have not been extensively studied, primarily because of their poor survival through the gastrointestinal tract. Probiotic tablets emerge as a promising delivery system utilized in nutritional products to supplement the natural intestinal flora.
9p
vimichaelfaraday
28-12-2023
7
3
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Despite the extensive use of thin-walled structures, the studies on their behaviours when exposed to extreme thermal environment are relatively scarce. Therefore, this paper aims to present the buckling analysis of thin-walled composite I-beams under thermo-mechanical loads. The thermal effects are investigated for the case of studied beams undergoing a uniform temperature rise through their thickness.
16p
viwolverine
11-07-2023
4
3
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Gadolinium-based contrast agents are used extensively in magnetic resonance imaging to assist diagnosis of medical conditions. Despite their documented safety profile, severe adverse events do occur, and their documentation may serve to raise the awareness of the medical community.
4p
videadpool
05-05-2023
7
2
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Ritodrine, a tocolytic β2-agonist, has been used extensively in Europe and Asia despite its safety concerns. This study was designed to identify associations between β2-adrenergic receptor (ADRB2) polymorphisms and adverse drug events (ADEs) in patients with preterm labor treated with ritodrine.
6p
vinarcissa
21-03-2023
2
1
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Despite extensive research the genetic component of extremely low birth weight (ELBW) in newborns has remained obscure. A family of four was studied: mother, father and two ELBW-phenotype children. Studies were made of the medical conditions of the second child at birth and post-partum - peculiar phenotype, micro-anomalies, recurrent infections, suspicion of autoimmune hepatitis, multifactorial encephalopathy and suspected metabolic and chromosomal abnormalities.
5p
vinarcissa
21-03-2023
6
1
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Despite extensive research, the debate continues as to the optimal way of guiding intraoperative and postoperative fluid therapy. In 2009 we changed our institutional guideline for perioperative fluid therapy in patients undergoing extrapleural pneumonectomy (EPP) and implemented the use of central venous oxygen saturation and intended low urine output to guide therapy in the early postoperative period. Here we evaluate the consequences of our changes.
7p
viisaacnewton
25-04-2022
6
1
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The management of neuropathic pain (NP) is challenging despite it being the recent focus of extensive research. A number of clinical practice guidelines (CPGs) for the management of NP have been published worldwide over the past 2 decades. This study aimed to assess the quality of these CPGs.
10p
viisaacnewton
25-04-2022
9
1
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Fluid management in the perioperative period has been extensively studied but, despite that, “the right amount” still remains uncertain. The purpose of this paper is to summarize the state of the art of intraoperative fluid approach today.
8p
viisaacnewton
26-04-2022
6
1
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Ten-eleven translocation (TET) enzymes oxidise DNA methylation as part of an active demethylation pathway. Despite extensive research into the role of TETs in genome regulation, little is known about their effect on transposable elements (TEs), which make up nearly half of the mouse and human genomes.
14p
vialfrednobel
29-01-2022
2
0
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Despite extensive pharmacological approaches, there is no curative therapy for Alzheimer’s disease (AD) or other types of dementias. While current pharmacological options alleviate some symptoms of AD, they can lead to various adverse effects. Hence, nonpharmacological treatment options for AD are often considered with the assumption that they are safe, effective, and economic in managing patients.
9p
dolomite36
30-12-2021
12
0
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The association between obesity and breast cancer (BC) has been extensively studied among US, European and Asian study populations, with often conflicting evidence. However, despite the increasing prevalence of obesity and associated conditions in Africa, the continent with the highest age-standardized BC mortality rate globally, few studies have evaluated this association, and none has examined in relation to molecular subtypes among African women.
13p
vimahuateng
26-11-2021
8
1
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Whole genome re-sequencing data from dogs and wolves are now commonly used to study how natural and artificial selection have shaped the patterns of genetic diversity. Single nucleotide polymorphisms, microsatellites and variants in mitochondrial DNA have been interrogated for links to specific phenotypes or signals of domestication. However, copy number variation (CNV), despite its increasingly recognized importance as a contributor to phenotypic diversity, has not been extensively explored in canids.
15p
vilarryellison
29-10-2021
6
1
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Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided into six discrete typing units (DTUs), named TcI-TcVI. TcII is among the major DTUs enrolled in human infections in South America southern cone, where it is associated with severe cardiac and digestive symptoms. Despite the importance of TcII in Chagas disease epidemiology and pathology, so far, no genome-wide comparisons of the mitochondrial and nuclear genomes of TcII field isolates have been performed to track the variability and evolution of this DTU in endemic regions.
17p
vitzuyu2711
29-09-2021
9
1
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Despite a growing number of investigations on early diverging fungi, the corresponding lineages have not been as extensively characterized as Ascomycota or Basidiomycota ones. The Mucor genus, pertaining to one of these lineages is not an exception.
21p
vijeeni2711
24-07-2021
10
1
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The genus Brassica mainly comprises three diploid and three recently derived allotetraploid species, most of which are highly important vegetable, oil or ornamental crops cultivated worldwide. Despite being extensively studied, the origination of B. napus and certain detailed interspecific relationships within Brassica genus remains undetermined and somewhere confused.
15p
vijeeni2711
24-07-2021
14
0
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TIFY is a plant-specific protein family with a diversity of functions in plant development and responses to stress and hormones, which contains JASMONATE ZIM-domain (JAZ), TIFY, PPD and ZML subfamilies. Despite extensive studies of TIFY family in many other species, TIFY has not yet been characterized in Brassica napus.
13p
vijeeni2711
30-06-2021
17
1
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Through rigorous rural electrification projects, over 99.97% of Bhutan’s households now have access to electricity, which is predominantly generated from run-of-the-river hydropower plants. Despite this achievement, around 5% of the rural households still do not have access to electricity to meet their cooking load demands and, therefore, they extensively rely on firewood, LPG, and kerosene for cooking purposes. Apart from hydropower, penetration of other renewable sources such as solar and wind power in the country is negligible.
9p
caygaocaolon11
18-04-2021
19
1
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