Diabetes identification
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In this continuity, the potentiality of D. citrea essential oil was subjected to screening research. The extract yield was obtained experimentally and its chemical characterization was acquired by gas chromatography-mass spectrometry (GC-MS). The determined data was subjected as the input for computational implementations, including density functional theory calculation, molecular docking simulation, and biopharma-potential predicting analyses.
20p dianmotminh02 03-05-2024 1 1 Download
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Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D.
14p vioraclene 31-03-2024 3 2 Download
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Identification of causal genes for polygenic human diseases has been extremely challenging, and our understanding of how physiological and pharmacological stimuli modulate genetic risk at disease-associated loci is limited.
16p viellison 28-03-2024 7 2 Download
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Diabetic mastopathy is a rare breast condition that occurs in women with poorly controlled diabetes and is characterized by hardening of the breast tissue. The purpose of this case report is to provide an overview of the clinical characteristics and therapeutic principles of this rare disease to support front-line physicians in their crucial activity of case identification.
4p vitiki 30-01-2024 2 2 Download
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We assessed the sensitivity and specificity of 8 electronic health record (EHR)-based phenotypes for diabetes mellitus against gold-standard American Diabetes Association (ADA) diagnostic criteria via chart review by clinical experts.
8p visteverogers 24-06-2023 5 2 Download
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Maturity-onset diabetes of the young comprises a large group of autosomal inherited gene mutations. Maturity-onset diabetes of the young subtype 5 is caused by mutations in the HNF1B gene. This gene is expressed in the early phase of embryonic development in the pancreas, kidneys, liver, and genital tract; therefore, kidney or urinary tract malformations are associated with diabetes mellitus.
6p vidoctorstrange 06-05-2023 4 2 Download
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In this regard, pathway-based analyses of GWAS became popular to discover novel multigenic functional associations. Still, to reveal the unaccounted 85 to 90% of T2D variation, which lies hidden in GWAS datasets, new post-GWAS strategies need to be developed. In this respect, here we reanalyze three metaanalysis data of GWAS in T2D, using the methodology that we have developed to identify disease-associated pathways by combining nominally significant evidence of genetic association with the known biochemical pathways.
33p lyhuyenthu 31-01-2023 9 2 Download
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Integration of high throughput DNA genotyping and RNA-sequencing data allows for the identification of genomic regions that control gene expression, known as expression quantitative trait loci (eQTL), on a whole genome scale. Intramuscular fat (IMF) content and carcass composition play important roles in metabolic and physiological processes in mammals because they influence insulin sensitivity and consequently prevalence of metabolic diseases such as obesity and type 2 diabetes.
20p vibeauty 23-10-2021 3 0 Download
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Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta-cell function and may contribute to development of type 2 diabetes mellitus (T2DM). Whereas mechanisms of impaired glucosestimulated insulin secretion (GSIS) in FFA-treated beta-cells have been intensively studied, biological events preceding the secretory failure, when GSIS is accentuated, are poorly investigated.
11p vitzuyu2711 29-09-2021 13 1 Download
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Biological networks describes the mechanisms which govern cellular functions. Temporal networks show how these networks evolve over time. Studying the temporal progression of network topologies is of utmost importance since it uncovers how a network evolves and how it resists to external stimuli and internal variations.
16p visilicon2711 20-08-2021 7 1 Download
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Malonylation is a recently discovered post-translational modification that is associated with a variety of diseases such as Type 2 Diabetes Mellitus and different types of cancers. Compared with experimental identification of malonylation sites, computational method is a time-effective process with comparatively low costs.
10p vijeeni2711 30-06-2021 7 1 Download
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Effective management of patients with diabetic foot infection is a crucial concern. A delay in prescribing appropriate antimicrobial agent can lead to amputation or life threatening complications. Thus, this electronic nose (e-nose) technique will provide a diagnostic tool that will allow for rapid and accurate identification of a pathogen.
12p vikentucky2711 24-11-2020 13 2 Download
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Diabetic foot ulcer is one of the dreaded complications of uncontrolled diabetic mellitus, leading to consequences like gangrene and amputation of foot. This study was conducted as an endeavor to scrutinise the major genera of bacteria which were in association with the infected diabetic foot ulcers and their antibiotic sensitivity pattern. This prospective analytical study included 100 samples from diabetic foot ulcer patients. Isolation and identification of organism were done based on standard laboratory technique.
7p chauchaungayxua6 26-06-2020 14 1 Download
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Yeasts of the genus Candida have high genetic variability and are the most common opportunistic pathogenic, which isolated from clinical samples that cause many problems to human, frequently isolated from patient which had diabetes mellitus. The aims of study were Detection and isolation and identification of Candida spp. in Diyala province by routine laboratory procedures.
10p gaocaolon5 14-06-2020 10 1 Download
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Diabetes mellitus is a major contributor to morbidity and mortality worldwide. Identification of patient requests, needs and judgment on health care received is the starting point of patients centered approach; therefore patient satisfaction is considered as important measure to evaluate the quality of health services and can predict both compliance and utilization that associated with the continuity of care. 1. Assess type 2 diabetic patients' satisfaction with the provided care at Tanta University Hospitals.
11p nguathienthan5 04-06-2020 10 0 Download
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Klebsiella pneumoniae is a common organism causing bronchopneumonia and is a known pathogen in non-healing diabetic foot infections. KPC strains of Klebsiella pneumonia from Pus and Sputum samples were isolated in Thanjavur Medical College from March to April 2018 which show resistance to beta lactam antibiotics, beta lactamase inhibitors and Carbapenems and confirmed the responsible blaKPC gene by PCR. The study signifies the importance of rational usage of antibiotics.
5p chauchaungayxua5 08-05-2020 8 1 Download
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In silico identification of inhibitors from Salacia reticulate plant against diabetic target protein
Salacia species for its antdiabetic property especially of root, stem and leaf extract. Plant produces several phytochemicals responsible for antidiabetic activity. Four proteins were selected based on literature survey and retrieved from protein data bank. The 18 chemicals were converted into 3 D structure and docked with diabetic protein. Benzeneacetonitrile, .Alpha.-(.Beta.-D-Glucopyranosyloxy)- ,(R)- is a chemical expressed in salacia which showed good antidiabetic property among 18 other chemicals.
8p trinhthamhodang4 22-03-2020 17 1 Download
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Diabetic foot infections (DFIs) is a chronic form of diabetes mellitus (DM) associated with a high economic and social problem worldwide. Approximately 60% of these amputations is preceded by the presence of infected ulcers. Recently, Enterococci, mainly Entrococcus feacalis (E. faecalis), is considered one of the most frequent microorganisms isolated from hospital associated infections in in many parts of the world.
19p trinhthamhodang4 22-03-2020 12 1 Download
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This study shows that the isolation of non-albicans Candida have clinical implications due to their reduced susceptibility to various antifungals, thus highlighting the importance of isolation, species identification and antifungal susceptibility testing prior to initiation of therapy for proper selection of antifungal agent. The judicious use of antifungal agents is very important for the prevention of emergence and spread of drug resistant Candida species.
7p cothumenhmong1 08-12-2019 9 0 Download
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Candida species is the only fungal pathogen that causes variety of afflictions that ranges from superficial mucosal infections to life-threatening disseminated mycoses. Oral candidiasis is a common fungal infection caused by an overgrowth or infection due to Candida spp. Candida albicans is considered as the primary etiology of various clinical types of candidiasis including oral lesions. However, in recent years research studies have highlighted the greater recognition of non-albicans Candida (NAC) spp.
6p nguaconbaynhay1 04-12-2019 17 1 Download