Despite improvements
-
Indigenous adolescents access primary health care services at lower rates, despite their greater health needs and experience of disadvantage. This systematic review identifies the enablers and barriers to primary health care access for Indigenous adolescents to inform service and policy improvements.
29p vishanshan 27-06-2024 1 1 Download
-
Smoking is a major risk factor for multiple gastrointestinal cancers, and adversely affects peptic ulcer disease, gastroesophageal reflux, pancreatitis and Crohn’s disease. Despite key recommendations for diagnosing and treating tobacco use disorder in healthcare settings, the degree to which this is implemented in Gastroenterology (GI) clinics is unknown.
10p vishanshan 27-06-2024 1 1 Download
-
Despite the many interventions that have been implemented in sub-Saharan Africa to improve the uptake of HIV testing and antiretroviral (ART) initiation services, the rates at which men are tested for HIV and initiated on ART have remained consistently lower compared to those for women.
8p vishanshan 27-06-2024 1 1 Download
-
Despite recent improvements in cancer detection and survival rates, managing cancer-related pain remains a significant challenge. The objective of this work was to select a panel of biomarkers of central pain processing and modulation and assess their ability to predict chronic pain in patients with cancer using predictive artificial intelligence (AI) algorithms.
11p vikoch 27-06-2024 1 1 Download
-
Tumor Treating Fields (TTFields) Therapy is an FDA-approved therapy in the first line and recurrent setting for glioblastoma. Despite Phase 3 evidence showing improved survival with TTFields, it is not uniformly utilized. We aimed to examine patient and clinician views of TTFields and factors shaping utilization of TTFields through a unique research partnership with medical neuro oncology and medical social sciences.
11p vikoch 27-06-2024 1 1 Download
-
Despite some therapeutic advances, improvement in survival rates of unresectable and/or metastatic pancreatic ductal adenocarcinoma (PDAC) has been minimal over recent decade. We aimed to evaluate the impact of different treatment sequences on clinical outcomes of advanced PDAC at our academic institution.
11p vikoch 27-06-2024 1 1 Download
-
Pediatric kidney transplants has been increasing in recent years, as the procedure provides long-lasting and favorable outcomes; however many complications can occur in post-transplant period. The early perioperative care plays a significant role in reducing complications and improving the quality of treatment. Objectives: To describe the clinical, laboratory, and early complications in perioperative period post kidney transplant surgery.
7p vicarlos 11-06-2024 0 0 Download
-
The last few years have seen an exponential increase in the significance of the environmental agenda at the global level. Despite decades of research, the motivations that drive managers to engage in sustainable green practices remained uncertain. This study examines the degree to which value-belief-norm framework in explaining engagement in sustainable green practices. The data for this study was collected from 260 manufacturing SMEs and was analyzed by employing Structural Equation Modelling.
6p longtimenosee10 26-04-2024 2 1 Download
-
Precision public health is a relatively new field that integrates components of precision medicine, such as human genomics research, with public health concepts to help improve population health. Despite interest in advancing precision public health initiatives using human genomics research, current and future opportunities in this emerging field remain largely undescribed.
10p vibransone 28-03-2024 5 2 Download
-
Ebook "Reducing drug attrition (Topics in Medicinal chemistry, Volume 11)" is to provide guidance to those persons who are dedicated to the creation and development of new drugs to aid patients. Our aim was to address the key factors that have led to failure of preclinical and clinical drug candidates. Despite the significant scientific advances over the past few decades in the disciplines associated with research and development (R&D), the overall productivity, as measured by new approved drugs, has not improved.
176p tudohanhtau1006 29-03-2024 1 1 Download
-
Ebook "Advances in biology and therapy of multiple myeloma - Volume 1: Basic science" despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.
322p duongthandue0501 28-02-2024 3 1 Download
-
Disparities in cardiovascular outcomes between Māori and non-Māori persist despite technological advances in the treatment of cardiovascular disease and improved service provision. This paper explores the contexts within which cardiovascular disease is experienced and healthcare becomes embedded.
8p vitiki 30-01-2024 2 2 Download
-
Ebook "Biotechnology of crucifers" despite the recent advances made in the improvement of crucifer crops using conventional breeding techniques, the yield levels and the oil and meal quality could not be improved as expected. The understanding of genetic material (DNA/RNA) and its manipulation by scientists has provided the opportunity to improve crucifers by increasing its diversity beyond conventional genetic limitations.
249p lucchinguyen 28-12-2023 5 2 Download
-
Despite the poor prognosis of triple-negative breast cancer (TNBC), it has been demonstrated that neoadjuvant immunotherapy in combination with chemotherapy can improve the pathologic complete response (pCR) rate and/or long-term outcome of TNBC. However, there have been no real-world studies reporting on the efectiveness of neoadjuvant checkpoint inhibitors in early TNBC.
9p vileonardodavinci 23-12-2023 8 2 Download
-
Despite the diverse genetic mutations in head and neck cancer, the chemotherapy outcome for this cancer has not improved for decades. It is urgent to select prognostic factors and therapeutic targets for oropharyngeal cancer to establish precision medicine.
9p vileonardodavinci 23-12-2023 3 2 Download
-
Glioblastoma (GBM) is the most aggressive type of brain tumor with heterogeneity and strong invasive ability. Treatment of GBM has not improved significantly despite the progress of immunotherapy and classical therapy. Epidermal growth factor receptor variant III (EGFRvIII), one of GBM-associated mutants, is regarded as an ideal therapeutic target in EGFRvIII-expressed GBM patients because it is a tumor-specific receptor expressed only in tumors.
11p vialfrednobel 23-12-2023 3 3 Download
-
Osteosarcoma is the most common primary bone cancer that affects mostly children and young adults. Despite the advances in osteosarcoma treatment, the long-term survival rate of metastatic patients has not significantly improved in the past few decades, thus demonstrating the need for novel therapeutic targets or methods to improve metastatic osteosarcoma treatment.
16p vialfrednobel 23-12-2023 4 4 Download
-
Adjuvant therapies such as radiation therapy, chemotherapy, and immunotherapy are usually given after cancer surgery to improve the survival of cancer patients. However, despite advances in several adjuvant thera‑ pies, they are still limited in the prevention of recurrences.
12p vialfrednobel 23-12-2023 3 3 Download
-
Prostate cancer patients with locoregional lymph node disease at diagnosis (N1M0) still have a limited prognosis despite the improvements provided by aggressive curative intent multimodal locoregional external beam radiation therapy (EBRT) with systemic androgen deprivation therapy (ADT).
13p vischultz 20-10-2023 4 1 Download
-
Current treatment of acute leukemia is based on anthracycline chemotherapy. Anthracyclines, despite improving patient survival, have serious cardiotoxicity and therefore cardiac monitoring should be a priority.
9p visharma 20-10-2023 5 2 Download