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Destructive disease
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Cancer is the most destructive and fatal disease, representing an urgent medical challenge to the world. The discovery of a new anticancer candidate may help reduce or eliminate this alarming disease to a greater extent. On similar lines, in silico research was carried out on novel naphthylidene isoxazolidinedione derivatives that were logically conceived, synthesized, purified, and structurally characterized. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells.
10p
dianmotminh02
03-05-2024
4
1
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The article would like to introduce a psoriatic arthritis (PsA) patient in the Department of Rheumatology of 108 Military Central Hospital. This case of PsA had the secondary tuberculosis infection after Tumor necrotic factor inhibitor (TNFi) treatment, nevertheless the articular destruction caused by PsA still went on.
6p
vishekhar
01-11-2023
2
0
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Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, resulting in destruction and deformation of bones and cartilage. This study describes hematological characteristics and the relationship of RPR and HPR indices with inflammation in patients with RA.
6p
vischultz
17-10-2023
4
2
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Stem end rot is the most destructive disease caused by Alternaria alternata YZU in pitayagrowing regions of Vietnam. This study was conducted to characterize antagonistic phosphatesolubilizing bacteria (PSB) from rhizosphere soil for their biocontrol activities against A. alternata YZU and evaluate the effect of temperature, pH, and water activity on that antagonism.
8p
vispiderman
15-06-2023
9
1
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Progressive multifocal leukoencephalopathy is a rare demyelinating disease that is often secondary to lytic destruction of oligodendrocytes and, to a lesser extent, to astrocytes’ response to human neurotrophic John Cunningham polyomavirus.
5p
vigamora
23-05-2023
3
2
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CRISPR/Cas has recently been transferred to plants to make them resistant to geminiviruses, a damaging family of DNA viruses. We discuss the potential and the limitations of this method.
4p
viaristotle
29-01-2022
7
0
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This study aimed to detect the gray mold disease at an early stage on tomato fruits using the non-destructive visible/near-infrared (VIS/NIR) technique. Botrytis. cinerea fungus was isolated and identified using two specific primer sets (C729+/- and BC108+/BC563-). Three tomato varieties were used for this study (i.e. Harver, Izmer and Ekram), 30 samples from each variety, 20 samples were injected with the B. cinerea and 10 samples were left as control/healthy samples.
5p
mudbound
10-12-2021
22
1
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Leaf blight caused by Calonectria spp. is one of the most destructive diseases to affect Eucalyptus nurseries and plantations. These pathogens mainly attack Eucalyptus, a tree with a diversity of secondary metabolites employed as defense-related phytoalexins. To unravel the fungal adaptive mechanisms to various phytoalexins, we examined the genome of C. pseudoreteaudii, which is one of the most aggressive pathogens in southeast Asia.
12p
vibeauty
23-10-2021
17
1
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Bananas (Musa spp.) are the most important fruit crops worldwide due to their high nutrition value. Fusarium wilt of banana, caused by fungal pathogen Fusarium oxysporum f. sp. cubense tropical race 4 (Foc 4), is considered as the most destructive disease in the world and results in extensive damage leading to productivity loss. The widespread use of plant resistance inducers (PRIs), such as benzothiadiazole (BTH), is a novel strategy to stimulate defense responses in banana plants to protect against pathogens infection.
19p
vibeauty
23-10-2021
20
1
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The Ceratocystis genus harbors a large number of phytopathogenic fungi that cause xylem parenchyma degradation and vascular destruction on a broad range of economically important plants. Ceratocystis cacaofunesta is a necrotrophic fungus responsible for lethal wilt disease in cacao. The aim of this work is to analyze the genome of C. cacaofunesta through a comparative approach with genomes of other Sordariomycetes in order to better understand the molecular basis of pathogenicity in the Ceratocystis genus.
24p
vibeauty
23-10-2021
4
1
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Ascochyta blight, caused by the fungus Ascochyta lentis, is one of the most destructive lentil diseases worldwide, resulting in over $16 million AUD annual loss in Australia alone. The use of resistant cultivars is currently considered the most effective and environmentally sustainable strategy to control this disease. However, little is known about the genes and molecular mechanisms underlying lentil resistance against A. lentis.
21p
vibeauty
23-10-2021
6
0
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JWB phytoplasma is a kind of insect-transmitted and uncultivable bacterial plant pathogen causeing a destructive Jujube disease. To date, no genome information about JWB phytoplasma has been published, which hindered its characterization at genomic level.
12p
vitzuyu2711
29-09-2021
15
1
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Monochamus alternatus Hope is one of the insect vectors of pinewood nematode (Bursaphelenchus xylophilus), which causes the destructive pine wilt disease. The microorganisms within the ecosystem, comprising plants, their environment, and insect vectors, form complex networks.
13p
vijeeni2711
24-07-2021
4
0
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Sesame (Sesamum indicum) charcoal rot, a destructive fungal disease caused by Macrophomina phaseolina (Tassi) Goid (MP), is a great threat to the yield and quality of sesame. However, there is a lack of information about the gene-for-gene relationship between sesame and MP, and the molecular mechanism behind the interaction is not yet clear.
21p
vijichea2711
28-05-2021
7
1
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Transbronchial lung biopsy (TBLB) in the diagnosis of lymphangioleiomyomatosis (LAM) is not a com‑ mon approach, although TBLB is often performed in diffuse lung diseases. We aimed to examine the diagnostic value and safety of TBLB in LAM patients based on the data collected in our center.
6p
vijichoo2711
31-05-2021
9
1
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Verticillium wilt is a widespread and destructive disease, which causes serious loss of cotton yield and quality. Long non-coding RNA (lncRNA) is involved in many biological processes, such as plant disease resistance response, through a variety of regulatory mechanisms, but their possible roles in cotton against Verticillium dahliae infection remain largely unclear.
13p
vijichea2711
28-05-2021
11
1
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Tomato (Lycopersicon esculentum Mill.) is the most popular vegetable grown across the world. Wilt disease caused by the fungus Fusarium oxysporum f.sp. lycopersici is one of the most devastating and destructive disease of tomato, resulting in significant yield loss. The pathogen causing wilt disease in tomato was isolated and confirmed its pathogenicity in glasshouse experiment. The effect of fungal biocontrol agent Chaetomium spp. was studied against fusarium wilt pathogen under in vitro condition. Among the Chaetomium spp., Ch. cochiloides showed highest inhibition percentage of 64.
11p
caygaocaolon11
21-04-2021
12
1
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Osteoporosis is a well-known extra articular manifestation in rheumatoid arthritis (RA). Biologic disease modifying anti rheumatic drugs (DMARDs) has been shown to be superior to synthetic DMARDs to reduce bone destruction including generalized bone loss in RA.
9p
viannito2711
20-04-2021
9
2
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Rheumatoid arthritis (RA) is a chronic autoinflammatory joint disease which leads to the destruction of joints and disability of the patients. Anti-tumour necrosis factor (anti-TNF) drugs can halt radiological progression better than conventional DMARDs even in clinical non-responders.
7p
viannito2711
20-04-2021
14
2
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To evaluate a combined rheumatoid arthritis magnetic resonance imaging score (RAMRIS) for hand and foot (HaF-score) in rheumatoid arthritis (RA). The HaF-score identifies patients with continuing disease activity despite clinical response that would have been missed by consideration of the traditional RAMRIS or the DAS28 alone.
8p
viannito2711
20-04-2021
10
2
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