Developmental shift
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Our results reveal that distinct functional promoter classes and overlapping promoter codes are present in protochordates like in vertebrates, but show extraordinary lineage-specific innovations. Furthermore, we uncover a genome-wide, developmental stage-specific shift in the mode of TSS selection. Our results provide a rich resource for the study of promoter structure and evolution in Metazoa.
12p vibeauty 23-10-2021 13 0 Download
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High-resolution transcription start site (TSS) mapping in D. melanogaster embryos and cell lines has revealed a rich and detailed landscape of both cis- and trans-regulatory elements and factors. However, TSS profiling has not been investigated in an orthogonal in vivo setting. Here, we present a comprehensive dataset that links TSS dynamics with nucleosome occupancy and gene expression in the wandering third instar larva, a developmental stage characterized by large-scale shifts in transcriptional programs in preparation for metamorphosis.
20p vibeauty 23-10-2021 12 0 Download
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Differential gene expression can be translated into differing phenotypic traits. Especially during embryogenesis, specific gene expression networks regulate the development of different body structures. Cichlid fishes, with their impressive phenotypic diversity and propensity to radiate, are an emerging model system in the genomics era.
15p vigiselle2711 30-08-2021 7 1 Download
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Cotton fibers provide a powerful model for studying cell differentiation and elongation. Each cotton fiber is a singular and elongated cell derived from epidermal-layer cells of a cotton seed. Efforts to understand this dramatic developmental shift have been impeded by the difficulty of separation between fiber and epidermal cells.
16p vilichoo2711 23-06-2021 12 1 Download
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There is a growing global acknowledgement that improving child survival rates is no longer sufficient. Emphasis is shifting to the improvement of health and developmental trajectories in early childhood.
9p videshiki2711 19-02-2020 13 1 Download
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The work with this volume has been carried out at the Center for Developmental Research, Orebro University. It has been supported by grants to Professor H^an Stattin from the Swedish Council for Planning and Coordination of Research, and Axel and Margareta Ax:son Johnsons Foundation, and grants to Professor Margaret Kerr from The Swedish Research Council.
196p banhkem0908 24-11-2012 34 4 Download
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The following chapters discuss architects who have honed digital-fabrication techniques on pecific projects. Each discussion is accompanied by a detailed breakdown of the fabrication technique, providing insight into the recent projects featured in ach chapter. These are projects that concentrate on he fertile realm of one-to-one-scale experimentation, which demands reciprocity between design and mpirical innovation. The final outcomes hinge on he ability to reconcile the developmental shifts in material and working method.
6p quynho77 13-11-2012 46 0 Download