Detrimental effects
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Leptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly detrimental occurrence associated with severe neurological disorders, lacking effective treatment currently. Proteolysis-targeting chimeric molecules (PROTACs) may provide new therapeutic avenues for treatment of podophyllotoxin derivatives-resistant SCLC with LM, warranting further exploration.
12p vishanshan 27-06-2024 2 1 Download
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Neuropathic pain is common in cancer survivorship and is one of the most distressing symptoms for patients previously treated for head and neck cancer. Persistent neuropathic pain, when it is ongoing and uncontrolled, has a detrimental effect and erodes patients’ quality of life.
6p vileonardodavinci 23-12-2023 2 2 Download
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The psychological, physical and social effect of substance abuse is enormous and can be detrimental to the productive years of a youth. Researches have demonstrated that substance use often lead to negative psychological, physical and social impairment.
6p vikissinger 21-12-2023 7 2 Download
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Ebook "EU enlargement and its macroeconomic effects in Eastern Europe: Currencies, prices, investment and competitiveness" offers a detailed study of the macroeconomic and structural adjustment burden. It envisages a real currency appreciation stemming from price convergence, capital inflows and weak structural change. The widespread belief that an Eastern enlargement of the Union would be overwhelmingly to the detriment of the present EU (budgetary costs, locational decisions, trade deficits) is rejected.
252p loivantrinh 29-10-2023 5 3 Download
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Adjuvant endocrine treatment is essential for treating luminal subtypes of breast cancer, which constitute 75% of all breast malignancies. However, the detrimental side effects of treatment make it difficult for many patients to complete the guideline-required treatment.
12p vioracle 29-09-2023 6 3 Download
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Accurate prediction models for spatial prediction of forest fire danger play a vital role in predicting forest fires, which can help prevent and mitigate the detrimental effects of such disasters. This research aims to develop a new ensemble learning model, HHO-RSCDT, capable of accurately predicting spatial patterns of forest fire danger.
19p viisac 15-09-2023 3 3 Download
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Antibiotics administered incorrectly may result in detrimental consequences, such as prolonging treatment duration, causing adverse effects, or even increasing mortality. The research aimed to examine the characteristics of the antibiotics list utilized at PDHC in 2019.
7p viwarmachine 03-07-2023 3 2 Download
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Breast cancer is widely known as the most common cancer in women in the United States. If left untreated, it can have detrimental effects. If the breast cancer is aggressive in nature, it can metastasize to the lymph nodes, bones, liver, lungs, and brain. A rare location of metastasis is the leptomeninges, specifically the pia and arachnoid matter.
6p viwhitewolf 03-07-2023 4 2 Download
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We studied the impact of online social support on patient self-care behavior in an online health community for human immunodeficiency virus (HIV) patients. We conceptualized emotional and informational support provided by community members into nuanced sub-dimensions.
14p visteverogers 24-06-2023 4 2 Download
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The Australian music industry is growing and developing yet specific information about the ways in which distribution systems develop is limited. In this study I examined the growth and change of the Australian music value chain. This includes the development of digital distribution systems and the effect that peer‐to‐peer technology has on system development, specifically the disintermediation between consumers and artists to the detriment of the multinational value chains.
107p runthenight07 01-03-2023 4 3 Download
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Climate change is expected to have a negative impact on food availability. While most efforts have been directed to reducing greenhouse gas emissions, complementary strategies are necessary to control the detrimental effects of climate change on farm animal performance.
10p vihagrid 30-01-2023 5 3 Download
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Upon the commencement of the phase-three decommissioning of Fukushima Daiichi Nuclear Power Station (FDNPS), strategy construction is a necessary step for effective radioactive waste management as well as safe project implementation. In this study, we evaluate safety and environmental detriment (SED) score of radioactive materials in the expected major stages of the project for the strategy construction.
8p vironald 15-12-2022 13 3 Download
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Continued part 1, part 2 of ebook "Selection methods in plant breeding (2nd edition)" provide readers with content about: applications of quantitative genetic theory in plant breeding; selection for several traits; genotype × environment interaction; selection with regard to a trait with quantitative variation; reduction of the detrimental effect of allocompetition on the efficiency of selection; optimizing the evaluation of candidates by means of plots; causes of the low efficiency of selection; the optimum generation to start selection for yield of a self-fertilizing crop;...
237p hanlinhchi 11-11-2022 10 3 Download
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Caregivers health is often at risk due to the detrimental effects of caregiver burden. It is therefore vital to identify strategies and resources, which ensure the safeguarding of caregivers’ health, whilst also enabling caregivers to continue providing high quality long-term care to care-receivers.
14p viferrari 29-10-2022 5 2 Download
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Prescription opioids are commonly used for postoperative pain relief in older adults, but have the potential for misuse. Both opioid side effects and uncontrolled pain have detrimental impacts.
10p viisaacnewton 25-04-2022 9 5 Download
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Hypocalcemia has detrimental effects on health and performance of dairy cows. As hypocalcemic cows show reduced feed intake, we hypothesized that cows with reduced combined rumination and eating time (CRET) may benefit from Ca supplementation.
15p vidarwin 23-02-2022 13 1 Download
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This study results demonstrated that boosted Fe plaque formation can minimize detrimental effects of Cd on rice shoot growth to some extent, but the root tissues are the main barrier to Cd accumulation and movements in the interior of the rice plants.
10p thebadguys 15-01-2022 5 0 Download
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Retrotransposons are genetic elements inducing mutations in all domains of life. Despite their detrimental effect, retrotransposons can become temporarily active during epigenetic reprogramming and cellular stress response, which may accelerate host genome evolution.
19p viarchimedes 26-01-2022 14 0 Download
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ation. However, their residues persisted for more than 30 days with variable half-lives ranged from 2.6 to 30 days. The toxicological study revealed that metabolites C, E and F were highly pernicious to soil enzymes sucrase, catalase, urease and dehydrogenase. PYR do not posed any detrimental effects in adult honeybees. Considering the persistence behavior and toxicological consequences of metabolites, further investigations are needed for preventing their harmful effect on non-target organisms and associated environment.
14p thebadguys 15-01-2022 11 0 Download
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The amending soils with 2% BC or AC changed the biokinetics of VPH degradation by rendering VPHs less bioavailable, but did not appear to have any detrimental effects on VPH degradation and may serve as a sustainable, cost-effective approach for enhancing the natural attenuation of VPHs in soil on the long term.
10p thebadguys 15-01-2022 7 0 Download