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Detection of rifampicin resistance
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Drug-resistant Tuberculosis (DR-TB) is challenging public health problem in countries with high tuberculosis prevalence and limited resources. Developing and applying the most appropriate and effective methods for diagnosing DR-TB from clinical samples is necessary, allowing a more rapid detection method for large-scale screening.
7p
viwolverine
07-07-2023
3
1
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Drug resistant tuberculosis (DR-TB) remains a global health problem. The diagnosis, treatment, and management of DR-TB are the major challenges to Vietnam National Tuberculosis Control Program. One of the most important solutions for overcoming this problem is developing reliable and low-cost methods, which have been proposed to Drug Susceptibility Testing (DST) to detect drug resistant tuberculosis. The methods have to be reasonably simple so that they can be widely used in provincial Lung hospitals.
6p
cothumenhmong11
06-05-2021
22
2
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Tuberculosis remains as one of the leading cause of morbidity and mortality globally. Estimated cases of around 9.6 million are affected by all forms of TB worldwide, out of which 2.2 billion are affected in India. India also has the second highest burden of MDR TB after China. Information on MDR TB is sparse in Raichur District. We undertook this study to detect MDR TB among MDR suspected cases and its common mutation using Genotype MTBDR plus. All presumptive MDR sputum samples were sent to DST LAB RIMS, Raichur from various part of Raichur district.
7p
gaocaolon9
22-12-2020
13
1
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Tuberculosis is a major public health problem and second largest cause of death among infectious diseases. Rapid diagnosis of tuberculosis and detection of drug resistance is essential for effective disease control.
7p
quenchua8
29-09-2020
12
0
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Drug-resistance is a growing threat to global efforts in controlling and managing TB infections. Drug-susceptible TB is curable but drug misuse and poor patient compliance leads to multidrug resistance to the first line of TB antibiotics, rifampicin and isoniazid. The second line of treatment is less potent and has severe side effects, takes longer to cure the disease, and has poor success rates (Gandhi et al., 2010).
4p
nguaconbaynhay6
23-06-2020
12
1
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Tuberculosis is a major public health problem and second largest cause of death among infectious diseases. Rapid diagnosis of tuberculosis and detection of drug resistance is essential for effective disease control. Control of TB is hindered by the lack of a simple and effective diagnostic tool that can be utilised in resource limited settings. Molecular techniques using Real time PCR technology have gained momentum for rapid diagnosis and detection of drug resistance.
8p
caygaocaolon2
11-03-2020
16
1
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M. ulcerans is the etiologic agent of Buruli ulcer. The clinical diagnosis of infection with this mycobacterium is based on microbiological analyzes, including PCR, which uses the nucleotide sequences of the primers to detect the targeted sequences. Cases of rifampicin resistance were recorded in mice experimentally infected with M. ulcerans strains and treated with rifampicin in previous studies. In this study, clinical isolates were confirmed as M. ulcerans strains. These isolates are from samples of patients with Buruli ulcer. The PCR gave a positivity rate of 92.
7p
kethamoi2
15-12-2019
16
0
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India is high tuberculosis burdened country with increasing prevalence of multidrug resistant tuberculosis. Rapid diagnosis and prompt treatment of infectious cases are the key elements in reducing the spread of tuberculosis. In the present study we sought to ascertain multidrug resistant tuberculosis among previously treated tuberculosis cases and its resistance pattern to rifampicin and isoniazid genes.
7p
chauchaungayxua1
04-12-2019
35
1
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Tuberculosis (TB) is one of the world’s most important infectious causes of morbidity and mortality among adults. An estimated one-third of the world’s population is infected with TB. In 2010, there were 8.8 million new, and 12.0 million prevalent cases of TB; 1.1 million deaths occurred among HIV-uninfected people and an additional 0.35 million deaths among HIV-infected people (WHO 2011a). Of the total new TB cases, an estimated 12% to 14% occurred among people living with HIV. Approximately one million TB cases occur in children younger than 15 years old annually (Marais 2010a).
23p
taisaocothedung
12-01-2013
73
4
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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Clinical Microbiology đề tài: Low-cost rapid detection of rifampicin resistant tuberculosis using bacteriophage in Kampala, Uganda...
6p
thulanh9
08-10-2011
48
2
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